Telephysiotherapy has emerged as a vital solution for delivering remote healthcare, particularly in response to global challenges such as the COVID-19 pandemic. This study seeks to enhance telephysiotherapy by developing a system capable of accurately classifying physiotherapeutic exercises using PoseNet, a state-of-the-art pose estimation model. A dataset was collected from 49 participants (35 males, 14 females) performing seven distinct exercises, with twelve anatomical landmarks then extracted using the Google MediaPipe library.
View Article and Find Full Text PDFDriving while drowsy poses significant risks, including reduced cognitive function and the potential for accidents, which can lead to severe consequences such as trauma, economic losses, injuries, or death. The use of artificial intelligence can enable effective detection of driver drowsiness, helping to prevent accidents and enhance driver performance. This research aims to address the crucial need for real-time and accurate drowsiness detection to mitigate the impact of fatigue-related accidents.
View Article and Find Full Text PDFDriving a vehicle is a complex, multidimensional, and potentially risky activity demanding full mobilization and utilization of physiological and cognitive abilities. Drowsiness, often caused by stress, fatigue, and illness declines cognitive capabilities that affect drivers' capability and cause many accidents. Drowsiness-related road accidents are associated with trauma, physical injuries, and fatalities, and often accompany economic loss.
View Article and Find Full Text PDFA novel approach is presented in this study for the classification of lower limb disorders, with a specific emphasis on the knee, hip, and ankle. The research employs gait analysis and the extraction of PoseNet features from video data in order to effectively identify and categorize these disorders. The PoseNet algorithm facilitates the extraction of key body joint movements and positions from videos in a non-invasive and user-friendly manner, thereby offering a comprehensive representation of lower limb movements.
View Article and Find Full Text PDFCricket has a massive global following and is ranked as the second most popular sport globally, with an estimated 2.5 billion fans. Batting requires quick decisions based on ball speed, trajectory, fielder positions, etc.
View Article and Find Full Text PDFChronic obstructive pulmonary disease (COPD) is a severe and chronic ailment that is currently ranked as the third most common cause of mortality across the globe. COPD patients often experience debilitating symptoms such as chronic coughing, shortness of breath, and fatigue. Sadly, the disease frequently goes undiagnosed until it is too late, leaving patients without the care they desperately need.
View Article and Find Full Text PDFMammography is the gold standard technology for breast screening, which has been demonstrated through different randomized controlled trials to reduce breast cancer mortality. However, mammography has limitations and potential harms, such as the use of ionizing radiation. To overcome the ionizing radiation exposure issues, a novel device (i.
View Article and Find Full Text PDFNoisy environments, changes and variations in the volume of speech, and non-face-to-face conversations impair the user experience with hearing aids. Generally, a hearing aid amplifies sounds so that a hearing-impaired person can listen, converse, and actively engage in daily activities. Presently, there are some sophisticated hearing aid algorithms available that operate on numerous frequency bands to not only amplify but also provide tuning and noise filtering to minimize background distractions.
View Article and Find Full Text PDFBackground: Tyrosinemia type 1 (HT1) is a rare metabolic disorder caused by a defect in the tyrosine catabolic pathway. Since HT1 patients are treated with NTBC, outcome improved and life expectancy greatly increased. However extensive neurocognitive and behavioural problems have been described, which might be related to treatment with NTBC, the biochemical changes induced by NTBC, or metabolites accumulating due to the enzymatic defect characterizing the disease.
View Article and Find Full Text PDFMammoWave is a microwave imaging device for breast lesion detection, employing two antennas which rotate azimuthally (horizontally) around the breast. The antennas operate in the 1-9 GHz band and are set in free space, i.e.
View Article and Find Full Text PDFExisting phenylalanine hydroxylase (PAH)-deficient mice strains are useful models of untreated or late-treated human phenylketonuria (PKU), as most contemporary therapies can only be initiated after weaning and the pups have already suffered irreversible consequences of chronic hyperphenylalaninemia (HPA) during early brain development. Therefore, we sought to evaluate whether enzyme substitution therapy with pegvaliase initiated near birth and administered repetitively to C57Bl/6-Pah mice would prevent HPA-related behavioral and cognitive deficits and form a model for early-treated PKU. The main results of three reported experiments are: 1) lifelong weekly pegvaliase treatment prevented the cognitive deficits associated with HPA in contrast to persisting deficits in mice treated with pegvaliase only as adults.
View Article and Find Full Text PDFEmotion recognition gained increasingly prominent attraction from a multitude of fields recently due to their wide use in human-computer interaction interface, therapy, and advanced robotics, etc. Human speech, gestures, facial expressions, and physiological signals can be used to recognize different emotions. Despite the discriminating properties to recognize emotions, the first three methods have been regarded as ineffective as the probability of human's voluntary and involuntary concealing the real emotions can not be ignored.
View Article and Find Full Text PDFRecently, a novel microwave apparatus for breast lesion detection (MammoWave), uniquely able to function in air with 2 antennas rotating in the azimuth plane and operating within the band 1-9 GHz has been developed. Machine learning (ML) has been implemented to understand information from the frequency spectrum collected through MammoWave in response to the stimulus, segregating breasts with and without lesions. The study comprises 61 breasts (from 35 patients), each one with the correspondent output of the radiologist's conclusion (i.
View Article and Find Full Text PDFRegular inspection of railway track health is crucial for maintaining safe and reliable train operations. Factors, such as cracks, ballast issues, rail discontinuity, loose nuts and bolts, burnt wheels, superelevation, and misalignment developed on the rails due to non-maintenance, pre-emptive investigations and delayed detection, pose a grave danger and threats to the safe operation of rail transport. The traditional procedure of manually inspecting the rail track using a railway cart is both inefficient and prone to human error and biases.
View Article and Find Full Text PDFDrowsiness when in command of a vehicle leads to a decline in cognitive performance that affects driver behavior, potentially causing accidents. Drowsiness-related road accidents lead to severe trauma, economic consequences, impact on others, physical injury and/or even death. Real-time and accurate driver drowsiness detection and warnings systems are necessary schemes to reduce tiredness-related driving accident rates.
View Article and Find Full Text PDFPhenylalanine hydroxylase (PAH) deficiency, colloquially known as phenylketonuria (PKU), is among the most common inborn errors of metabolism and in the past decade has become a target for the development of novel therapeutics such as gene therapy. PAH deficient mouse models have been key to new treatment development, but all prior existing models natively express liver PAH polypeptide as inactive or partially active PAH monomers, which complicates the experimental assessment of protein expression following therapeutic gene, mRNA, protein, or cell transfer. The mutant PAH monomers are able to form hetero-tetramers with and inhibit the overall holoenzyme activity of wild type PAH monomers produced from a therapeutic vector.
View Article and Find Full Text PDFIn this paper, we present an investigation of different artefact removal methods for ultra-wideband Microwave Imaging (MWI) to evaluate and quantify current methods in a real environment through measurements using an MWI device. The MWI device measures the scattered signals in a multi-bistatic fashion and employs an imaging procedure based on Huygens principle. A simple two-layered phantom mimicking human head tissue is realised, applying a cylindrically shaped inclusion to emulate brain haemorrhage.
View Article and Find Full Text PDFMol Ther Methods Clin Dev
June 2020
Phenylketonuria (PKU) due to recessively inherited phenylalanine hydroxylase (PAH) deficiency results in hyperphenylalaninemia, which is toxic to the central nervous system. Restriction of dietary phenylalanine intake remains the standard of PKU care and prevents the major neurologic manifestations of the disease, yet shortcomings of dietary therapy remain, including poor adherence to a difficult and unpalatable diet, an increased incidence of neuropsychiatric illness, and imperfect neurocognitive outcomes. Gene therapy for PKU is a promising novel approach to promote lifelong neurological protection while allowing unrestricted dietary phenylalanine intake.
View Article and Find Full Text PDFAnnu Int Conf IEEE Eng Med Biol Soc
July 2019
A more locally cared for and self-managing aging population along with better attention to self health-care, has resulted in increasing need for non-intrusive monitoring. Wearable, wireless physiological sensors, and cameras can pose user privacy, security and discomfort issues which may have a negative impact on consumer confidence and uptake. Thus, for the first time a non-contact, non-intrusive 3D human motion model is proposed for gait disorder identification from impulse radio ultra-wide band (ITERATOR) with the understanding of spherical trigonometry and vector field.
View Article and Find Full Text PDFBreast lesion detection employing state of the art microwave systems provide a safe, non-ionizing technique that can differentiate healthy and non-healthy tissues by exploiting their dielectric properties. In this paper, a microwave apparatus for breast lesion detection is used to accumulate clinical data from subjects undergoing breast examinations at the Department of Diagnostic Imaging, Perugia Hospital, Perugia, Italy. This paper presents the first ever clinical demonstration and comparison of a microwave ultra-wideband (UWB) device augmented by machine learning with subjects who are simultaneously undergoing conventional breast examinations.
View Article and Find Full Text PDFHome monitoring and remote care systems aim to ultimately provide independent living care scenarios through non-intrusive, privacy-protecting means. Their main aim is to provide care through appreciating normal habits, remotely recognizing changes and acting upon those changes either through informing the person themselves, care providers, family members, medical practitioners, or emergency services, depending on need. Care giving can be required at any age, encompassing young to the globally growing aging population.
View Article and Find Full Text PDFUnobtrusive indoor location systems must rely on methods that avoid the deployment of large hardware infrastructures or require information owned by network administrators. Fingerprinting methods can work under these circumstances by comparing the real-time received RSSI values of a smartphone coming from existing Wi-Fi access points with a previous database of stored values with known locations. Under the fingerprinting approach, conventional methods suffer from large indoor scenarios since the number of fingerprints grows with the localization area.
View Article and Find Full Text PDFThe DNA mismatch repair (MMR) machinery in mammals plays critical roles in both mutation avoidance and spermatogenesis. Meiotic analysis of knockout mice of two different MMR genes, Mlh1 and Mlh3, revealed both male and female infertility associated with a defect in meiotic crossing over. In contrast, another MMR gene knockout, Pms2 (Pms2(ko/ko)), which contained a deletion of a portion of the ATPase domain, produced animals that were male sterile but female fertile.
View Article and Find Full Text PDFA large proportion of individuals who live with type-2 diabetes suffer from plantar sensory neuropathy. Regular testing and assessment for the condition is required to avoid ulceration or other damage to patient's feet. Currently accepted practice involves a trained clinician testing a patient's feet manually with a hand-held nylon monofilament probe.
View Article and Find Full Text PDFRadio-over-fiber (RoF) schemes offer the possibility of permitting direct access to native format services for the domestic user. A low power requirement and cost effectiveness are crucial to both the service provider and the end user. Here, we present an ultra-low cost and power RoF scheme using direct modulation of commercially-available 1344 nm and 1547 nm VCSELs by band-group 1 UWB wireless signals (ECMA-368) at near broadcast power levels.
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