Effects of Acylhydrazone Derivatives on Experimental Pulmonary Inflammation by Chemical Sensitization.

Background: Chronic lung diseases are characterized by airway inflammation and remodelling of the lung parenchyma that triggers considerable impairment of respiratory function.

Objective: In this study, two compounds belonging to the N-acylhydrazone class were evaluated, aiming to identify new therapeutic agents for pulmonary inflammatory diseases.

Materials And Methods: The acute toxicity of 2-cyano-N'-(3-ethoxy-4-hydroxybenzylidene)- acetohydrazide (JR-12) and N'-benzylidene-2-cyano-3-phenylacrylohydrazide (JR09-Bz) was evaluated.

Evaluation of anti-inflammatory activity and molecular docking study of new aza-bicyclic isoxazoline acylhydrazone derivatives.

The aim of this study was to investigate the anti-inflammatory effects of two new isoxazoline-acylhydrazone derivatives: '-(4-methoxybenzylidene)-6-(4-nitro-benzoyl)-3,5,6,6-tetrahydro-4-pyrrolo[3,2-]isoxazole-3-carbohydrazide (R-123) and '-(4-chlorobenzylidene)-6-(4-chlorobenzoyl)-3,5,6,6-tetrahydro-4-pyrrolo[3,2-]isoxazole-3-carbohydrazide (R-99). An air pouch induced by carrageenan was used for screening the best dose of R-99 and R-123. Using this mouse model, leukocyte migration and cytokine levels (TNF-α and IL-1β) were determined.

Anti-inflammatory and antinociceptive activities of the leaf methanol extract of Miconia minutiflora (Bonpl.) DC. and characterization of compounds by UPLC-DAD-QTOF-MS/MS.

Some species of the genus Miconia are used in Brazilian folk medicine as analgesic and anti-inflammatory; however, several species of this genus are still poorly studied. Therefore, the aims of this study were to investigate the phytochemistry characterization by UPLC-DAD-QTOF-MS/MS, acute toxicity, anti-inflammatory and antinociceptive properties of Miconia minutiflora (Bonpl.) DC.

[Standardized nutritional intervention in hypoglycemic inpatients].

The ingestion of rapid absorption carbohydrates (RAC) can be useful to increase serum glucose. This sudy aimed to assess the effectiveness and applicability of nutritional intervention in hypoglycemic situations suffered by conscious inpatients in a general hospital who were receiving oral diet. Seventy-six patients were eligible.

Influence of demographic and metabolic variables on forearm blood flow and vascular conductance in individuals without overt heart disease.

Purpose: Vascular reactivity is involved in the regulation of vascular function either in normal conditions or in the pathophysiology of cardiovascular diseases. We tested the hypothesis that vascular reactivity evaluated by forearm blood flow may vary according to demographic and metabolic variables in a cohort of individuals without any evidence of heart disease after clinical examination.

Subjects And Methods: We studied 186 individuals (mean age 41.