Publications by authors named "Sandra C H Lonien"
Article Synopsis
- Chagas disease, caused by a parasite and affecting around 7 million people primarily in Latin America, involves interactions between the parasite and immune cells like monocytes and dendritic cells.
- Research using DC-enriched peripheral human blood mononuclear cell populations showed that selective COX-2 inhibitor celecoxib and adenilate cyclase inhibitor SQ 22,536 significantly reduced parasitic infection, unlike aspirin, which did not inhibit infection or nitric oxide production.
- The study highlights the role of COX-2 and cAMP pathways in the invasion of immune cells by the parasite, suggesting these pathways could be potential targets for developing new treatments for Chagas disease.
Cell invasion by Trypanosoma cruzi and its intracellular replication are essential for progression of the parasite life cycle and development of Chagas disease. Prostaglandin E2 (PGE) and other eicosanoids potently modulate host response and contribute to Chagas disease progression. In this study, we evaluated the effect of aspirin (ASA), a non-selective cyclooxygenase (COX) inhibitor on the T.
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