Antiproliferative activity of thiazole and oxazole derivatives: A systematic review of in vitro and in vivo studies.

Thiazole and oxazole are compounds with a heterocyclic nucleus that have attracted the attention of medicinal chemistry due to the great variety of biological activities that they enable. In recent years, their study has increased, finding a wide range of biological activities, including antifungal, antiparasitic, anti-inflammatory, and anticancer activities. This systematic review provides evidence from the literature on the antiproliferative and antitumor activities of thiazole and oxazole and their derivatives from 2014 to April 2020.

Activation of the Keap1-Nrf2 pathway by specioside and the -butanol extract from the inner bark of (Bertol) DC.

A large number of chemical compounds exert their antioxidant effects by activation of key transcriptional regulatory mechanisms, such as the transcription factor Nrf2. The aim of this study was to evaluate the activation of the Keap1-Nrf2 pathway by both the -butanol extract obtained from the inner bark of (Bertol) DC and specioside isolated from this extract. The antioxidant activity of the extract and specioside isolated from the inner bark of were evaluated using the oxygen radical absorbance capacity (ORAC) and the 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (DPPH) techniques, whereas their effects on the viability of HepG2 cells was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method.

Nrf2-Mediated Antioxidant Activity of the inner bark extracts obtained from (Bertol) DC and (JACQ) G. Nicholson.

Several ethnobotanical and ethnopharmacological studies have shown the therapeutic potential of plants from the genus , which have long been used in traditional medicine in rural areas of South America, for the treatment of several human diseases. This study aimed to evaluate the Nrf2-mediated antioxidant activity of the inner bark extracts obtained from and . The antioxidant activity of extracts obtained from the inner bark of and was evaluated using the Oxygen radical absorbance capacity (ORAC) technique.