Evaluation of an antibiotic intravenous to oral sequential therapy program.

Aim: This study was designed to analyse the drug consumption difference and economic impact of an antibiotic sequential therapy focused on quinolones.

Method: We studied the consumption of quinolones (ofloxacin/levofloxacin and ciprofloxacin) 6 months before and after the implementation of a sequential therapy program in hospitalised patients. It was calculated for each antibiotic, in its oral and intravenous forms, in defined daily dose (DDD/100 stays per day) and economical terms (drug acquisition cost).