Rational design of coumarin derivatives as antituberculosis agents.

Aim: A series of coumarin derivatives was designed as potential antituberculosis agents.

Results: The compounds were screened against active and dormant Mycobacterium tuberculosis (Mtb). Compounds 3k and 3n were found to have the most promising activity against replicating MtbH37Rv exhibiting minimum inhibitory concentration of 4.