Publications by authors named "Sandip Chaudhuri"
Article Synopsis
- A rod-shaped Gram-negative bacterium from the genus has become a significant pathogen for silkworms, showing multi-drug resistance due to excessive antimicrobial use in sericulture.
- These multi-drug resistant strains can pose health risks to humans through direct contact or contaminated silkworm feces.
- Researchers sequenced the genome of a strain isolated from infected silkworms, revealing important genetic information that could help understand antimicrobial resistance and the bacterium's virulence.
Background: A Phase 2, dose-ranging study of bococizumab, a monoclonal anti-proprotein convertase subtilisin/kexin type 9 antibody, was conducted in Japanese subjects to assess its efficacy, safety, and tolerability in this population.
Methods and results: Two different hypercholesterolemic study populations were enrolled concurrently: Japanese subjects with uncontrolled low-density lipoprotein cholesterol (LDL-C) despite atorvastatin treatment (LDL-C ≥100 mg/dL; n=121), and Japanese subjects naive to lipid-lowering agents and with LDL-C ≥130 mg/dL (n=97). Subjects within each study population were randomized to bococizumab 50, 100, or 150 mg, or placebo, q14D for 16 weeks; an open-label ezetimibe 10 mg daily arm was also included for the atorvastatin-treated population.