Seminiferous epithelium damage after short period of busulphan treatment in adult rats and vitamin B efficacy in the recovery of spermatogonial germ cells.

Several different strategies have been adopted in attempt to recover from chemotherapy-damaged spermatogenesis that is often seen in oncologic patients. In this study, we have evaluated the impact of short period of exposure to busulphan on the haemogram and seminiferous epithelium of adult rats, focusing on spermatogonial depletion and Sertoli cell (SC) integrity. We then examined whether vitamin B supplementation improves the haematological parameters and spermatogonia number.