Publications by authors named "Sandhya Sandhya"
Article Synopsis
- - Cancer is a significant global health concern, with breast cancer being the most common type affecting women, leading to the need for effective treatment strategies like surgery, radiation, and chemotherapy.
- - Ongoing research aims to develop new therapies with lower toxicity, including gene therapy, which seeks to correct defective genes involved in cancer.
- - CRISPR/Cas9 has emerged as a powerful gene-editing tool that enhances targeted therapies by addressing drug resistance and improving immunotherapy for breast cancer, due to its precision and cost-effectiveness.
Article Synopsis
- The standard treatment for pancreatic cancer uses strong drugs, but they can make patients sick and the cancer can become resistant to them.
- A study found a new way to test medicines by using tiny versions of tumors grown from actual patient cells, which helps find new treatments and understand how cancer changes.
- Researchers discovered that cancer cells can become resistant not just by changing their genes but also by adapting their behavior, suggesting there are new targets for better treatments.
Hepcidin mediated ferroportin (Fpn) degradation in macrophages is a well adopted strategy to limit iron availability towards invading pathogens. Leishmania donovani (LD), a protozoan parasite, resides within macrophage and competes with host for availing iron. Using in vitro and in vivo model of infection, we reveal that LD decreases Fpn abundance in host macrophages by hepcidin independent mechanism.
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