Publications by authors named "Sandhya Narikuzhy"
Exploring the impact of biological sex on intrinsic connectivity networks in PTSD: A data-driven approach.
Prog Neuropsychopharmacol Biol Psychiatry
October 2024
Introduction: Sex as a biological variable (SABV) may help to account for the differential development and expression of post-traumatic stress disorder (PTSD) symptoms among trauma-exposed males and females. Here, we investigate the impact of SABV on PTSD-related neural alterations in resting-state functional connectivity (rsFC) within three core intrinsic connectivity networks (ICNs): the salience network (SN), central executive network (CEN), and default mode network (DMN).
Methods: Using an independent component analysis (ICA), we compared rsFC of the SN, CEN, and DMN between males and females, with and without PTSD (n = 47 females with PTSD, n = 34 males with PTSD, n = 36 healthy control females, n = 20 healthy control males) via full factorial ANCOVAs.
Article Synopsis
- Alterations in brain networks, particularly the default mode and salience networks, are linked to PTSD symptoms, with the posterior cingulate cortex (PCC) playing a key role in regulating these changes.
- A study involved 14 PTSD patients and 15 healthy controls to measure PCC connectivity during neurofeedback sessions, comparing conditions where participants either regulated or observed PCC activity.
- Findings reveal that, unlike healthy controls, the PTSD group exhibited stronger PCC connectivity with critical brain areas during regulation, suggesting these connections may underlie symptom improvements in PTSD patients.
Background: Systemic oppression, particularly towards sexual minorities, continues to be deeply rooted in the bedrock of many societies globally. Experiences with minority stressors (e.g.
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