Reversal of haloperidol-induced orofacial dyskinesia by Murraya koenigii leaves in experimental animals.

Context: Orofacial dyskinesia (OD) is a late complication of prolonged neuroleptic treatment characterized by involuntary movements of the oral region. Chronic treatment with neuroleptics leads to development of vacuous chewing movements (VCMs). VCMs in rats are widely accepted as an animal model of OD.