Regionally extensive ejecta layer of the Australasian tektite strewn field: the MIS 20/19 large meteorite impact in mainland South-East Asia.

Unlabelled: Aspects of the Quaternary sedimentary geology of South-East Asia have proven problematic in terms of interpretation as to the origins and relationships of the surface sediment layers. The MIS 20 large meteorite impact (., 788 to 785 ka) occurred within mainland South-East Asia, evident from the well-researched 'Australasian Tektite Strewn Field' which extends over at least one tenth of the surface of the Earth.

Hybrid Reconstruction Approach for Polychromatic Computed Tomography in Highly Limited-Data Scenarios.

Conventional strategies aimed at mitigating beam-hardening artifacts in computed tomography (CT) can be categorized into two main approaches: (1) postprocessing following conventional reconstruction and (2) iterative reconstruction incorporating a beam-hardening model. While the former fails in low-dose and/or limited-data cases, the latter substantially increases computational cost. Although deep learning-based methods have been proposed for several cases of limited-data CT, few works in the literature have dealt with beam-hardening artifacts, and none have addressed the problems caused by randomly selected projections and a highly limited span.

Community-centred disaster recovery: A call to change the narrative.

This paper challenges current approaches to undertaking community-centred disaster recovery. Community-centred approaches are widely recognised as 'the gold standard' for effective recovery from disasters. Yet, they are rarely applied well enough in practice.

Ultimate Charge Transport Regimes in Doping-Controlled Graphene Laminates: Phonon-Assisted Processes Revealed by the Linear Magnetoresistance.

Understanding and controlling the electrical properties of solution-processed 2D materials is key to further printed electronics progress. Here, we demonstrate that the thermolysis of the aromatic intercalants utilized in nanosheet exfoliation for graphene laminates allows for high intrinsic mobility and the simultaneous control of doping type (- and -) and concentration over a wide range. We establish that the intraflake mobility is high by observing a linear magnetoresistance of such solution-processed graphene laminates and using it to devolve the interflake tunneling and intralayer magnetotransport.

Use of Mohr diagrams to predict fracturing in rock masses, with applications for predicting sub-surface behavior.

Mohr diagrams are a simple and effective method that can help geoscientists consider, model, and predict the ranges of mechanical properties of rock, stresses, fluid pressures, and the resultant fractures that are likely to occur in the sub-surface. Mohr diagrams can be used to make predictions about how rocks may respond to change, with a transition from a stable state to fracturing occurring if there are changes in (1) the failure envelope, (2) stresses, and/or (3) fluid pressure. This article uses Mohr diagrams to address two questions of significance to the energy transition.

Statistical image reconstruction with beam-hardening compensation for X-ray CT by a calibration step (2DIterBH).

Background: The beam-hardening effect due to the polychromatic nature of the X-ray spectra results in two main artifacts in CT images: cupping in homogeneous areas and dark bands between dense parts in heterogeneous samples. Post-processing methods have been proposed in the literature to compensate for these artifacts, but these methods may introduce additional noise in low-dose acquisitions. Iterative methods are an alternative to compensate noise and beam-hardening artifacts simultaneously.

A bias-free test of human temporal bisection: Evidence against bisection at the arithmetic mean.

The temporal bisection procedure has been used to assess theories of time perception. A problem with the procedure for measuring the perceived midpoint of two durations is that the spacing of probe durations affects the length of the bisection point. Linear spacing results in longer bisection points closer to the arithmetic mean of the durations than logarithmic spacing.

Cost-effectiveness of expanded latent TB infection testing and treatment: Lynn City, Massachusetts, USA.

Between October 2016 and March 2019, Lynn Community Health Center in Massachusetts implemented a targeted latent TB infection testing and treatment (TTT) program, increasing testing from a baseline of 1,200 patients tested to an average of 3,531 patients tested, or 9% of the population per year. We compared pre-implementation TTT, represented by the first two quarters of implementation data, to TTT, represented by 12 quarters of data. Time, diagnostic, and laboratory resources were estimated using micro-costing.

Knockout of NMDARs in CA1 and dentate gyrus fails to impair temporal control of conditioned behavior in mice.

The hippocampus has been implicated in temporal learning. Plasticity within the hippocampus requires NMDA receptor-dependent glutamatergic neurotransmission. We tested the prediction that hippocampal NMDA receptors are required for learning about time by testing mice that lack postembryonal NMDARs in the CA1 and dentate gyrus (DG) hippocampal subfields on three different appetitive temporal learning procedures.

Age-dependent relationships among diet, body condition, and Echinococcus multilocularis infection in urban coyotes.

Urban coyotes (Canis latrans) in North America increasingly exhibit a high prevalence of Echinococcus multilocularis, a cestode of recent and rising public health concern that uses rodents as intermediate hosts and canids as definitive hosts. However, little is known about the factors that drive the high urban prevalence of this parasite. We hypothesized that the diet of urban coyotes may contribute to their higher E.

Coupled Urban Change and Natural Hazard Consequence Model for Community Resilience Planning.

This paper presents a new coupled urban change and hazard consequence model that considers population growth, a changing built environment, natural hazard mitigation planning, and future acute hazards. Urban change is simulated as an agent-based land market with six agent types and six land use types. Agents compete for parcels with successful bids leading to changes in both urban land use-affecting where agents are located-and structural properties of buildings-affecting the building's ability to resist damage to natural hazards.

A critical review of Natural Flood Management application and spatial prioritisation approaches in tropical island catchments.

Tropical island communities face substantial hydrometrological threats, including flood inundation. Flood risk is increasing, driven by climate change but also other factors including urbanisation, land-cover and land-use (LCLU) change, making flood management challenging to address in practice. Protecting, restoring, and emulating the natural functions of catchments to reduce flood risk, also known as Natural Flood Management (NFM), is a promising method for improving flood management.

Consensus on Social Determinants of Health Knowledge Topics and Behavior Learning Goals Across Primary Care Residencies: Results of a Delphi Study.

Purpose: Social determinants of health (SDH) are a substantial contributor to health outcomes and health inequities across populations. The Accreditation Council for Graduate Medical Education has called for the incorporation of SDH into graduate medical education (GME), yet there is no consensus on what SDH knowledge or skills residents in primary care specialties should have on completion of training. The aim of this study was to develop expert consensus on the most important SDH knowledge topics and behavior learning goals for residents in 4 primary care fields.

New Frontiers in Colorectal Cancer Treatment Combining Nanotechnology with Photo- and Radiotherapy.

Colorectal cancer is the third most common cancer worldwide. Despite recent advances in the treatment of this pathology, which include a personalized approach using radio- and chemotherapies in combination with advanced surgical techniques, it is imperative to enhance the performance of these treatments and decrease their detrimental side effects on patients' health. Nanomedicine is likely the pathway towards solving this challenge by enhancing both the therapeutic and diagnostic capabilities.

Development of a Real-Time PCR Assay for the Detection and Identification of Rubus Stunt Phytoplasma in spp.

Rubus stunt, caused by ' Phytoplasma rubi' (Rubus stunt phytoplasma; RSP), is an economically important disease of Rubus. This disease occurs in wild and cultivated spp. in Europe but has not been reported from North America; however, its major leafhopper vector is well established in western Canada and the U.

Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling.

The mono-ADP-ribosyltransferase PARP7 has emerged as a key negative regulator of cytosolic NA-sensors of the innate immune system. We apply a rational design strategy for converting a pan-PARP inhibitor into a potent selective PARP7 inhibitor (KMR-206). Consistent with studies using the structurally distinct PARP7 inhibitor RBN-2397, co-treatment of mouse embryonic fibroblasts with KMR-206 and NA-sensor ligands synergistically induced the expression of the type I interferon, IFN-β.

Quantification of PARP7 Protein Levels and PARP7 Inhibitor Target Engagement in Cells Using a Split Nanoluciferase System.

PARP7 is an enzyme that catalyzes mono-ADP-ribosylation (MARylation), is a critical regulator of type I interferon signaling, and has emerged as an immune-oncology drug candidate. PARP7 is a labile protein that is regulated in a proteasome-dependent manner. Indeed, endogenous PARP7 levels are undetectable by western blot in most cells.

Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors.

Allosteric coupling between the DNA binding site to the NAD-binding pocket drives PARP-1 activation. This allosteric communication occurs in the reverse direction such that NAD mimetics can enhance PARP-1's affinity for DNA, referred to as type I inhibition. The cellular effects of type I inhibition are unknown, largely because of the lack of potent, membrane-permeable type I inhibitors.

The Winchcombe meteorite, a unique and pristine witness from the outer solar system.

Direct links between carbonaceous chondrites and their parent bodies in the solar system are rare. The Winchcombe meteorite is the most accurately recorded carbonaceous chondrite fall. Its pre-atmospheric orbit and cosmic-ray exposure age confirm that it arrived on Earth shortly after ejection from a primitive asteroid.

Reinforcement rate and the balance between excitatory and inhibitory learning: Insights from deletion of the GluA1 AMPA receptor subunit.

Conditioned responding is sensitive to reinforcement rate. This rate-sensitivity is impaired in genetically modified mice that lack the GluA1 subunit of the AMPA receptor. A time-dependent application of the Rescorla-Wagner learning rule can be used to derive an account of rate-sensitivity by reflecting the balance of excitatory and inhibitory associative strength over time.

Multilocus sequence typing of diverse phytoplasmas using hybridization probe-based sequence capture provides high resolution strain differentiation.

Phytoplasmas are insect-vectored, difficult-to-culture bacterial pathogens that infect a wide variety of crop and non-crop plants, and are associated with diseases that can lead to significant yield losses in agricultural production worldwide. Phytoplasmas are currently grouped in the provisional genus ' Phytoplasma', which includes 49 species. Further differentiation of phytoplasmas into ribosomal groups is based on the restriction fragment length polymorphism (RFLP) pattern of the 16S rRNA-encoding operon, with more than 36 ribosomal groups (16Sr) and over 100 subgroups reported.

The use of portable OSL and IRSL measurements of NaCl in low dose assessments following a radiological or nuclear emergency.

During recovery phases following a nuclear or radiological incident analyses of doses received by members of the public and responders are often required. Several methods have been investigated for use at different timescales after the incident, including assessments based on measurements of materials present at the time of the incident. Common salt has previously been shown to have potential for retrospective dosimetry in the mGy dose range using laboratory instrumentation.