Gastrointestinal cancer incidence after lung transplantation in sarcoidosis patients.

Background: The risk of gastrointestinal (GI) cancer after lung transplantation (LTx) in sarcoidosis patients is not well defined. Given the cancer risks linked to sarcoidosis and organ transplantation, this study investigated the incidence of GI malignancies (DNM), comparing LTx recipients with sarcoidosis or idiopathic pulmonary fibrosis (IPF).

Methods: We analyzed data from the United Network for Organ Sharing registry, including adults with sarcoidosis or IPF who underwent LTx between May 2005 and December 2018.

Metal Pneumonitis from "Non-toxic" Decorative Cake Dust Aspiration: A Case Report.

Introduction: Metallic luster dusts are decorative agents for cakes and other confections. While some powders are labeled "non-edible," they are also marketed as "non-toxic." We present a case of a child who developed acute metal pneumonitis after accidental aspiration of metallic luster dust.

Preclinical and Clinical-Scale Magnetic Particle Imaging of Natural Killer Cells: in vitro and ex vivo Demonstration of Cellular Sensitivity, Resolution, and Quantification.

Purpose: Clinical adoption of NK cell immunotherapy is underway for medulloblastoma and osteosarcoma, however there is currently little feedback on cell fate after administration. We propose magnetic particle imaging (MPI) may have applications for the quantitative detection of NK cells.

Procedures: Human-derived NK-92 cells were labeled by co-incubation with iron oxide nanoparticles (VivoTrax™) for 24 h then excess nanoparticles were washed with centrifugation.

Movement Mediates the Relationship Between Socioeconomic Position and Socioemotional Outcomes in Youth.

Background: Youth from lower socioeconomic positions tend to have poorer socioemotional outcomes, be less physically active, have poorer sleep, and engage in more screen time than their peers from higher socioeconomic positions. The objective of this study was to test the hypothesis that movement behaviors (ie, physical activity, sedentary behavior, and sleep) and changes in combinations of movement behaviors over time (movement trajectories) mediate the relationship between socioeconomic position and socioemotional outcomes in youth.

Methods: This study used socioeconomic position data, scores from Strengths and Difficulties Questionnaires, and time-use diaries from 980 females and 1014 males (2% Australian Indigenous) aged 10-14 from the Longitudinal Study of Australian Children from 2014 to 2018.

Effects of elevated CO on the critical oxygen tension (P) and aerobic metabolism of two oxygen minimum zone (OMZ) hypoxia tolerant squat lobster species.

Marine invertebrates living in oxygen minimum zones (OMZ), where low pO and high pCO conditions co-occur, display physiological mechanisms allowing them to deal with these coupled stressors. We measured aerobic metabolic rate (MR) and the critical oxygen tension (P), and calculated the oxygen supply capacity (α) of both the red (Grimothea monodon) and yellow (Grimothea johni) squat lobsters, under two pCO scenarios (~414 and 1400 μatm). We also measured haemolymph pH, haemocyanin oxygen binding affinity (p), and haemolymph lactate content in both species under normoxia, low pCO hypoxia and high pCO hypoxia.

Structural basis of archaeal FttA-dependent transcription termination.

The ribonuclease FttA (also known as aCPSF and aCPSF1) mediates factor-dependent transcription termination in archaea. Here we report the structure of a Thermococcus kodakarensis transcription pre-termination complex comprising FttA, Spt4, Spt5 and a transcription elongation complex (TEC). The structure shows that FttA interacts with the TEC in a manner that enables RNA to proceed directly from the TEC RNA-exit channel to the FttA catalytic centre and that enables endonucleolytic cleavage of RNA by FttA, followed by 5'→3' exonucleolytic cleavage of RNA by FttA and concomitant 5'→3' translocation of FttA on RNA, to apply mechanical force to the TEC and trigger termination.

Impacts of ash-induced environmental alkalinization on fish physiology, and their implications to wildfire-scarred watersheds.

Changes in land use, a warming climate and increased drought have amplified wildfire frequency and magnitude globally. Subsequent rainfall in wildfire-scarred watersheds washes ash into aquatic systems, increasing water pH and exposing organisms to environmental alkalinization. In this study, 15 or 20 °C-acclimated Chinook salmon (Oncorhynchus tshawytscha) yearlings were exposed to an environmentally-relevant ash concentration (0.

Complications after Oncoplastic Breast Reduction and Impact on Time to Adjuvant Therapy.

Background: Although lumpectomy with oncoplastic breast reduction (OBR) improves cosmetic results and ameliorates symptomatic macromastia, associated complications may delay adjuvant therapy.

Methods: This was a single-institution, retrospective study of OBRs (2015-2021). A major complication was defined as need for IV antibiotics, and/or operation under general anesthesia.

European beech spring phenological phase prediction with UAV-derived multispectral indices and machine learning regression.

Acquiring phenological event data is crucial for studying the impacts of climate change on forest dynamics and assessing the risks associated with the early onset of young leaves. Large-scale mapping of forest phenological timing using Earth observation (EO) data could enhance our understanding of these processes through an added spatial component. However, translating traditional ground-based phenological observations into reliable ground truthing for training and validating EO mapping applications remains challenging.

Complete exhaustion of dissolved nutrients in a large lowland river.

Riverine phytoplankton takes up phosphate, dissolved silicate, and nitrate. We investigated which nutrients are depleted during a Lagrangian sampling in the free-flowing part of the River Elbe in 2023. As part of this study, we tested the hypotheses that nutrient depletion might be caused by (1) above-average phytoplankton biomass or by (2) decreased nutrient load of the river during previous years.

Explanation for symptoms and biographical repair in a clinic for persistent physical symptoms.

Introduction: Biographical disruption describes the process by which illness impacts not just on a person's body and their participation in activities, but also on their sense of self. Biographical disruption is often followed by a process of biographical repair in which identity is reconstructed and a new normality is restored. People with persistent physical symptoms (sometimes referred to as medically unexplained symptoms) experience biographical disruption.

Liver disease as new work in the context of protocolised primary care - do GPs have a role? A qualitative interview study.

Background: Liver disease is common, but not part of routine chronic disease management in primary care.

Aim: The aim of this study was to explore the challenges of implementing pathways of care for liver disease within existing highly protocolised structures in primary care.

Method: Semi-structured interviews with 20 health professionals working in primary care.

Effectiveness of a symptom-clinic intervention delivered by general practitioners with an extended role for people with multiple and persistent physical symptoms in England: the Multiple Symptoms Study 3 pragmatic, multicentre, parallel-group, individually randomised controlled trial.

Background: People with multiple and persistent physical symptoms have impaired quality of life and poor experiences of health care. We aimed to evaluate the effectiveness of a community-based symptom-clinic intervention in people with multiple and persistent physical symptoms, hypothesising that this symptoms clinic plus usual care would be superior to usual care only.

Methods: The Multiple Symptoms Study 3 was a pragmatic, multicentre, parallel-group, individually randomised controlled trial conducted in 108 general practices in the UK National Health Service in four regions of England between Dec 6, 2018, and June 30, 2023.

Reduced Fascicle Area Demonstrated in Ilioinguinal Nerves Resected from Primary Inguinal Herniorrhaphy Patients as Evidence of Compression Neuropathy.

Methods: 30 male patients with primary inguinal hernias undergoing primary inguinal herniorrhaphy were prospectively recruited for ilioinguinal nerve resection and evaluation. Three samples of the resected ilioinguinal nerve (proximal, canal, and distal) were evaluated using Masson's trichrome stain to measure fascicle and total nerve cross-sectional area and detect changes in collagen.

Results: The fascicle cross-sectional area in the canal segment was significantly decreased compared to the proximal control with a large effect size observed ( = 0.

Dissolved trace elements and nutrients in the North Sea-a current baseline.

Primary production is an important driver of marine carbon storage. Besides the major nutrient elements nitrogen, phosphorus, and silicon, primary production also depends on the availability of nutrient-type metals (e.g.

Correctional staff knowledge, attitudes and behaviors toward incarcerated trans people: A scoping review of an emerging literature.

Trans people are incarcerated at disproportionately high rates relative to cisgender people and are at increased risk of negative experiences while incarcerated, including poor mental health, violence, sexual abuse, dismissal of self-identity, including poor access to healthcare. This scoping review sought to identify what is known about the knowledge, attitudes, and behaviors of correctional staff toward incarcerated trans people within the adult and juvenile justice systems. This scoping review was conducted in accordance with the five-stage iterative process developed by Arksey and O'Malley (2005), utilizing the PRISMA guidelines and checklist for scoping reviews and included an appraisal of included papers.