Preparation of cyanoacrylate derivatives and comparison of dual action cyanoacrylate formulations.

The use of cyanoacrylate followed by fluorescent reagents is well known in the field of fingermark visualisation. Treatment with fluorescent reagents that stain the cyanoacrylate deposits will not only enhance the visibility of fingermarks previously thought unusable, but also reveal previously unseen marks. Downside of this approach is the exposure of the evidential material to large amounts of solvent, such as water, methanol and ethanol, thereby potentially destroying other forensic traces.

Synthesis of 4-aminoquinazolines by palladium-catalyzed intramolecular imidoylation of N-(2-bromoaryl)amidines.

Compared with the widespread use of carbonylative Pd-catalyzed cross-coupling reactions, similar reactions involving isocyanide insertion are almost virgin territory. We investigated the intramolecular imidoylative cross-coupling of N-(2-bromoaryl)amidines, leading to 4-aminoquinazolines. After thorough optimization of the reaction with respect to palladium source and loading, ligand, base, temperature, and solvent, a small library of 4-aminoquinazolines was prepared to determine the scope of this method.