Post-intervention control in HIV immunotherapy trials.

Purpose Of Review: While post-treatment control following interruption of standard-of-care antiretroviral therapy (ART) is well described, post-intervention control following immunotherapy in HIV cure-related clinical trials is less well understood. We provide an overview of recent studies that have identified post-intervention controllers and review the mechanisms that may drive this biologically important phenotype.

Recent Findings: Post-intervention controllers have been identified in recent immunotherapy trials testing broadly neutralizing antibodies, immune modulators, modified T cells, checkpoint inhibitors, and gene therapy administered individually or in combination.

Shame on me for needing you: A multistudy examination of links between receiving interpersonal emotion regulation and experiencing shame.

Recent theory and research have drawn attention to interpersonal dimensions of emotion regulation. Yet, few empirical investigations of the outcomes of interpersonal emotion regulation have been conducted. We propose that one negative affective outcome of received interpersonal emotion regulation of conceptual and practical interest is shame.

Deciphering the immunopeptidome in vivo reveals new tumour antigens.

Immunosurveillance of cancer requires the presentation of peptide antigens on major histocompatibility complex class I (MHC-I) molecules. Current approaches to profiling of MHC-I-associated peptides, collectively known as the immunopeptidome, are limited to in vitro investigation or bulk tumour lysates, which limits our understanding of cancer-specific patterns of antigen presentation in vivo. To overcome these limitations, we engineered an inducible affinity tag into the mouse MHC-I gene (H2-K1) and targeted this allele to the KrasTrp53 mouse model (KP/KStrep).

Family history of psychosis in youth at clinical high risk: A replication study.

Having a first-degree relative with a psychotic disorder increases an individual's risk for developing psychosis to 10% compared to 1% in the general population. The impact of being at family high-risk for psychosis (FHR) has been examined in samples of youth who are at clinical high-risk for psychosis (CHR). The second North American Prodrome Longitudinal Study (NAPLS-2) identified very few clinical differences between CHR individuals with and without FHR.

Development of a brief online intervention to address aggression in the context of emotion-related impulsivity: Evidence from a wait-list controlled trial.

Trait-like tendencies to respond impulsively to emotion, labelled emotion-related impulsivity, are robustly related to aggression. We developed and tested an online intervention to address emotion-related impulsivity and aggression. The 6-session intervention focused on behavioral techniques shown to decrease arousal and aggression, supplemented with implementation intentions and smartphone prompts to facilitate skills transfer into daily life.

A brief online intervention to address aggression in the context of emotion-related impulsivity for those treated for bipolar disorder: Feasibility, acceptability and pilot outcome data.

Although aggression is related to manic symptoms among those with bipolar disorder, new work suggests that some continue to experience elevations of aggression after remission. This aggression post-remission appears related to a more general tendency to respond impulsively to states of emotion, labelled emotion-related impulsivity. We recently developed the first intervention designed to address aggression in the context of emotion-related impulsivity.

Maladaptive behavior and affect regulation: A functionalist perspective.

Clinical science has benefited tremendously from taking seriously the proposition that putatively maladaptive behaviors serve psychological functions, prominently among these affect regulation (AR). These functionalist accounts have not only advanced basic clinical science, but also formed the bedrock for the development of effective treatments. Drawing heavily on reinforcement learning theory, we aim to elucidate functional relationships between maladaptive behavior and AR.

Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation.

Purpose: Despite the accumulation of extensive genomic alterations, many cancers fail to be recognized as "foreign" and escape destruction by the host immune system. Immunotherapies designed to address this problem by directly stimulating immune effector cells have led to some remarkable clinical outcomes, but unfortunately, most cancers fail to respond, prompting the need to identify additional immunomodulatory treatment options. We elucidated the effect of a novel treatment paradigm using sustained, low-dose HSP90 inhibition and in syngeneic mouse models using genetic and pharmacologic tools.

Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.

Lung cancer is closely associated with chronic inflammation, but the causes of inflammation and the specific immune mediators have not been fully elucidated. The lung is a mucosal tissue colonized by a diverse bacterial community, and pulmonary infections commonly present in lung cancer patients are linked to clinical outcomes. Here, we provide evidence that local microbiota provoke inflammation associated with lung adenocarcinoma by activating lung-resident γδ T cells.

Notch3 is involved in adipogenesis of human adipose-derived stromal/stem cells.

Human adipose-derived stromal/stem cells (hASCs) have tremendous therapeutic potential and the ability to offer insight into human development and disease. Here we subject human ASCs to siRNA-mediated knockdown of Notch3 cultured under both self-renewing and adipogenic differentiation conditions. Self-renewal was monitored by assessing viability and proliferation rates through staining and alamarBlue assays, respectively.

Versatile endless optical polarization controller/tracker/demultiplexer.

Following an initial discussion of control error signal generation, we present new developments and applications of automatic endless optical polarization control based on a commercial electrooptic LiNbO(3) polarization transformer: (i) Fast tracking and subsequent demultiplexing of DPSK/DQPSK/QAM polarization channels was hitherto limited to a fairly fixed optical input power. With APD photoreceivers used for residual interference detection, we demonstrate here an optical level tolerance of at least 7 dB, compared to only 3 dB for PIN photoreceivers. DPSK channel polarizations are tracked at up to 40 krad/s and higher speed on the Poincaré sphere.

The robustness of subcarrier-index modulation in 16-QAM CO-OFDM system with 1024-point FFT.

We present in numerical simulations the robustness of subcarrier index modulation (SIM) OFDM to combat laser phase noise. The ability of using DFB lasers with SIM-OFDM in 16-QAM CO-OFDM system with 1024-point FFT has been verified. Although SIM-OFDM has lower spectral efficiency compared to the conventional CO-OFDM system, it is a good candidate for 16-QAM CO-OFDM system with 1024-point FFT which uses a DFB laser of 1 MHz linewidth.

Optical time-of-flight measurement based on data transmission in a ring oscillator.

We introduce a novel optical propagation delay measurement scheme for distance estimation. It is based on a ring oscillator in which the oscillation signal is replaced by the clock information contained in optical data. A clock-and-data recovery can recover the oscillation signal at the receive end.

High-speed endless optical polarization stabilization using calibrated waveplates and field-programmable gate array-based digital controller.

A truly endless polarization stabilization experiment with a tracking speed of 15 krad/s is presented. The high-speed polarization tracking is realized by using calibrated lithium niobate linear retardation waveplates as the polarization transformers combined with a very fast digital controller running on a field-programmable gate array (FPGA).

PMD tolerance of polarization division multiplex transmission using return-to-zero coding.

Polarization division multiplex (PolDM) doubles the data rate in existing trunk lines without need for additional optical bandwidth. In the presence of dispersion compensation, polarization mode dispersion (PMD) limits the achievable transmission length. PMD tolerance of standard binary intensity modulation or non-return-to-zero coding has already been published.