Publications by authors named "Sandeep Shrivastava"
Windswept Deformity: A Rare Skeletal Manifestation in an Adolescent with Primary Hyperparathyroidism.
J ASEAN Fed Endocr Soc
December 2024
Article Synopsis
- Primary hyperparathyroidism (PHPT) in adolescents is uncommon and typically leads to more severe symptoms than in adults, with skeletal issues being rare and mostly documented in case studies.
- A unique case is reported of a 19-year-old male with a windswept deformity, characterized by the bending of his legs at the knee, who was diagnosed with PHPT after showing elevated calcium and parathyroid hormone levels.
- After identifying and surgically removing a parathyroid adenoma, the patient's calcium and parathyroid hormone levels returned to normal, and he is now scheduled for corrective surgery once his alkaline phosphatase stabilizes.
Breast cancer is the major cause of cancer-related mortality and frequent malignancies among women worldwide. The TRIM (Tripartite Motif) protein family is a broad and diverse set of proteins that contain a conserved structural motif known as the tripartite motif, which comprises of three different domains, B-box domain, Coiled-coil domain and RBR (Ring-finger, B-box, and coiled-coil) domain. TRIM proteins are involved in regulating cancer growth and metastasis.
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- The review focuses on the critical process of isolating mesenchymal stromal cells (MSCs) from the stromal vascular fraction (SVF) of adipose tissue, emphasizing factors like technique and immediate processing that affect cell functionality.
- It highlights the importance of fine-tuning enzymes during digestion, detailed filtration and centrifugation methods for purifying SVF, and assessing cell viability through techniques like flow cytometry.
- The conclusion calls for standardized protocols in MSC isolation to enhance reproducibility, along with ongoing research and collaboration to ensure patient safety and improve regenerative medicine outcomes.
Introduction: Biologics like growth factors, stem cells, and platelet-rich plasma show potential in stimulating cartilage regrowth and reducing inflammation. By synthesizing preclinical and clinical studies, this study offers insights into how these biologics work and their effectiveness in treating knee osteoarthritis.
Methods And Materials: Twenty-four participants with knee osteoarthritis (Kellgren - Lawrence grade II or III) were enrolled after obtaining consent.
Article Synopsis
- Autologous platelet-rich plasma (PRP) therapy shows promise for improving healing in complex wounds, as evaluated in a decade-long study at a tertiary care center using the new STARS protocol.
- The research involved a two-phase approach, including initial PRP development and the application of STARS, measuring outcomes like wound healing rates and infection control.
- Results indicated high effectiveness, with 97.7% of treated patients achieving infection control and minimal scarring, supporting PRP's integration into modern wound care strategies.
Article Synopsis
- A 38-year-old man experienced left wrist pain, stiffness, and swelling for a year, prompting a visit to the outpatient department.
- MRI and X-rays confirmed a diagnosis of Kienbock's disease, which involves the deterioration of the lunate bone in the wrist.
- Instead of the usual treatments, a new surgical technique involving bone grafting and scaphoid-capitate fusion was used to improve wrist function and reduce pain.
Article Synopsis
- Garre's osteomyelitis is a rare chronic infection mainly affecting the metaphyses of long bones in children and young adults, often linked to dental infections.
- A case study of a 47-year-old woman with proximal tibial Garre's osteomyelitis showcases the diagnostic challenges and emphasizes the need for a multidisciplinary treatment approach.
- The patient's positive outcome underscores the importance of accurate diagnosis and persistent treatment strategies in managing this uncommon orthopedic condition in older adults.
Fracture healing is a dynamic process essential for the restoration of bone integrity and function. However, factors such as patient age, comorbidities, and the severity of the fracture can impede this process, leading to delayed healing or nonunion. Platelet-rich plasma (PRP) has emerged as a promising therapeutic option for enhancing fracture healing.
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- * The study found higher SARS-CoV-2 positivity rates and viral loads in urban samples compared to rural ones, with key factors like population density and humidity affecting the virus's spread.
- * Using a modified SEIPR model, researchers estimated that unreported COVID-19 cases could be significantly higher than confirmed cases, suggesting wastewater surveillance could help authorities manage future outbreaks more effectively.
Total hip arthroplasty (THA) is a widely practiced surgical intervention to alleviate pain and reinstate functionality in individuals afflicted with hip joint pathology. The positioning of the acetabulum assumes paramount significance in determining the efficacy of THA, exerting profound influences on biomechanical dynamics, stability, and the durability of outcomes over time. This comprehensive review meticulously evaluates contemporary methodologies for optimizing acetabular positioning in THA, encompassing advanced technologies such as computer-assisted navigation systems, patient-specific instrumentation, robotic-assisted surgical approaches, image-based planning techniques, and intraoperative fluoroscopy.
View Article and Find Full Text PDFBenign cartilaginous lesions called enchondromas usually appear in the long bones of the limbs. This case report, however, draws attention to an uncommon and unusual appearance of enchondroma near the medial end of clavicle. Because of the unusual location, the diagnostic process was very complex, which presented a challengefor the physicians.
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- - The review examines platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) as potential treatments for knee osteoarthritis, focusing on how they work, their effectiveness, and safety.
- - It notes that both PRP and BMAC show promise in reducing symptoms, improving joint function, and possibly slowing down the progression of osteoarthritis.
- - The authors stress the need for more research on long-term effects, standardized treatment protocols, and cost-effectiveness to better integrate these therapies into clinical practice.
Article Synopsis
- - This case report examines how effective reconstructive surgery is for treating malunited fractures at the ends of the radius and ulna bones
- - It provides an in-depth look at a specific patient's case, including the surgical methods used and the positive effects on recovery
- - The report underscores the need for precision in these surgeries and offers valuable insights that can inform future orthopedic research and practices
Article Synopsis
- This review highlights the role of platelet-rich plasma (PRP) in boosting bone healing, emphasizing its rich content of growth factors and its significance in regenerative medicine.
- It discusses the processes involved in PRP creation, its mechanisms in promoting healing (like growth factor release and improving blood flow), and its clinical applications in orthopedic procedures such as joint replacements and spinal surgeries.
- The review also points out the need for safety guidelines, standardized preparation methods, and the future possibilities for PRP, including its use in children and deeper research into inflammatory bone diseases.
We present a case report of a 66-year-old male patient with a known history of leprosy who presented with pain and swelling in his right foot for the past 1.5 years. Fine needle aspiration cytology (FNAC) revealed non-inflammatory exudate, and (MTB) was identified in the sample by the cartridge-based nucleic acid amplification test (CBNAAT).
View Article and Find Full Text PDFIn this case report, a 29-year-old man underwent surgery to treat a fracture to the left distal end of his radius using closed reduction and K-wire fixation. The patient was advised to follow up in the outpatient department after six weeks for cast and K-wire removal. Still, the patient failed to do so and was doing alternate day dressing of the K-wires.
View Article and Find Full Text PDFThis case report describes the unusual presentation of tuberculosis (TB) affecting the cuboid bone in a 16-year-old male patient. The patient presented with a one-year history of progressive foot pain, a discharging sinus, evening rise of temperature, weight loss, and loss of appetite. Clinical examination revealed soft tissue swelling and the presence of caseous material oozing from the sinus.
View Article and Find Full Text PDFThis comprehensive review explores the applications of platelet-rich plasma (PRP) in the context of compound fracture care, providing a thorough examination of its biological mechanisms, preparation techniques, and clinical implications. The analysis highlights PRP's potential in accelerating bone healing, enhancing soft tissue repair, reducing inflammation and infection risks, and managing pain during fracture recovery. The review underscores the importance of ethical and regulatory considerations in integrating PRP into orthopaedic practice, emphasising informed consent, transparent patient communication, and ongoing monitoring of ethical concerns.
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- Platelet-rich plasma (PRP) is gaining attention for its ability to speed up skin wound healing, highlighting its composition, action mechanisms, and various activation methods.
- *The review discusses PRP’s effectiveness in treating both chronic and acute wounds as well as its roles in cosmetic procedures while addressing safety concerns like infections and adverse reactions.
- *Future prospects for PRP include advancements in technology, combination therapies, and personalized medicine, suggesting it could become a key treatment option in wound healing and regenerative medicine.*
Article Synopsis
- Epigenetic and genetic changes work together in cancer development, with DNA methylation, particularly by the enzyme DNMT1, significantly contributing to tumor growth and metastasis.
- High levels of DNMT1 are found in many cancer types, including breast cancer, where overexpression leads to increased cell migration and invasiveness, but inhibiting DNMT1 can reduce these cancerous behaviors.
- The study reveals that BMP-2 signaling can increase DNMT1 expression, while the cholesterol-lowering drug simvastatin can decrease it, highlighting a connection between cholesterol pathways and DNMT1 regulation in cancer cells.
Article Synopsis
- Cancer remains a leading cause of death, with its molecular mechanisms varying significantly by type and even within the same tumor, particularly concerning pathological mineralization in cancers like breast, prostate, and lung.
- This study investigates the osteoblast-like potential in lung cancer A549 cells by conducting various assays to assess markers and activities related to bone cell formation, revealing that these cells do exhibit such potential.
- The research also shows that metformin can inhibit the BMP-2 induced increase in osteoblast-like characteristics and the epithelial to mesenchymal transition in A549 cells, suggesting a way to prevent calcification in lung cancer tissues.
Indian hospitals (especially government-run public sector hospitals) have a nonexistent antimicrobial stewardship program (AMSP). After successfully initiating AMSPs in tertiary care hospitals of India, the Indian Council of Medical Research envisages implementing AMSP in secondary care hospitals. This study is about the baseline data on antibiotic consumption in secondary care hospitals.
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- The study looked at wastewater in Nagpur, India, to find out what viruses were present during the COVID-19 pandemic.
- Researchers found many types of viruses, including chikungunya and rabies, that had never been seen in wastewater before.
- They discovered that SARS-CoV-2 (the virus that causes COVID-19) was common, especially in rural areas, along with other infections like Hepatitis C.