Publications by authors named "Sandeep S Naik"
Article Synopsis
- The study focuses on creating and analyzing poly(L-lysine)-b-poly(propylene oxide)-b-poly(L-lysine) (KPK) triblock copolymers with a high proportion of lysine, over 75 wt%.
- Unlike PK diblock copolymers, the KPK triblock copolymers show changes in shape based on the pH levels, transitioning between spherical micelles, vesicles, and disk micelles.
- The researchers explain these shape shifts by examining the energy costs of the core P block folding into spherical micelles, which relates to the charge conditions of the K block and its effect on surface curvature.
Article Synopsis
- A series of poly(propylene oxide)-b-poly(L-lysine) (PPO-PK) block copolymers were created using a specific chemical reaction, and their behavior when dissolved in solution was analyzed using various microscopy and spectroscopy techniques.
- The PPO-PK copolymers showed a notable difference in pH behavior compared to previous poly(lysine) studies, which may be linked to changes in the hydrophobic properties of the PPO core.
- The study also explored how the unique properties of these copolymers could lead to self-assembly that responds to both pH and temperature, and assessed their potential for drug delivery through vesicle formation.
Case of the month #139. Central nervous system Langerhans cell histiocytosis.
Can Assoc Radiol J
December 2008