High-Altitude Medicinal Plants as Promising Source of Phytochemical Antioxidants to Combat Lifestyle-Associated Oxidative Stress-Induced Disorders.

Oxidative stress, driven by reactive oxygen, nitrogen, and sulphur species (ROS, RNS, RSS), poses a significant threat to cellular integrity and human health. Generated during mitochondrial respiration, inflammation, UV exposure and pollution, these species damage cells and contribute to pathologies like cardiovascular issues, neurodegeneration, cancer, and metabolic syndromes. Lifestyle factors exert a substantial influence on oxidative stress levels, with mitochondria emerging as pivotal players in ROS generation and cellular equilibrium.

Highly Electrophilic Mononuclear Cationic Aluminium Alkoxide Complexes: Syntheses, Reactivity and Catalytic Applications.

Herein, we report the synthesis of β-diketiminate-supported aluminium complexes bearing terminal alkoxide and mono-thiol functional groups: LAlOMe(Et) (2), LAlOtBu(Et) (3), and LAlSH(Et) (4), (L=[HC{C(Me)N-(2,6-iPr C H )} ]). Complexes 2 and 3 are further used as synthons to generate the fascinating cationic aluminium alkoxide complexes, [LAlOMe(μ-OMe)-Al(Et)L][EtB(C F ) ] (5), [LAlOMe(OEt )][EtB(C F ) ] (6), and [LAlOtBu(OEt )][EtB(C F ) ] (8). These electrophilic cationic species are well characterized by spectroscopic and crystallographic techniques.

A review on efforts for improvement in medicinally important chemical constituents in through biotechnological interventions.

The genus belongs to the family Ranunculaceae, is endowed with more than 350 species on the earth. Medicinally important aconitine type of diterpenoid alkaloids are the characteristic compounds in most of the species. The present review endeavored the major research carried out in the field of genetic resource characterization, pharmacological properties, phytochemistry, major factors influencing quantity, biosynthetic pathways and processing methods for recovery of active ingredients, variety improvement, propagation methods, and important metabolite production through cell/organ culture of various species.

Hydroboration of Imines and Alkynes Catalyzed by Electronically Unsaturated Aluminum Hydride and Methyl Aluminum Cations.

Aluminum hydride cations, [AlH][HB(CF)] () and [AlH][B(CF)] (), and the methyl aluminum cation, [AlMe][B(CF)] () ( = [{(2,6-PrCHN)P(Ph)}N]), due to their electronic and coordinative unsaturation at the Al center, exhibit high Lewis acidity and have been exploited for catalytic hydroboration (using HBpin/HBcat) of a variety of imines and alkynes. These catalysts, under mild reaction conditions, afford excellent yields of the respective products. Thorough mechanistic investigations have been performed using a series of stoichiometric experiments and successful isolation of the key intermediates was accomplished.

Pharmacological and phytochemical potential of Rubus ellipticus: a wild edible with multiple health benefits.

Objectives: Rubus ellipticus (family Rosaceae) is used for its delicious edible fruits in the Himalayan region and other parts of the globe. However, the full potential of the species is yet to be harnessed. The current review focuses on the phytochemical, traditional uses, morphological, molecular and pharmacological potential of R.

Plant Specialised Glycosides (PSGs): their biosynthetic enzymatic machinery, physiological functions and commercial potential.

Plants, the primary producers of our planet, have evolved from simple aquatic life to very complex terrestrial habitat. This habitat transition coincides with evolution of enormous chemical diversity, collectively termed as 'Plant Specialised Metabolisms (PSMs)', to cope the environmental challenges. Plant glycosylation is an important process of metabolic diversification of PSMs to govern their in planta stability, solubility and inter/intra-cellular transport.

Modeling the effect of climate change on the distribution of threatened medicinal orchid Satyrium nepalense D. Don in India.

It is vital to understand the distribution area of a threatened plant species for its better conservation and management planning. Satyrium nepalense (family: Orchidaceae) is a threatened terrestrial orchid species with valuable medicinal and nutritional properties. The survival of S.

Predicting the distributional range shifts of Rhizocarpon geographicum (L.) DC. in Indian Himalayan Region under future climate scenarios.

Himalaya, the highest mountain system in the world and house of important biodiversity hotspot, is sensitive to projected warming by climate change. Rhizocarpon geographicum (map lichen), a crustose lichen, grows in high mountain ranges, is a potential indicator species of climate change. In the present study, MaxEnt species distribution modeling algorithm was used to predict the suitable habitat for R.

Diabetes and plant-derived natural products: From ethnopharmacological approaches to their potential for modern drug discovery and development.

Diabetes is a disease of serious concern faced by the health care industry today. Primary diabetes mellitus and its complications are still costly to manage with modern drugs. Extensive research on the screening of anti-diabetic agents in past decades established natural products as one of the major potential sources of drug discovery.

Cross-transferability of SSR markers developed in Rhododendron species of Himalaya.

Rhododendron is a genus of evergreen woody ornamental plants of northern hemisphere with strong cold resistance, attractive flowers and high altitude adaptation capacity. The genus originated and diversified from Sino-Himalayan region and spread across the world, and has high species diversity in Northeast India. To assess cross-species amplification, we tested 32 microsatellites markers in fifteen taxa of the genus Rhododendron of North-eastern Himalaya, of which fourteen microsatellites were newly developed from Rhododendron simsii, and eighteen microsatellites were previously developed from Rhododendron catawbiense and Rhododendron mucronatum var.

Hydrosilylation of Carbonyls Catalyzed by Hydridoborenium Borate Salts: Lewis Acid Activation and Anion Mediated Pathways.

The electronically unsaturated three-coordinated hydridoborenium cations [BH][HB(CF)] () and [BH][B(CF)] (), supported by a bis(phosphinimino)amide ligand, were found to be excellent catalysts for hydrosilylation of a range of aliphatic and aromatic aldehydes and ketones under mild reaction conditions ( = [{(2,4,6-MeCHN)P(Ph)}N]). The key steps of the catalytic cycle for hydrosilylation of PhCHO were monitored via in situ multinuclear NMR measurements for catalysts and . The combined effect of carbonyl activation via the Lewis acidic hydridoborenium cation and the hydridic nature of the borate counteranion in makes it a more efficient catalyst in comparison to that of carbonyl activation via the predominant Lewis acid activation pathway operating with catalyst .

Development of polymorphic EST-SSR markers and their applicability in genetic diversity evaluation in Rhododendron arboreum.

The genus Rhododendron, known for large impressive flowers is widely distributed throughout the world. Rhododendrons have limited genetic information, despite of comprising high species diversity, morphological overlap and weak genetic barrier. In present study, expressed sequence tag (EST) data from Rhododendron catawbiense Michx (Subgenus Hymenanthes, Section Ponticum) and Rhododendron mucronatum var.

Variability in morphology, phytochemicals, and antioxidants in Polygonatum verticillatum (L.) All. populations under different altitudes and habitat conditions in Western Himalaya, India.

Polygonatum verticillatum (L.) All. is one among eight species of Astavarga group of plants known for its vitality strengthening properties and used in different herbal formulations.

Valeriana jatamansi: An herbaceous plant with multiple medicinal uses.

Valeriana jatamansi Jones (Family: Caprifoliaceae), a high value medicinal plant, was distributed in many countries of Asia. The species possesses important valepotriates and is a good source of flavones or flavone glycosides, lignans, sesquiterpenoids or sesquiterpenoid glycoside, bakkenolide type sesquiterpenoids, phenolic compounds, terpinoids, etc. The use of the species in traditional and modern medicines is well known.

Diversity of bioactive compounds and antioxidant activity in Delicious group of apple in Western Himalaya.

Apple contributes significantly to the livelihood and health of the people living in Himalayan regions. Among others, the Delicious group of apple is known for their health promoting and income generating attributes. However, the systematic investigation on morphological and phytochemical attributes of the apple growing in Indian Himalayan region is poorly known.

Hedychium spicatum: a systematic review on traditional uses, phytochemistry, pharmacology and future prospectus.

Objectives: Hedychium spicatum Buch. Ham. ex D.

Influence of the growth phenophases on the phenolic composition and anti-oxidant properties of Wall. in western Himalaya.

Wall. is one of the important Himalayan medicinal plant used in traditional as well as in modern health care system. The present study aimed to find out the influence of different phenophases on the phenolic compounds and anti-oxidant properties by analysing after every week for over 4 months from shoot bud initiation to the preparation of senescence.

Nutraceutical potential of selected wild edible fruits of the Indian Himalayan region.

Wild edible fruits contribute significantly to the nutritional security of mankind across the globe. However, detailed analyses of health promoting bioactive compounds and antioxidants are lacking, especially in Himalayan wild edible fruits. Bioactive compounds and antioxidant potential of 10 wild edible fruits reveal that Terminalia chebula, Phyllanthus emblica and Myrica esculenta are the richest source of total phenolics; Pyaracantha crenulata, Terminalia chebula and Berberis asiatica for flavonoids; Phyllanthus emblica, Morus alba and Ficus palmata for ascorbic acid, anthocyanins, and Morus alba for β-carotene.

Anti-oxidant and anti-microbial properties of some ethno-therapeutically important medicinal plants of Indian Himalayan Region.

Therapeutic potential of medicinal plants as a source of noble natural anti-oxidants and anti-microbial agents has been well recognised all across the globe. In this study, phenolic compounds, in vitro anti-oxidant activity and anti-microbial properties have been investigated in five Himalayan medicinal plants, (e.g.

Genetic diversity and differentiation in Hedychium spicatum, a valuable medicinal plant of Indian Himalaya.

Hedychium spicatum, a perennial rhizomatous medicinal plant distributed in subtropical and temperate parts, is considered nearly endemic to the Himalayan region.In this study allozyme markers were utilized to assess genetic variations and relationships among 12 distinct populations of this species from the West Himalaya of India. A high level of genetic diversity was found among the populations.

Assessment of Antioxidant Properties in Fruits of Myrica esculenta: A Popular Wild Edible Species in Indian Himalayan Region.

Crude extract of Myrica esculenta fruits, a wild edible species of Indian Himalayan Region, was evaluated for phenolic compounds and antioxidant properties. Results revealed significant variation in total phenolic and flavonoid contents across populations. Among populations, total phenolic content varied between 1.