Publications by authors named "Sandeep Kumar Jain R"
Article Synopsis
- Pancreatic cancer has a very low 5-year survival rate of less than 5%, and the current treatment, gemcitabine, faces challenges due to the development of chemoresistance, especially influenced by nicotine in the tumor microenvironment.
- The study investigates how nicotine contributes to this resistance in pancreatic cancer cells (PANC-1 and MIA PaCa-2) and explores the potential of Embelin, a natural compound, to counteract this resistance by enhancing gemcitabine sensitivity.
- Results showed increased resistance markers in nicotine-treated cells, but Embelin significantly reduced cell viability and caused cell cycle arrests, suggesting its potential role as a chemosensitizer in overcoming nicotine-induced chemoresistance.
A series of new thiophene analogues with acarbonitrile-basedmoiety were designed and synthesized via structural optimization. The conjugates were assessed for their in-vitro cytotoxic activity against a human pancreatic cancer cell line (Mia PaCa-2) and among them compound 5b showed IC value of 13.37 ± 2.
View Article and Find Full Text PDFAlcohol-induced oxidative stress is a key player in the development of liver diseases, and herbal alternatives are important means of ameliorating the hepatotoxic effects. The study aimed to evaluate the hepatoprotective potentiality of Artabotrys odoratissimus, an important medicinal shrub from the family Annonaceae. The phenolic compounds from bark ethanol extract (BEE) were detected using RP-HPLC.
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