Publications by authors named "Sandeep Konduru"
One novel tissue engineering approach to mimic in vivo bone formation is the use of aggregate or micromass cultures. Various qualitative and quantitative techniques, such as histochemical staining, protein assay kits and RT-PCR, have been used previously on cellular aggregate studies to investigate how these intricate arrangements lead to mature bone tissue. However, these techniques struggle to reveal spatial and temporal distribution of proliferation and mineralization simultaneously.
View Article and Find Full Text PDFA facile in vitro model to study rapid mineralization in bone tissues.
Biomed Eng Online
September 2014
Background: Mineralization in bone tissue involves stepwise cell-cell and cell-ECM interaction. Regulation of osteoblast culture microenvironments can tailor osteoblast proliferation and mineralization rate, and the quality and/or quantity of the final calcified tissue. An in vitro model to investigate the influencing factors is highly required.
View Article and Find Full Text PDFArticle Synopsis
- Traditional techniques for trans-femoral amputation often have unsatisfactory results, and myodesis has been recommended to improve surgical outcomes.
- A new myodesis technique developed in Dundee showed promising results for elderly dysvascular patients, with 78.5% of those fitted with prosthetics still using them after a 40-month follow-up.
- This technique led to excellent clinical outcomes, including 100% primary wound healing and a low revision surgery rate, making it particularly beneficial for patients with shorter stumps and poor bone quality.