Publications by authors named "Sandeep Kapur"

The implementation of robotic assisted surgery (RAS) has brought in a change to the perception and roles of theatre staff, as well as the dynamics of the operative environment and team. This study aims to identify and describe current perceptions of theatre staff in the context of RAS. 12 semi-structured interviews were conducted in a tertiary level university hospital, where RAS is utilised in selected elective settings.

View Article and Find Full Text PDF

Background: Vitiligo is a chronic acquired, stigmatizing disease characterized by discoloration of skin and mucous membranes. Patients suffering from this condition suffer from a lack of confidence and psychological stress.

Aim: To assess depression, anxiety, and social anxiety among patients suffering from vitiligo.

View Article and Find Full Text PDF

Background: A positive circumferential resection margin (CRM) after rectal cancer surgery, which can be the result of direct or indirect tumour involvement, has consistently been associated with increased local recurrence and poorer survival. However, little is known of the differential impact of the mode of tumour involvement on outcomes.

Methods: 1460 consecutive patients undergoing rectal cancer resection between 2003 and 2018 were retrospectively assessed.

View Article and Find Full Text PDF
Article Synopsis
  • Previous studies showed that sesame oral immunotherapy (S-OIT) is effective in children over 4 years using high doses, but preschoolers may find tahini unappetizing and tolerate lower doses.
  • This study focused on the safety and effectiveness of a lower dose (200 mg) S-OIT for preschoolers with sesame allergies.
  • Results indicated that this lower maintenance dose is both safe and effective, with a majority of participants successfully tolerating higher amounts of sesame protein after treatment.
View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how patient characteristics like age, initial reactions, and specific IgE levels influence safety outcomes during peanut oral immunotherapy (P-OIT), aimed at improving decision-making between clinicians and families.
  • Data from the Food Allergy Immunotherapy (FAIT) registry were analyzed, revealing that certain factors, including previous reactions and higher IgE levels, are linked to more severe reactions during treatment.
  • Key findings emphasize the importance of individualized risk assessment for patients undergoing P-OIT to ensure safer therapeutic outcomes.
View Article and Find Full Text PDF

Background: Our group previously described preschool peanut oral immunotherapy (OIT) in a real-world, multicenter setting, suggesting that this therapy is safe for most preschoolers.

Objective: To examine the safety and tolerability of tree nut (TN) OIT in preschoolers in the real world.

Methods: As part of a Canada-wide quality improvement project, TN-OIT (cashew/pistachio, walnut/pecan, hazelnut, almond, and macadamia nut) was performed in preschoolers who had (1) a skin prick test wheal diameter greater than or equal to 3 mm or a specific IgE level greater than or equal to 0.

View Article and Find Full Text PDF

Competing and coexisting policies (CACPs) may arise from the incompatibility of incentives, standards, and regulatory models between a local state and a federal government, or between two government jurisdictions across which supply networks operate. Traditional studies of supply chain dynamics typically explore the impact of policy regimens as standalone instruments. This study explores how the interplay between CACP regimens can affect the supply dynamics between producers, customers, and their intermediaries.

View Article and Find Full Text PDF

Background: The evidence to guide the management of asymptomatic radiologically-detected anastomotic leakages (ARAL) following anterior resection (AR) with diverting ileostomy is deficient. This study describes the outcomes of managing ARAL one of the UK teaching hospitals.

Method: The study included all patients diagnosed with ARAL following AR during 8 years period (2012-2020).

View Article and Find Full Text PDF

The result of an extra-levator abdominoperineal excision of the rectum (ELAPE) is a composite three-dimensional defect. This is performed for locally advanced anorectal cancer, and may involve partial excision of the vagina. The aim of reconstruction is to achieve wound healing, restore the pelvic floor and to allow micturition and sexual function.

View Article and Find Full Text PDF
Article Synopsis
  • A study examined the safety and effectiveness of peanut oral immunotherapy (P-OIT) for preschoolers, noting that only a small percentage (0.4%) experienced severe reactions during the treatment period.
  • After one year of P-OIT maintenance, 78.6% of participants showed successful desensitization, indicating a negative follow-up oral food challenge (OFC), while the majority tolerated high doses of peanuts.
  • The findings suggest that P-OIT is an effective option for preschoolers with peanut allergies, as it increases their tolerance and offers a potential alternative to strict peanut avoidance.
View Article and Find Full Text PDF

Purpose: Malignant large bowel obstruction is a surgical emergency that requires urgent decompression. Stents are increasingly being used, though reported outcomes are variable. We describe our multidisciplinary experience in using stents to manage malignant large bowel obstruction.

View Article and Find Full Text PDF
Article Synopsis
  • - In a 2017 trial, preschool peanut oral immunotherapy (P-OIT) was deemed safe, with mostly mild reactions and only 1 moderate case needing epinephrine.
  • - A follow-up study in Canada involved 270 preschool children receiving P-OIT, where 243 reached the maintenance dose over 16 to 22 weeks, and 67.8% experienced some reactions, primarily mild.
  • - The results suggest that while P-OIT is safe for most children, a small percentage (0.4%) may still experience severe reactions, highlighting the need for caution.
View Article and Find Full Text PDF
Atopic dermatitis.

Allergy Asthma Clin Immunol

September 2018

Atopic dermatitis (AD) is a common, chronic skin disorder that can significantly impact the quality of life of affected individuals as well as their families. Although the pathogenesis of the disorder is not completely understood, it appears to result from the complex interplay between defects in skin barrier function, environmental and infectious agents, and immune dysregulation. There are no diagnostic tests for AD; therefore, the diagnosis is based on specific clinical criteria that take into account the patient's history and clinical manifestations.

View Article and Find Full Text PDF

Background: Several ways of performing laparoscopic right hemicolectomy (RHC) have evolved. The vascular pedicle can be divided into extracorporeal (RHC-EC) or intracorporeal (RHC-IC). It is not known whether vessel ligation during RHC-EC is as central as during RHC-IC.

View Article and Find Full Text PDF

The -- were developed to build on previous food allergy guidelines after several key studies demonstrated the benefit of early introduction of allergenic foods. These landmark studies including the Learning Early about Peanut (LEAP), LEAP-On and Enquiring about Tolerance trials created a paradigm shift in food allergy prevention. The "take home" messages of this guideline include that peanut should be introduced early in the first year of life, and for the majority of infants, peanut can be introduced at home.

View Article and Find Full Text PDF

The purpose of this brief communication is to highlight emerging evidence regarding potential benefits of supporting early rather than delayed peanut introduction during the period of complementary food introduction in infants. This document should be considered as interim guidance based on consensus among the following organizations: American Academy of Allergy, Asthma, and Immunology, American Academy of Pediatrics, American College of Allergy, Asthma, and Immunology, Australasian Society of Clinical Immunology and Allergy, Canadian Society of Allergy and Clinical Immunology, European Academy of Allergy and Clinical Immunology, Israel Association of Allergy and Clinical Immunology, Japanese Society for Allergology, Society for Pediatric Dermatology, and World Allergy Organization. More formal guidelines regarding early-life, complementary feeding practices and the risk of allergy development will follow in the next year from the National Institute of Allergy and Infectious Diseases-sponsored Working Group and the European Academy of Allergy and Clinical Immunology.

View Article and Find Full Text PDF

The purpose of this brief communication is to highlight emerging evidence to existing guidelines regarding potential benefits of supporting early, rather than delayed, peanut introduction during the period of complementary food introduction in infants. This document should be considered as interim guidance based on consensus among the following organizations: American Academy of Allergy, Asthma & Immunology, American Academy of Pediatrics, American College of Allergy, Asthma & Immunology, Australasian Society of Clinical Immunology and Allergy, Canadian Society of Allergy and Clinical Immunology, European Academy of Allergy and Clinical Immunology, Israel Association of Allergy and Clinical Immunology, Japanese Society for Allergology, Society for Pediatric Dermatology, and World Allergy Organization. More formal guidelines regarding early-life, complementary feeding practices and the risk of allergy development will follow in the next year from the National Institute of Allergy and Infectious Diseases-sponsored Working Group and the European Academy of Allergy and Clinical Immunology.

View Article and Find Full Text PDF

The purpose of this brief communication is to highlight emerging evidence to existing guidelines regarding potential benefits of supporting early, rather than delayed, peanut introduction during the period of complementary food introduction in infants. This document should be considered as interim guidance based on consensus among the following organizations: American Academy of Allergy, Asthma & Immunology, American Academy of Pediatrics, American College of Allergy, Asthma & Immunology, Australasian Society of Clinical Immunology and Allergy, Canadian Society of Allergy and Clinical Immunology, European Academy of Allergy and Clinical Immunology, Israel Association of Allergy and Clinical Immunology, Japanese Society for Allergology, Society for Pediatric Dermatology, and World Allergy Organization. More formal guidelines regarding early-life, complementary feeding practices and the risk of allergy development will follow in the next year from the National Institute of Allergy and Infectious Diseases-sponsored Working Group and the European Academy of Allergy and Clinical Immunology.

View Article and Find Full Text PDF