Publications by authors named "Sandeep K Mundhra"
Article Synopsis
- Crohn's disease (CD) is linked to an increased risk of cancer, partly due to disease characteristics and immunosuppressive treatment; this study focuses on data from a northern Indian cohort to shed light on CD-related malignancies in Asia.
- A total of 952 participants, with a mean age of 36.9 years and a follow-up period of 34 months, were analyzed, revealing a malignancy occurrence rate of 1.05%, which is 10.45 times higher than the general population.
- By 30 years of diagnosis, the cumulative cancer risk for Indian individuals with CD was found to be 13.4%, covering various types of malignancies including bowel and extraintestinal cancers, but no cases of
Article Synopsis
- A study was conducted to evaluate the effectiveness of intravenous albumin infusions in patients with acute severe ulcerative colitis (ASUC) who were not responding to standard steroids.
- The trial involved 61 patients, who were divided into two groups: one receiving albumin with standard care and exclusive enteral nutrition, and the other receiving only standard care and nutrition.
- Results showed no significant difference in steroid response, need for colectomy, or adverse events between the two groups, indicating that albumin infusion did not provide additional benefits for ASUC patients.
Background: Perianal fistulas (PF) affect one-third patients with Crohn's disease (CD) with limited therapeutic options. There is dearth of literature on safety and efficacy of bone marrow-derived mesenchymal stromal cells (BMSCs) in this population.
Methods: An open-label, phase I/II, single-arm study was conducted involving local administration of human allogeneic bone marrow-derived mesenchymal stromal cells in perianal fistula of patients with Crohn's disease refractory to standard therapies.
Background & Aims: Coconut water (CW) is anti-inflammatory, can manipulate the gut microbiome, and is a rich source of potassium. Gut microbiome modulation improves outcomes in ulcerative colitis (UC), and potassium possesses in vitro anti-inflammatory property. We evaluated the effect of CW as an adjunct therapy for patients with mild-moderate UC.
View Article and Find Full Text PDFBackground And Aims: There are no prospective studies evaluating effect of non-alcoholic fatty liver disease (NAFLD) in patients with ulcerative colitis (UC). This prospective observational study assessed the prevalence of NAFLD, its predictors, and its effect on long-term outcomes in UC.
Methods: Consecutive UC patients underwent transient elastography, body composition analysis, bone densitometry, anthropometry, and baseline demographic and subjective global assessment.
Background And Aims: Thiopurines are viable option for the treatment of inflammatory bowel disease [IBD] in resource-limited countries. However, data on the effect of disease duration at thiopurines initiation on long-term effectiveness are limited.
Method: We performed a propensity matched analysis of a retrospective cohort of patients with ulcerative colitis [UC] and Crohn's disease [CD].
Purpose: Withdrawal of thiopurines after remission is associated with an increased risk of relapse in patients with inflammatory bowel disease (IBD). However, long-term data on thiopurine withdrawal is limited, especially from developing countries where the cost of long-term therapy poses a significant burden on patients.
Methods: Patients with IBD on thiopurine monotherapy for ≥ 4 months, who stopped thiopurines while in clinical remission and were not on any other immunomodulator or biologics at the time of withdrawal, were included in this retrospective analysis.
Background And Aim: Thiopurines are widely used to maintain remission in both ulcerative colitis (UC) and Crohn's disease (CD). Reported effectiveness and tolerability rates have been variable across studies. There are only sparse data in Asian population regarding the long-term efficacy and safety of thiopurines.
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