Publications by authors named "Sandeep Gautam"

Boron toxicity is an increasingly serious problem leading to soil degradation and vegetation loss in arid and semi-arid environments worldwide. The soils of solonetzic complexes often display this characteristic. This study aimed to investigate the vertical distribution of hot water soluble-boron (hws-B) in the sodic and agricultural soils of Israna block in Haryana, India.

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Article Synopsis
  • * It focuses on the CNA-FWRD Registry, a multicenter prospective study that compares outcomes between patients receiving standard therapy and those undergoing cardioneuroablation over a follow-up period of three years.
  • * The findings aim to provide valuable data on long-term effects, recurrence of symptoms, and overall safety of cardioneuroablation, addressing a gap in existing research which is largely based on retrospective studies.
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  • The study investigates the safety of performing radiofrequency catheter ablation (RFA) for atrial fibrillation (AF) without fluoroscopy in patients who have existing cardiac implantable electronic devices (CIED).
  • Conducted over a three-year period with 225 fluoroless RFA procedures, it included 25 patients with pre-existing CIED, while monitoring any changes or complications through detailed device interrogation before and after the procedure.
  • Results showed no significant issues with the CIEDs post-procedure, indicating that fluoroless RFA is a safe option for patients with these devices, with no reported complications or necessary device revisions.
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Introduction: Radiofrequency ablation (RFA) for atrial fibrillation (AF) has been associated with variable incidence (0.88%-10%) of pericarditis manifested as chest pain, possibly more prevalent with the advent of high-power short-duration (HPSD) ablation. This has led to the widespread use of colchicine in preventative protocols for postablation pericarditis.

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  • A study compared the effectiveness and safety of cardioneuroablation (CNA) versus permanent pacing (PM) in treating recurrent cardioinhibitory vasovagal syncope (CI-VVS) in 162 patients.
  • At one-year follow-up, both treatments showed high success rates in preventing syncope, with 97% of the CNA group and 89% of the PM group meeting the primary endpoint.
  • The risk of syncope recurrence was similar for both methods, and no significant differences in adverse events were found, indicating comparable safety profiles.
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We theoretically study the stationary-state vortex lattice configurations of rotating spin-orbit (SO)- and coherently-coupled spin-1 Bose-Einstein condensates (BECs) trapped in quasi-two-dimensional harmonic potentials. The combined effects of rotation, SO and coherent couplings are analyzed systematically from the single-particle perspective. Through the single-particle Hamiltonian, which is exactly solvable for one-dimensional coupling, we illustrate that a boson in these rotating SO- and coherently-coupled condensates are subjected to effective toroidal, symmetric double-well, or asymmetric double-well potentials under specific coupling and rotation strengths.

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Cross stimulation is defined as stimulation of one cardiac chamber when the stimulation of the other chamber is expected. We present a case of an eighty three year old patient with history of dual chamber pacemaker implantation with recent generator change which showed interesting ECG findings.

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Background: Magnetic resonance imaging (MRI) in patients with MRI-conditional cardiovascular implantable electronic devices (CIED) remain a logistical issue for device programming during the scan. In current practice, a trained person needs to be present on-site to program CIED for MRI scan. This can cause delay in patient care, rescheduling of tests and increase healthcare costs.

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Background: Arterial invasive monitoring is the most common method in the USA for hemodynamic monitoring during atrial fibrillation (AF) ablation. Although studies have shown favorable comparison between non-invasive and invasive hemodynamic monitoring (IHM) in non-cardiac procedures under general anesthesia, limited data is available for complex cardiac procedures such as AF ablation in the USA. With progressive improvement in AF ablation procedural safety, particularly with routine use of intracardiac echocardiography (ICE) to monitor for pericardial effusion, it is unclear if invasive hemodynamic monitoring provides any advantage over non-invasive methods.

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Introduction: The impact of cardioneuroablation (CNA) on ventricular repolarization by using corrected QT interval (QTc) measurements has been recently demonstrated. The effects of cardiac pacing (CP) on ventricular repolarization have not been studied in patients with vasovagal syncope (VVS). We sought to compare ventricular repolarization effects of CNA (group 1) with CP (group 2) in patients with VVS.

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Background: Adequate and effective therapy for resistant vasovagal syncope patients is lacking and the benefit of cardioneuroablation (CNA) in this cohort is still debated. The aim of this study is to assess the long-term effect of CNA versus conservative therapy (CT) in a retrospectively followed cohort.

Methods: A total of 2874 patients underwent head-up tilt test (HUT) and 554 (19.

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Pepper spray is used as a crowd control agent and for self-defense. It has been thought to be safe; however, 27 persons have died in police custody after exposure to pepper spray. We report on a 21-year-old man, with no underlying heart disease and a normal ECG and echocardiogram in the past, who was pepper sprayed and developed ventricular fibrillation.

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Aims: To study the toxicological profile and anti-hyperlipidemic effects of Spondias mombin leaves methanolic extract in experimental rats.

Background: Preventing high levels of lipids or its recurrence is currently one of the key aims of clinical and experimental studies.

Objective: This study was carried out to investigate the toxicological profile and anti-hyperlipidemic effects of methanolic extract of leaves of Spondias mombin.

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Minocycline, an FDA-approved second-generation semisynthetic tetracycline, exerts antioxidant, anti-apoptotic and anti-inflammatory effects, independent of its antimicrobial properties. Interleukin (IL)-17A is an immune and inflammatory mediator, and its sustained induction is associated with various cardiovascular diseases. Here we investigated (i) whether IL-17A induces cardiomyocyte contractile depression and death, (ii) whether minocycline reverses IL-17A's negative inotropic effects and (iii) investigated the underlying molecular mechanisms.

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Purpose: Cardiac sarcoidosis is a multisystem inflammatory disorder characterized by ventricular arrhythmias. Implantable cardioverter defibrillator (ICD) is used to prevent sudden cardiac death.

Methods: We performed literature search for studies that addressed the outcome and complications of ICD in Cardiac Sarcoidosis (CS).

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Torsade de Pointes (TdP) is a rare cardiac arrhythmia that is associated with prolonged QTc interval. Hypocalcemia is a common cause of prolonged QTc. Although vitamin D deficiency (VDD) is a common disorder in elderly patients with an incidence rate of >40% and can cause hypocalcemia, it has never been linked to TdP.

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Background: The utility of protamine sulfate for heparin reversal in catheter-based atrial fibrillation (AF) ablation is unclear when using the suture closure technique for vascular hemostasis.

Objective: This study sought to address if protamine sulfate use for heparin reversal reduces vascular access complications in AF catheter ablation when suture techniques are used for postprocedural vascular hemostasis.

Methods: This is a retrospective multicenter observational study of 294 consecutive patients who underwent catheter ablation for AF with subsequent vascular access hemostasis by means of a figure-of-eight suture or stopcock technique.

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Article Synopsis
  • QRS dispersion, the difference between the longest and shortest QRS duration in an electrocardiogram, is linked to higher mortality in heart failure patients and arrhythmias in those with cardiomyopathy.
  • This study investigated whether baseline QRS dispersion could predict future cardiovascular events in individuals without prior cardiovascular disease by analyzing data from 6,510 participants.
  • Results indicated that a QRS dispersion of 34 ms or greater was significantly associated with an increased risk of major cardiovascular events and mortality, indicating its potential as a prognostic marker.
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Background: Heparin dosing of patients anticoagulated with direct oral anticoagulants (DOACs) undergoing atrial fibrillation (AF) ablation can be challenging as they require more heparin than those on warfarin therapy. We sought to compare periprocedural activated clotting times (ACTs) of patients on warfarin vs. DOAC and determine an optimal weight-based heparin dosage strategy.

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