Competitive networked bi-virus spread: Existence of coexistence equilibria.

The paper studies multi-competitive continuous-time epidemic processes. We consider the setting where two viruses are simultaneously prevalent, and the spread occurs due to individual-to-individual interaction. In such a setting, an individual is either not affected by any of the viruses, or infected by one and exactly one of the two viruses.

Management of Adult Patients With Drug Reaction With Eosinophilia and Systemic Symptoms: A Delphi-Based International Consensus.

Importance: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. To our knowledge, there is no international consensus on its severity assessment and treatment.

Objective: To reach an international, Delphi-based multinational expert consensus on the diagnostic workup, severity assessment, and treatment of patients with DRESS.

Management and treatment outcome of DRESS patients in Europe: An international multicentre retrospective study of 141 cases.

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction.

Objective: To explore treatment approaches across Europe and their impact on the disease course, as well as prognostic factors and culprit drugs.

Methods: In this retrospective European multicentric study, we included patients with probable or certain DRESS (RegiSCAR score ≥ 4) between January 2016 and December 2020.

When ethnographic work turns into distant screen visits: A note on flexible inflexibility during the COVID-19 pandemic.

This colloquium shares experiences from doing ethnographic fieldwork with young children and the challenges that followed due to the COVID-19 pandemic. The project DIGIKIDS Sweden has its focus on very young children (birth to three years) and their engagement with digital media technologies in their homes. The pandemic put the project on hold, but in the families where the fieldwork had already started, the authors decided to change the methods of data collection.

Nurses' use of social media during the COVID-19 pandemic-A scoping review.

Background: During the COVID-19 pandemic, nurses stand in an unknown situation while facing continuous news feeds. Social media is a ubiquitous tool to gain and share reliable knowledge and experiences regarding COVID-19. The article aims to explore how nurses use social media in relation to the COVID-19 pandemic.

Regulation Awareness and Experience of Additional Monitoring among Healthcare Professionals in Finland.

Background: Challenges in post-marketing adverse event reporting are generally recognized. To enhance reporting, the concept of additional monitoring was introduced in 2012. Additional monitoring aims to enhance reporting of adverse events (AE) for medicines for which the clinical evidence base is less well developed.

Perceived needs for team-based visits in Swedish child healthcare services exceed its existence-A mixed-methods study targeting healthcare professionals.

Aim: To investigate both quantitatively and qualitatively the differences between participation in team-based visits (TBVs) and perceived needs for TBVs from the perspectives of healthcare professionals, in the context of the Swedish 3-tier national Child Healthcare programme.

Methods: A study-specific questionnaire, including multiple-choice questions with fixed and free-text response options, was developed, and used. To capture healthcare professionals' experiences and find explanations for the quantitative results in qualitative data, a convergent parallel mixed-methods study design was used.

Team-based visits within Swedish child healthcare services: a national cross-sectional study.

Complex healthcare needs can be met through effective interprofessional collaboration. Since 2014, Swedish Child Healthcare Services (CHS) include universal team-based visits with a nurse and a physician who perform such visits at the age of 4 weeks, 6 months, 12 months, and 2.5 to 3 years, as well as targeted team-based visits to address additional needs.

Healthcare professionals' perceptions about interprofessional teamwork: a national survey within Swedish child healthcare services.

Background: Globally, interprofessional teamwork is described as a key method to promote health and prevent illness in children, namely, to achieve the goals of Child Healthcare Services (CHS). However, how teamwork should be designed within CHS to achieve the goals is unclear. This study aimed to investigate healthcare professionals' perceptions about 1) taking part in interprofessional teamwork, 2) team characteristics, and 3) whether the perceptions were related to professional affiliation or workplace.

A Survey of Physics-Based Attack Detection in Cyber-Physical Systems.

Monitoring the "physics" of cyber-physical systems to detect attacks is a growing area of research. In its basic form a security monitor creates time-series models of sensor readings for an industrial control system and identifies anomalies in these measurements in order to identify potentially false control commands or false sensor readings. In this paper, we review previous work on physics-based anomaly detection based on a unified taxonomy that allows us to identify limitations and unexplored challenges, and propose new solutions.

Dissipative open systems theory as a foundation for the thermodynamics of linear systems.

In this paper, we advocate the use of open dynamical systems, i.e. systems sharing input and output variables with their environment, and the dissipativity theory initiated by Jan Willems as models of thermodynamical systems, at the microscopic and macroscopic level alike.

Maximum work extraction and implementation costs for nonequilibrium Maxwell's demons.

We determine the maximum amount of work extractable in finite time by a demon performing continuous measurements on a quadratic Hamiltonian system subjected to thermal fluctuations, in terms of the information extracted from the system. The maximum work demon is found to apply a high-gain continuous feedback involving a Kalman-Bucy estimate of the system state and operates in nonequilibrium. A simple and concrete electrical implementation of the feedback protocol is proposed, which allows for analytic expressions of the flows of energy, entropy, and information inside the demon.

Distributed fault detection and isolation resilient to network model uncertainties.

The ability to maintain state awareness in the face of unexpected and unmodeled errors and threats is a defining feature of a resilient control system. Therefore, in this paper, we study the problem of distributed fault detection and isolation (FDI) in large networked systems with uncertain system models. The linear networked system is composed of interconnected subsystems and may be represented as a graph.

Advert saliency distracts children's visual attention during task-oriented internet use.

The general research question of the present study was to assess the impact of visually salient online adverts on children's task-oriented internet use. In order to answer this question, an experimental study was constructed in which 9- and 12-year-old Swedish children were asked to solve a number of tasks while interacting with a mockup website. In each trial, web adverts in several saliency conditions were presented.

Treatment of pulps in teeth affected by deep caries - A systematic review of the literature.

Background: This systematic review assesses the effect of methods commonly used to manage the pulp in cases of deep caries lesions, and the extent the pulp chamber remains uninfected and does not cause pulpal or periapical inflammatory lesions and associated tooth-ache over time.

Study Design: An electronic literature search included the databases PubMed, EMBASE, The Cochrane Central Register of Controlled Trials and Cochrane Reviews from January 1950 to March 2013. In addition, hand searches were carried out.

Pulp exposures in adults--choice of treatment among Swedish dentists.

This study comprises a survey of Swedish dentists'treatment preferences in cases of carious exposure of the dental pulp in adults.The survey was conducted as part of a comprehensive report on methods of diagnosis and treatment in endodontics, published in 2010 by the Swedish Council on Health Technology Assessment. A questionnaire was mailed to a random subsample of 2012 dental offices where one dentist at each office was requested to answer all questions.

Understanding newsworthiness of an emerging pandemic: international newspaper coverage of the H1N1 outbreak.

Background And Objectives: During an evolving public health crisis, news organizations disseminate information rapidly, much of which is uncertain, dynamic, and difficult to verify. We examine factors related to international news coverage of H1N1 during the first month after the outbreak in late April 2009 and consider the news media's role as an information source during an emerging pandemic.

Methods: Data on H1N1 news were compiled in real time from newspaper websites across twelve countries between April 29, 2009 and May 28, 2009.

Characterisation of the post-translational modifications of a novel, human cell line-derived recombinant human factor VIII.

Introduction: Host cell lines used for recombinant protein expression differ in their ability to perform post-translational modifications (PTMs). The currently available recombinant human FVIII (rhFVIII) products are produced in mammalian, non-human cell lines. For rhFVIII, glycosylation and sulfation are vital for functionality and von Willebrand factor (VWF)-binding affinity.

Functional characteristics of the novel, human-derived recombinant FVIII protein product, human-cl rhFVIII.

Introduction: Hemophilia A is routinely treated by administration of exogenous coagulation factor VIII (FVIII). As safety and efficacy of FVIII products have improved over the years, development of FVIII-neutralizing antibodies (FVIII inhibitors) has emerged as the most serious complication. The new human cell line-derived recombinant human FVIII (human-cl rhFVIII) is the first recombinant FVIII product produced in a human cell line without additive animal proteins, with a goal of minimizing the risk of inhibitor development.