Publications by authors named "Sanda Sladic"
Article Synopsis
- The study investigated how occupational physical activity (OPA) and recreational exercise (RE) are related to thyroid function in patients with Hashimoto's thyroiditis (HT).
- Researchers analyzed data from 438 HT patients, correlating thyroid-related clinical measures with self-reported physical activities.
- Findings indicated that higher OPA was linked to decreased thyroid function and increased autoimmunity, while higher RE correlated with improved thyroid metrics and higher vitamin D levels, suggesting different impacts of OPA and RE on thyroid health.
Background: In radioiodine thyroid dosimetry, the serial uptake measurements are variously analyzed, but an underlying model, derived from plausible assumptions, is lacking.
Methods: We derived that, upon oral administration, the intrathyroid iodine activity is the sum of two monoexponential functions, defined by iodine activity given, its volume of distribution, and thyroid and whole-body clearances, as well as the decay constants of the particular isotope.
Applications: The individual parameters of the model function are fitted to the patient's uptake data, allowing direct calculation of the cumulated thyroid activity and assessment of thyroid parameters which, unlike thyroid uptake, are not confounded by renal function.