Antioxidant PRDX3 gene therapy protects brain cells and prevents neurodegeneration in an animal model of Parkinson's disease.

Neurodegenerative diseases, including Parkinson's Disease (PD), are a significant global health challenge with no effective therapies to counteract neurodegeneration. Genetic and environmental factors lead to mitochondrial dysfunction and increased reactive oxygen species (ROS), resulting in oxidative stress. This stress reduces levels of Peroxiredoxin 3 (PRDX3), a key protein for maintaining ROS balance at the mitochondrial level, increasing the substantia nigra's susceptibility to damage.

Agomelatine as Antidepressant Treatment in Elderly Patients With Previous Hyponatremia Due To SSRI Use: Case Series.

Objective: To evaluate agomelatine treatment in elderly patients with major depressive disorder (MDD) who developed hyponatremia while using selective serotonin receptor inhibitors (SSRIs).

Methods: Patients (60 years or older) with hyponatremia after SSRI treatment for MDD were changed to agomelatine 50 mg/day during one month to observe sodium levels during the treatment and change in depressive symptoms. Montgomery-Asberg Depression Rating Scale (MADRS) and the Clinical Global Impression Scale (CGI) of severity were used before and after treatment with agomelatine.

Deep 3D Neural Network for Brain Structures Segmentation Using Self-Attention Modules in MRI Images.

In recent years, the use of deep learning-based models for developing advanced healthcare systems has been growing due to the results they can achieve. However, the majority of the proposed deep learning-models largely use convolutional and pooling operations, causing a loss in valuable data and focusing on local information. In this paper, we propose a deep learning-based approach that uses global and local features which are of importance in the medical image segmentation process.

A Saliency-Based Sparse Representation Method for Point Cloud Simplification.

High-resolution 3D scanning devices produce high-density point clouds, which require a large capacity of storage and time-consuming processing algorithms. In order to reduce both needs, it is common to apply surface simplification algorithms as a preprocessing stage. The goal of point cloud simplification algorithms is to reduce the volume of data while preserving the most relevant features of the original point cloud.

Sparse Regularization-Based Approach for Point Cloud Denoising and Sharp Features Enhancement.

Denoising the point cloud is fundamental for reconstructing high quality surfaces with details in order to eliminate noise and outliers in the 3D scanning process. The challenges for a denoising algorithm are noise reduction and sharp features preservation. In this paper, we present a new model to reconstruct and smooth point clouds that combine L1-median filtering with sparse L1 regularization for both denoising the normal vectors and updating the position of the points to preserve sharp features in the point cloud.

[Neural control of the peripheral circulation and blood pressure].

In the XIX century Claude Bernard discovered the action of the nervous system on the peripheral circulation. In the first half of the XX century Ewald Hering discovered the baro-receptor and the reflex control of the heart rate and blood pressure. Cowley and Guyton demonstrated that sino-aortic denervation induces persistent changes in the blood pressure in the dog.

Mechanical factors of cardiovascular risk in systemic arterial hypertension. A new sign of arterial rigidity.

Unlabelled: ANTECEDENT: By means of sphygmokinetocardiography (SKCG) we developed and arterial rigidity index (ARI) which measure the pulse wave aortic carotid reflexion time over the left ventricular ejection time (LVET). This index, together with the pulse wave velocity (PWV) and the pulse pressure (PP) are indicators of arterial stiffness. In this paper we measured these index in 27 systemic artery hypertension.

[Early arterial reflexion and ventricular extrasystole. A novel mechanism detected with sphygmokinetocardiography].

Unlabelled: ANTECEDENT: Through sphygmokynetocardiography (SKCG) an exploratory method that records an electrocardiographic signal, a carotid pulse (CP), and two vibriograms (kinetocardiograms) of the left ventricle (LV) recorded in the left hemithorax (anterior kinetocardiogram, AKC) and the subcostal region of left abdomen (posterior kinetocardiogram of PKC, vibrations transmitted through the hemidiaphragm) we observed a systolic precocious reflection wave (Rw) in the CP and prolongation of LV ejection time (LVET) measured in AKC or in PKC of the previous sinusal pre-extrasystolic beat (PEB) vs control beats (CB) in cases with ventricular extrasystoles (VEs).

Objective: To demonstrate whether the intervals just mentioned are associated with ventricular extrasystoles.

Method: Sixty cases: 30 with VEs, group A, and 30 without arrhythmia, group B, were studied through SKCG.

[A system for non-invasive measurement of arterial pulse velocity in different vascular territories].

Blood pulse wave velocity (PWV) is a known index of arterial rigidity and its measurement has proved its usefulness in the study of some cardiovascular pathologies. In this study we describe the design and implementation of a system for noninvasive PWV determination in the aorto-braqui-humero-radial (A-->h), aorto-ileo-femoro-pedial (A-->f) and aorto-carotid (A-->c) regions. This system was examined with 36 normotensives (NT) and 34 hypertensives (HT) patients with (LVH, n = 20) and without (WLVH, n = 14) left ventricular hypertrofy.

[Provocation and measurement of retrograde pulsatile wave velocity in normal subjects and patients with systemic hypertension].

Unlabelled: There are not published incruent methods of provocation and/or measurement of the velocity of the reflexive arterial pulse wave. This phenomenon is implicated in the pathogenesis of arterial hypertension. We describe that during compressive sphygmomanometry (CS) done in the forearm, reflexive waves are provoked that are register in the arm with an equipment developed by us, which measures the velocity of the antegrade (APWV) and the provoked retrograde (RPWV) pulse waves.

[The importance of radiology in the localization of pheochromocytoma].

The usefulness of different radiologic studies in localizing the tumor was evaluated in 26 patients with a firmly established diagnosis of pheochromocytoma. The site of the lesion was correctly identified in 8% of the cases by the plain abdominal x-ray films: in 11% by the plain thoracic films; in 34% by uronephrotomography; in 88% by angiography and in 6 patients (100%) in whom computed tomography scans (CT) were performed. The tumors were intra-adrenal in 19 patients and extra-adrenal in the remaining 7 cases.

Immunologic studies in patients with Takayasu's arteritis. III. Immunoregulatory changes.

Study of cellular immune function in 14 patients with Takayasu's arteritis (TKA) revealed markedly decreased active E rosettes and CD4+ cells and slightly diminished CD8 + and autologous rosette-forming T cells. They were also found to have decreased production of interleukin-2 and decreased response to interleukin-1. Patients with active disease were also found to have decreased response to IL-2.

[Takayasu arteritis: usefulness of radiologic and angiographic studies].

With the purpose of learning the usefulness of radiologic and angiographic procedures for the evaluation of Takayasu's arteritis (TA), we studied 64 patients (ratio women: 8.1, average age: 23.5 years, range: 13-52 years) in which we performed arteriographic studies in the clinically affected area.

[Left aortic arch without a circumflex segment and a right descending aorta: a hypothetical case and a real example].

We studied a case of a patent left ductus arteriosus, with a left aortic arch connected to a right descending aorta without an aortic circumflex (retroesophageal) segment. We believe this is the first world-published example of this--so far--hypothetical anomaly, included in Kirkling and Edwards classification of vascular rings. The case was a 27-year-old deaf-mute female patient with a patent left ductus arteriosus, with important left to right shunt and moderate pulmonary arterial hypertension who underwent a successful closing surgical procedure.

[Effects of a calcium antagonist (nifedipine) in hypertensive and normotensive subjects].

We investigated the effect of the calcium antagonist nifedipine upon the following parameters: systolic and diastolic blood pressure (SBP and DBP) heart rate (HR), electrocardiogram (ECG) and the relative rate of calcium uptake in platelets. The possible correlation between this rate and blood pressure was one of the main points we tried to establish. The subjects studied were 1) 26 patients with uncomplicated essential hypertension and 2) 13 healthy normotensive subjects.

[The P wave in systemic arterial hypertension. Comparison with the echocardiogram and apexcardiogram].

The cause of an abnormal electrocardiographic P wave (AEPW) in systemic arterial hypertension (SAH) has not been delucidated. In order to demonstrate if this sign is related to volume overload of the left atrial cavity -previously we found no correlation between pressure overload of the cavity and the presence of an AEPW- 34 patients with SAH were studied; population were divided in two groups: group A (GA, n = 13), formed by 13 cases with a P wave more than 0.10 s duration (D2 standard lead) and group B integrated by 21 cases with a P wave at 0.

Systemic arterial hypertension and coronary atherosclerosis. Observations in survivors of a first myocardial infarction.

To determine the importance of systemic arterial hypertension (SAH) in the pathogenesis of coronary atherosclerosis (CA), the coronary stenosis (CSI), coronary diffuse atheromatous (CDAI) and coronary tortuosity (CTI) indices were assessed by selective coronary angiography (SCA) in 132 survivors of a definite first myocardial infarction (MI). Patients were divided into 2 groups according to the absence (group A, n = 60) or presence (group B, n = 72) of SAH. Group B was further subdivided into 2 subgroups: group B1, consisting of 62 patients receiving no antihypertensive treatment before admission, and group B2, consisting of 20 patients treated continuously for at least 2 years with a diuretic or diuretic + beta-blocker.

Two factors associated with increased uptake of calcium in platelets from essential hypertensive patients.

The relative rate of calcium transport into platelets from essential hypertensive patients and healthy normotensive donors was measured using the metallochromic indicator arsenazo III and recording net decrease in optical density per 5 minutes (O.D.U.

[Myocardial infarct secondary to a non-penetrating chest injury. Presentation of a case and review of the literature].

We describe a 21 year old male who had a myocardial infarction as a result of a horse kick in the chest. EKG Showed changes compatible with anterolateral infarction. Thallium scan demonstrated diffuse decreased uptake.

[The P-wave in systemic arterial hypertension].

An abnormal electrocardiographic P wave (AEPW) has been interpreted as indicative of heart failure, hypertrophy or dilatation of left atrium, or diminished left ventricular compliance. In order to determine the significance of this electrocardiographic sign we studied 47 cases of systemic arterial hypertension (SAH) without heart failure or coronary obstruction. Patients were assigned at 2 groups: group A (22 cases with P wave duration greater than 0.