Publications by authors named "Sanaz Mehdi-Alamdarlou"
Article Synopsis
- Multiple sclerosis (MS) is a disease that mainly affects young people and causes inflammation in the body, but current treatments aren't very effective because they don't target the problem well enough.
- Platelets are special blood cells that help with healing and controlling inflammation, and they can also help in the fight against MS by recruiting other cells to the injured areas.
- Using platelets to deliver drugs directly to where they’re needed in the brain could make MS treatments better by reducing inflammation more effectively.
Dimethyl fumarate (DMF), is one of the lately approved therapeutic agents for the multiple sclerosis (MS) treatment. Despite the beneficial effects, DMF also suffers from low penetration into brain. In this study, we designed a precise drug delivery system of DMF to cross BBB for MS management.
View Article and Find Full Text PDFPatients with SARS-CoV-2 infections experience lymphopenia and inflammatory cytokine storms in the severe stage of the disease, leading to multi-organ damage. The exact pattern of immune system changes and their condition during the disease process is unclear. The available knowledge has indicated that the NF-kappa-B pathway, which is induced by several mediators, has a significant role in cytokine storm through the various mechanisms.
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