Publications by authors named "Sanaz Asgarifar"

Article Synopsis
  • - This study presents an electrophysiological sensor that can monitor and quantify how C6 glioma cells migrate and form cell-junctions in real time on electrode surfaces.
  • - The sensor captures changes in signal amplitude and frequency, allowing for accurate measurement of migration speed and differentiation between individual and collective cell movements.
  • - The technique has potential applications in cancer research, such as screening for compounds that inhibit cell migration, which could help develop new cancer treatment strategies.
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Astrocytes are neuroglial cells that exhibit functional electrical properties sensitive to neuronal activity and capable of modulating neurotransmission. Thus, electrophysiological recordings of astroglial activity are very attractive to study the dynamics of glial signaling. This contribution reports on the use of ultra-sensitive planar electrodes combined with low noise and low frequency amplifiers that enable the detection of extracellular signals produced by primary cultures of astrocytes isolated from mouse cerebral cortex.

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Ultra-sensitive electrodes for extracellular recordings were fabricated and electrically characterized. A signal detection limit defined by a noise level of 0.3-0.

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