FDA-approved cannabidiol [Epidiolex] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis.

Background: Chronic Gulf War Illness (GWI) is characterized by cognitive and mood impairments, as well as persistent neuroinflammation and oxidative stress. This study aimed to investigate the efficacy of Epidiolex, a Food and Drug Administration (FDA)-approved cannabidiol (CBD), in improving brain function in a rat model of chronic GWI.

Methods: Six months after exposure to low doses of GWI-related chemicals [pyridostigmine bromide, N,N-diethyl-meta-toluamide (DEET), and permethrin (PER)] along with moderate stress, rats with chronic GWI were administered either vehicle (VEH) or CBD (20 mg/kg, oral) for 16 weeks.

Prosthetic Management of an Eviscerated Eye of a 13-month-old Patient: A Case Report.

Background: On account of loss of eye following Rubella infection, a 13-month-old baby girl patient required a maxillofacial prosthesis to restore her facial esthetics and social health as she grows.

Case Presentation: The process of prosthesis fabrication began at the time of enucleation where a conformer was given. Post healing the procedure was completed in a span of 2 days taking adequate trials and cross references for the like-like appearance of the prosthesis.

An Assessment of the Accuracy of Recurring Esthetic Dental Proportion: An In Vivo Comparative Analysis of Maxillary Anterior Teeth Proportion With Chu's Gauge and Custom-Made Calipers.

Smile designing, in harmony with nature, has always been a challenge in dentistry. Several theories have been proposed in the past with a view to replicate an esthetic smile. One such method proposed by Dr.

Correlation of "K" plane to occlusal plane and three different ala-tragal lines in dentulous subjects with different skeletal forms: A cephalometric study.

Aim: Orientation of the occlusal plane is an important clinical procedure for complete denture fabrication. An attempt had been made to reconstruct the occlusal plane using a different reference plane. The aim of this study was to find the correlation of the "K" plane to the occlusal plane and to assess the angular deviation between the K-plane to the occlusal plane (KO) with different skeletal forms.

Evaluation of the marginal fit of full contoured zirconia, lithium disilicate and metal crowns fabricated using CAD-CAM: An study.

Introduction: The marginal fit of any dental restoration is vital to its long-term success. Lack of adequate fit is potentially detrimental to both the tooth and the supporting periodontal tissues. The purpose of this study was to evaluate the marginal fit of monolithic zirconia, monolithic lithium disilicate and monolithic metal crowns and compare the three groups.

Correlation of intercondylar distance and occlusal vertical dimension in dentate individuals: A clinical study.

Statement Of Problem: Determining the vertical dimension of occlusion for an edentulous patient depends on clinical judgment and the skill and experience of the dentist. Though many methods have been advocated, a universally accepted method of determining the vertical dimension of occlusion in edentulous patients is lacking.

Purpose: This clinical study aimed to find a correlation between the intercondylar distance and occlusal vertical dimension in dentate individuals.

An Evaluation of the Relation Between Variation in Arch Forms and Relative Parallelism of the Occlusal Plane to the Line Joining the Inferior Border of Ala of the Nose With Different Tragal Levels of the Ear in Dentulous Subjects: An In Vivo Study.

Introduction The purpose of this study was to evaluate which of the three positions on the tragus (superior, middle, and inferior), when connected to the inferior border of the ala of the nose, was the most parallel to the natural occlusal plane in dentate patients, to correlate the level of the naturally existing occlusal plane with the ala-tragal line when the tragus was divided into three portions (superior, middle, and inferior), and to determine which position in the tragus occlusal plane is the most parallel. The study also evaluated the correlation between the variation of arch forms and the relative parallelism of the occlusal plane to the ala-tragal line at different tragal levels. Methods This study included 1405 subjects between the ages of 18 and 35 years.

Prosthodontic Management of Congenital Hypothyroidism with Anodontia: A Case Report.

Thyroid dysfunction has various manifestations which include orofacial abnormalities like delayed eruption, retained deciduous teeth, etc. Early detection of this deregulation of thyroid homeostasis can prevent associated complications. This report is a case of congenital hypothyroidism (CH) in a 4-year-old boy who presented with a completely edentulous maxilla and hypodontic mandible.

Evaluation of Fracture Resistance and Color Stability of Crowns Obtained by Layering Composite Over Zirconia and Polyetheretherketone Copings Before and After Thermocycling to Simulate Oral Environment: An Study.

Background: Most common material used for the fabrication of an implant restoration is full-ceramic crown or an all-ceramic crown. Frequent chipping of the ceramic under occlusal load has posed a great problem to the clinician and the patient. Composites have been layered over zirconia successfully in the recent past to overcome this problem.

Influence of Different Zirconia Coping Designs on the Fracture Resistance of All-Ceramic Crowns: An Study.

Background And Aim: Increased demand for metal-free restorations in posterior areas has increased the focus on zirconia restorations because of its advantages in excellent mechanical properties, patient comfort, and acceptance. Although all-ceramic crowns have better biocompatibility and esthetic properties, there are some clinical reasons for the fracture of the veneer or the core materials in the posterior region. This study aims at comparing the influence of zirconia coping designs on the fracture resistance of all-ceramic crowns.

A Study to Assess the Bond Strength of Acrylic Teeth With Different Retentive Features.

Background And Aim: Flexible denture base has been gaining attention as a denture base material because of its toxicological safety, comfort, and enhanced aesthetics. Debonding of acrylic teeth from the flexible denture base material has posed a great problem to the clinician and patient. This study aimed at comparing the bond strength between flexible denture base with acrylic teeth having different mechanical modifications.

Comparison of the Bond Strength of Composite Resin to Zirconia and Composite Resin to Polyether Ether Ketone: An Study.

Aim: The aim of the study was to compare the shear bond strength of composite resin bonded to polyether ether ketone (PEEK) and zirconia, and also to evaluate the effect of thermocycling on the shear bond strength.

Materials And Methods: A total of 22 zirconia (Group 1) and 22 PEEK (Group 2) specimens (disks of 10 mm in diameter and 10 mm in thickness) were machine milled using computer-aided design (CAD)/computer-aided manufacturing (CAM) from commercially available zirconia and PEEK. These specimens were air abraded with 110-μm aluminum oxide.

A Novel Design Modification to Improve Flexural Strength of Zirconia Framework: A Comparative Experimental Study.

Aim: Zirconia-based restoration is successfully replacing metal ceramic restorations in posterior areas. Although higher mechanical properties of zirconia, their use in compromised situation is questionable. Hence, there is a need to modify the design which to strengthen the framework.

Hearing Assessment of Dental Personnel: A Cross-sectional Exploratory Study.

Aim: Dental professionals are prone to have hearing impairment due to prolonged exposure of noise in dental college. The aim of the study was to assess the hearing ability of dental personnel working in Yenepoya Deemed to be University, Mangaluru, Karnataka, India.

Materials And Methods: A cross-sectional exploratory study was conducted on 60 subjects (30 male and 30 female).

Influence of Aerated Drink, Mouthwash, and Simulated Gastric Acid on the Surface Roughness of Dental Ceramics: A Comparative Study.

Background: Dental ceramics are known for their natural appearance and their durable chemical and optical properties, and their uses mainly reflect their excellent aesthetic properties, biocompatibility and resistance to wear. In addition, dental ceramics are considered to be chemically inert restorative material with large differences in the chemical compositions and microstructures. Although ceramics exhibit excellent physical properties and biocompatibility, the oral environment presents a series of external factors that affect its physical and mechanical properties in its long term function.

Nasal reconstruction with silicone using customised impression technique.

Facial defects can result from a variety of reasons including trauma, burns, infections, congenital disorders, and neoplasms which require surgical correction or prosthetic rehabilitation or both. Prosthetic replacement using various materials is the treatment of choice when other surgical options are not possible. This report presents a case of acquired nasal defect secondary to a surgically operated adenoid cystic carcinoma using silicone as the material of choice.

A clinico-radiographic study to compare and co-relate sagittal condylar guidance determined by intraoral gothic arch tracing method and panoramic radiograph in completely edentulous patients.

Purpose: The purpose of this study was to compare and correlate sagittal condylar guidance determined by intraoral gothic arch tracing method and panoramic radiograph in edentulous patients.

Materials And Methods: Twelve completely edentulous patients were selected by the inclusion and exclusion criteria. Conventional steps in the fabrication of complete denture till jaw relation were carried out.

An Study to Compare and Evaluate the Correlation of the Facial Measurements with the Combined Mesiodistal Width of the Maxillary Anterior Teeth between Males and Females.

Aim: The aim of this study was to compare and evaluate the correlation of the facial measurements (interalar, intercommissural, intercanthal, and interpupillary distance) with the combined mesiodistal width of the maxillary anterior teeth between males and females.

Objectives: The objectives of this study were: (a) To evaluate the correlation of the facial measurements (interalar, intercommissural, intercanthal, and interpupillary distance) and combined mesiodistal width of maxillary anterior teeth. (b) To compare the correlation of the facial measurements (interalar, intercommissural, intercanthal, and interpupillary distance) with the combined mesiodistal width of maxillary anterior teeth between males and females.

Excision Versus Fixation of the Radial Head: A Comparative Study of the Functional Outcomes of the Two Techniques.

Introduction: The management of displaced and comminuted radial head fractures has been a matter of debate amongst surgeons for many years. Radial head excision formed the mainstay of surgical management of these injuries. Over the years, there have been improvements in the surgical techniques and availability of better implants and instrumentation techniques, hence, open reduction and internal fixation of these fractures is gaining popularity.

To Operate or not to Operate the Mid-Shaft Fractures of the Clavicle: A Comparative Study of Functional Outcomes of the Two Methods of Management.

Introduction: Fractures of the clavicle are some of the most common fractures which are seen in the adult population. Mid-shaft fractures of the clavicle are considered the most common form of clavicle fractures and about half of them are displaced fractures. They have been managed non-operatively over the years.

Accidental Bolt Gun Injury to Femur - A Case Report.

Introduction: Bolt gun or slaughterer's guns are used in meat industry for "humane killing" of animals. Injuries caused by bolt gun are rare, reported exclusively from central European countries. We report a case of 28 year old male, who accidentally shot himself with a bolt gun to his right thigh.

Evaluation of accuracy of transfer of the maxillary occlusal cant of two articulators using two facebow/semi-adjustable articulator systems: An in vivo study.

Aim: The aim of this study was to compare the accuracy of the angle made by Frankfort horizontal plane-occlusal plane on maxillary casts, mounted using the respective facebows on Artex Amann Girrbach and Hanau Wide-vue semi-adjustable articulators with cephalometrically derived Frankfort horizontal plane-occlusal plane angle as a control.

Subjects And Methods: Maxillary casts of 30 subjects were mounted on Hanau Wide-vue and Artex Amann Girrbach semi-adjustable articulators following facebow transfer using respective facebows. The Frankfort horizontal plane-occlusal plane angles of these casts were measured using Wixey's digital angle gauge.

Prosthetic rehabilitation of an orbital defect for a patient with hemifacial atrophy.

Removal of an eye may be indicated in cases of congenital abnormality, severe trauma, or disease such as an infection, tumor, or malignancy. The disfigurement associated with a loss of an eye is often accompanied with physical problems, psychological trauma, and a poor quality of life. A prosthetic replacement is the treatment of choice to return the individual to his normal vocation by producing an acceptable and life-like appearance.

An evaluation of relation between the relative parallelism of occlusal plane to ala-tragal line and variation in the angulation of Po-Na-ANS angle in dentulous subjects: A cephalometric study.

Aims: The aim was to evaluate if any correlation exists between variation in angulation of Po-Na-ANS angle and relative parallelism of the occlusal plane to the different tragal levels of the ear in dentulous subjects.

Methodology: A total of 200 subjects were selected for the study. A custom made occlusal plane analyzer was used to determine the posterior point of the ala-tragal line.