Publications by authors named "Sanada K"

Background: Resistance training is a well-known exercise therapy for preventing and improving lacks of muscle mass, strength, and quality with advances in age; however, its effects on arterial stiffness are not beneficial. Additionally, a higher intake of protein, which is an effective nutrient for muscle health, results in lower arterial stiffness. Whether the combination of moderate to high-intensity resistance training and high-protein intake would improve muscle mass, strength, and quality and cancel the resistance training-induced increase in arterial stiffness in elderly women remains unclear.

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Background: Sarcopenic obesity (SO) is defined as a decrease in lean body mass and an increase in body fat mass (BFM) due to aging. Detecting SO in elderly women is important from the perspective of extending healthy life expectancy. While various indices of SO are currently used, there is no global consensus regarding diagnostic criteria for SO.

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Article Synopsis
  • Sarcopenic obesity is the combination of obesity and sarcopenia in individuals aged 40-75 years, requiring specific diagnostic criteria for the Japanese population.
  • The diagnostic process involves a two-step algorithm: screening for obesity using waist circumference/BMI and evaluating sarcopenia with tests like the finger ring test along with the Asian Working Group criteria.
  • Final diagnosis includes assessing muscle strength (handgrip test), physical function (chair stand test), and muscle mass, with sarcopenic obesity classified into Stage I and Stage II based on severity and complications.
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This study investigated the effects of white meat, such as chicken, intake combined with resistance training on muscle mass and strength in the elderly women, and whether the underlying mechanism involves changes in the gut microbiota. Ninety-three volunteers (age 59-79 years) were randomly allocated to sedentary control with placebo (Sed + PL) or chicken meat (Sed + HP) and resistance training with placebo (RT + PL) or chicken meat (RT + HP). Resistance training sessions were performed 3 d/week for 12 weeks using leg extensions and curls.

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Background: Previous research has shown a significant link between gut microbiota in children with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). However, much remains unknown because of the heterogeneity of disorders and the potential confounders such as dietary patterns and control group variations.

Methods: Children aged 6-12 years who had been clinically diagnosed with ASD and/or ADHD, their unaffected neurotypical siblings, and non-related neurotypical volunteers were recruited cross-sectionally.

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  • The study is a retrospective cohort analysis focused on the effectiveness of balloon kyphoplasty (BKP) for treating vertebral compression fractures (VCFs) in patients with diffuse idiopathic skeletal hyperostosis (DISH).
  • A total of 72 patients were examined, with 21 having DISH and 51 without, to assess factors like back pain improvement, adjacent fracture incidence, and reoperation rates.
  • Results showed that BKP improved back pain in both groups and had similar rates of subsequent fractures and reoperations, though local kyphosis increased significantly in the DISH group, indicating BKP's potential benefits despite complications.
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Background: The impact of the gut microbiota on neuropsychiatric disorders has gained much attention in recent years; however, comprehensive data on the relationship between the gut microbiome and its metabolites and resistance to treatment for depression and anxiety is lacking. Here, we investigated intestinal metabolites in patients with depression and anxiety disorders, and their possible roles in treatment resistance.

Results: We analyzed fecal metabolites and microbiomes in 34 participants with depression and anxiety disorders.

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Solubility enhancement is a key issue for developing the perylene diimide-based functional materials. Introduction of curved structure proved an effective solubilizing method without employing steric repulsion. In this work, wavily curved perylene diimides were developed as a new family of highly soluble curved perylene diimides.

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Introduction: There are few reports of cases with vertical subluxation. We report our experience of a vertical subluxation of the atlantoaxial joint caused by infection.

Case Report: A 63-year-old man had a 5-month history of neck pain.

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A 73-year-old man was referred to our hospital for anemia. He underwent a colonoscopy; a 15-mm Ip polyp and a 30- mm type 1 lesion were found in the sigmoid colon. Pathological examination results indicated a well-differentiated adenocarcinoma.

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Introduction Schizophrenia symptom severity is linked to neuroinflammation. Certain blood cell indexes such as neutrophil-lymphocyte ratio (NLR) and neutrophil-albumin ratio (NAR) have been used as biomarkers in various diseases, including schizophrenia. In acute clinical practice, it is challenging to decide whether to provide intravenous antipsychotic treatment in some cases due to the lack of objective biomarkers of psychiatric symptoms.

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Background: Growing attention is paid to the association between alterations in the gut microbiota and their metabolites in patients with psychiatric disorders. Our study aimed to determine how gut microbiota and metabolomes are related to the sleep quality among patients with depression and anxiety disorders by analyzing the datasets of our previous study.

Methods: Samples were collected from 40 patients (depression: 32 patients [80.

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  • Kawasaki disease is a systemic vasculitis that requires the evaluation of both coronary and systemic arteries, and this study aimed to assess the effectiveness of non-contrast magnetic resonance angiography (NC-MRA) in detecting complications related to the disease.* -
  • The study involved 28 patients, with 57 exams focused on coronary arteries and 42 exams that included both coronary and systemic artery assessments, finding high image quality for various systemic arteries.* -
  • Results showed no significant differences in examination time or sedation dosages between protocols and identified systemic artery aneurysms in 7.1% of patients, demonstrating the feasibility of a combined examination approach.*
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High cardiorespiratory fitness levels achieved through regular aerobic exercise are associated with reduced cardiometabolic risk. The exercise-induced myokine irisin possibly mediates these associations, but these relationships are unclear. This study aimed to clarify the relationships between circulating irisin levels, cardiorespiratory fitness levels, and cardiometabolic risk factors adjusted for sex and age.

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Study Design: This study adopted a retrospective cohort study design.

Purpose: This study aimed to clarify the influence of diffuse idiopathic skeletal hyperostosis (DISH) on bone fusion after transforaminal lumbar interbody fusion (TLIF).

Overview Of Literature: The negative effects of DISH on lumbar degenerative diseases have been reported, and DISH may be involved in the onset and severity of lumbar spinal canal stenosis.

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Fibromyalgia (FM) is a syndrome characterized by chronic pain with depression as a frequent comorbidity. However, efficient management of the pain and depressive symptoms of FM is lacking. Given that endogenous oxytocin (OXT) contributes to the regulation of pain and depressive disorders, herein, we investigated the role of OXT in an experimental reserpine-induced FM model.

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Objective: This study aimed to investigate the relationship between physical activity (PA) of moderate to vigorous intensity (MVPA) and in older Japanese adults. We evaluated the amount of PA using an activity meter equipped with a three-axis accelerometer. The measured activities were classified into locomotive PA and non-locomotive PA to clarify not only the relationship between MVPA and , but the types of activities that lead to increased as well.

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[Purpose] The purpose of this study was to examine the relationships between physical, cognitive, and social frailty and locomotive and non-locomotive physical activity of moderate to vigorous intensity in community-dwelling older adults and to explore effective intervention methods for preventing frailty. [Participants and Methods] Participants were 82 community-dwelling Japanese older males and females. Measurement items included basic information (age, gender, height, weight, body mass index, and the number of underlying diseases), physical activity, and assessment of physical, cognitive, and social frailty.

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Background: Although gamma-aminobutyric acid-benzodiazepine (GABA-BZ) receptor agonists are used to treat insomnia, their long-term or high-dosage use causes adverse events. Nevertheless, evidence regarding the discontinuation and replacement of GABA-BZ receptor agonists with alternative agents is lacking. Suvorexant (SUX), an existing orexin receptor antagonist, is effective in preventing nocturnal awakening in 70%-75% of patients with insomnia.

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Article Synopsis
  • - The intestinal immune system interacts with beneficial gut bacteria to keep a healthy balance, but stress can disrupt this balance and negatively affect brain function.
  • - Researchers found that a specific type of immune cell (γδ T cells) in the colon affects how individuals respond to chronic social stress, especially through a receptor called dectin-1.
  • - Reduced levels of certain beneficial bacteria, like Lactobacillus, lead to stress-related behavior changes, similar to those observed in people with depression, indicating a link between gut health and mental health.
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Due to the environmental risks of conventional Cu-based fungicides, Cu-loaded chitosan nanoparticles have been developed as nano-pesticides, aiming to protect plants against different diseases. In this sense, the objective was to verify the effects of chitosan nanoparticles containing Cu ions on leaf discs of cv. IPR 100 infected with .

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This study aimed to investigate the interaction between sarcopenic obesity and locomotive and nonlocomotive physical activity (PA) on the risk of depressive symptoms in community-dwelling older Japanese women. Participants were 143 community-dwelling older women aged 64-94 years. PA was measured using a three-axis accelerometer.

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[Purpose] Very few studies have been conducted on the benefits of water exercise for older adults with sarcopenic obesity. Whether the water exercise intervention is effective for improving sarcopenia and/or obesity remains unclear. This study aimed to investigate the effects of water exercise on body composition and components of metabolic syndrome in older females with sarcopenic obesity.

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We aimed to investigate the impact of aging on the relationship among the composition of gut microbiota, gastrointestinal (GI) symptoms, and the course of treatment for major depressive disorder (MDD) by analyzing the datasets from our previous study. Patients with MDD were recruited, and their stools were collected at three time points (baseline, midterm, and endpoint) following the usual antidepressant treatment. Gut microbiota were analyzed using 16S rRNA gene sequencing.

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This study aimed to investigate whether the overlap of physical, cognitive, and social frailty affects Ikigai in community-dwelling Japanese older adults. Participants were 116 community-dwelling older adult Japanese men and women. Associations of physical, cognitive, and social frailty with falls, daily living assessment, and Ikigai were analyzed by group comparisons and multivariate analyses.

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