The Effect of Oxytocin on Intracellular Ca Release in Cardiac Cells.

Ca signaling is vital for the proper functioning of all cells, including cells of the cardiovascular system. Membrane receptors for many hormones trigger intracellular Ca signaling via the activation of phospholipase C and production of inositol-1,4,5-trisphosphate (InsP). Several research groups have demonstrated the expression of oxytocin (OXT) and oxytocin receptors (OXTR) in the heart and suggested a cardioprotective role of OXT against several pathological conditions.