The Pain Research Enrichment Program (PREP): Developing an immersive program for research assistants at an academic medical center.

Research experience is often important for academic and career development. This paper describes the implementation and impact of a training program for temporary research assistants (RAs) at an academic medical center. The program includes a 9-month didactic lecture series covering research and professional development skills, a Quality Improvement project focused on improving research processes, and manuscript writing.

Effect of ankle versus thigh tourniquets on post-operative pain in foot and ankle surgery.

Background: Tourniquets are commonly used in elective extremity orthopaedic surgery to reduce blood loss, improve visualization in the surgical field, and to potentially reduce surgical time. There is a lack of consensus in existing guidelines regarding the optimal tourniquet pressure, placement site, and duration of use. There is a paucity of data on the relationship between the site of a tourniquet and postoperative pain in foot and ankle surgery.

Understanding facilitators of research participation among adults with self-reported chronic pain - a survey examining hypothetical research participation.

Background: An inability to successfully recruit participants into clinical research has consequences that negatively affect the conduct and reliability of research studies. Understanding facilitators of research participation, namely motives for participation and preferred research outcomes, may improve recruitment and retention of clinical trials related to chronic pain. The present study explored research participation facilitators among individuals with chronic pain and their association with demographic characteristics, pain-related characteristics, and factors related to future research engagement.

Amrubicin encapsulated PLGA NPs inhibits the PI3K/AKT signaling pathway by activating PTEN and inducing apoptosis in TMZ-resistant Glioma.

Glioblastoma (GBM) remains a challenging malignancy due to its aggressive nature and the lack of efficacious therapeutic interventions. Nanotechnology-based approaches exhibit promise in GBM treatment; however, the successful translation of these strategies from preclinical models to clinical settings is hindered by inefficient nanoparticle clearance from vital organs. Addressing this concern, we investigated the therapeutic potential of amrubicin (AMR) encapsulated within poly (lactic-co-glycolic acid) nanoparticles (AMR-PLGA-NPs) in combating temozolomide (TMZ) resistant GBM.

Preferences for risks and benefits of treatment outcomes for chronic low back pain: Choice-based conjoint measure development and discrete choice experiment.

Introduction: Understanding individual patient preferences for chronic low back pain (cLBP) outcomes is essential for targeting available therapeutic options; yet tools to elicit patient outcome preferences are limited.

Objective: To develop and test a choice-based conjoint (CBC) measure, commonly used in behavioral economics research, to elicit what outcomes patients with cLBP want to achieve and avoid.

Design: We developed a survey-based CBC measure to allow patients to make risk/benefit trade-off choices between possible treatment outcomes.

Implementing a mentoring program for clinical research professionals: A novel professional development initiative for university health research staff.

Clinical and translational research relies on a well-trained workforce, but mentorship programs designed expressly for this workforce are lacking. This paper presents the development of a mentoring program for research staff and identifies key programmatic outcomes. Research staff participating in this program were matched with a senior mentor.

Secretory phospholipase (sPLA-IIA) regulates breast cancer stem cells differentiation and metastatic potential.

Breast cancer is the second most cancer worldwide in females. The primary factor responsible for tumor recurrence is the presence of breast cancer stem cells (BCSCs), which escape the chemo-radiotherapy. In this study, we have investigated the role of Secretory phospholipase-A2 Group 2A (sPLA-IIA) that is overexpressed in BCSCs of MCF7 and MDA-MB-231 breast cancer cell lines.

Bleomycin loaded exosomes enhanced antitumor therapeutic efficacy and reduced toxicity.

Background: Bleomycin (BLM) is a chemotherapeutic agent with potent antitumor activity against the tumor. However, lung fibrosis is the main drawback that limits BLM use. Tumor targeted, safe, efficient and natural delivery of BLM is important to increase the effectiveness and reduce the toxic side effects.

Physical Therapy Interventions of an Electrical Burn Injury-Afflicted Patient: A Case Report.

Electrical injuries are uncommon but not completely rare. It is most prevalent in the male population, although females are also affected in the workplace or household-related activities. These injuries usually occur in situations where proper precautions are not taken by the individual and also appropriate safety drills and education for personnel are not carried out.

Catastrophic Perforation in Streptococcus Pneumoniae Aortitis: Complications of Infective Endocarditis in the Current Antimicrobial Era.

Infectious aortitis is an uncommon but life-threatening cause of aortitis. Given the lack of specific symptoms, establishing the diagnosis is often a challenge. When it is associated with an endovascular infection, such as infective endocarditis, blood cultures may be diagnostic although often limited by low positive predictive value.

Phytochemical, Histochemical and Antimicrobial Study of Various Solvent Extracts of (J. Koenig) Sm. and D. Don.

Objectives: Costaceae family comprises many ornamental and medicinal plants used for different diseases. This investigation includes the phytochemical, histochemical, and antimicrobial study of (J. Koenig) Sm.

A Comparative Assessment of the Effect of Professional Oral Hygiene Measures on the Periodontal Health of Patients Undergoing Fixed Orthodontic Appliance Therapy.

Background: Fixed orthodontic treatment provides good alignment and improves the maxilla-mandibular and dentoalveolar function. The present study was conducted to evaluate fixed orthodontic patients' periodontal condition with professional oral hygiene measures.

Materials And Methods: One-hundred and twenty patients undergoing fixed orthodontics were included in the study, divided with 60 patients in the control group (Group I) and the other 60 in the experimental group (Group II).

Facemask Therapy in Unilateral Cleft Lip and Palate Patients.

Background: Midfacial hypoplasia is a common feature in patients with combined cleft lip and palate. The current study was done to assess the effect of facemask (FM) therapy in patients with unilateral cleft palate.

Materials And Methods: A total of 16 patients with unilateral complete cleft lip and palate were treated with maxillary transversal discrepancy with rapid maxillary expansion (RME) followed by FM therapy.

Miniscrew Implant supported Maxillary Canine Retraction with and without Corticotomy Facilitated Orthodontics (CFO).

Introduction: The purpose of the study was to scientifically test maxillary canine retraction assisted by miniscrew implant with corticotomy-facilitated orthodontics.

Materials And Methods: Fifteen patients (six males, nine females) who had Class II division malocclusion with enhanced overjet were included in the study. Maxillary first premolars were surgical displaced along with retraction of maxillary.

Long non-coding RNA RP5-821D11.7 promotes proliferation, migration, and epithelial-mesenchymal transition in glioma and glioma stem-like cells.

Long noncoding RNA (lncRNA) has been recently revealed as a main regulatory molecule, which implicates many cellular functions. Studies showed that lncRNA abnormally expressed and involved in the progression and tumorigenesis of glioma. Present study identified a novel lncRNA associated with glioma, glioma stem-like cells (GSCs), and then revealed their potential functions.

Adverse Drug Reaction Profile of Anticancer Agents in a Tertiary Care Hospital: An Observational Study.

Background: Anti-cancer agents are known to be toxic, leading to a number of adverse drug reactions (ADRs). ADRs not only increase the financial burden on the patient/healthcare system but also decrease the quality of life. Understanding the burden of ADR will help strengthen the knowledge on patient safety and implement intervention strategies to reduce it.

Validation of an on-screen application-based measurement of shoulder range of motion over telehealth medium.

Background: Shoulder range-of-motion (ROM) assessment is vital for the follow-up evaluation of operated patients and for the outcome-based research studies. The aim of this study was to investigate the accuracy and reliability of a remote on-screen application (app)-based method of shoulder ROM measurement through a telehealth medium.

Materials And Methods: A consultant shoulder surgeon, a board-certified orthopedic resident, and a graduate medical doctor served as the examiners.

Predicting Molecular Subtypes of Breast Cancer with Mammography and Ultrasound Findings: Introduction of Sono-Mammometry Score.

We studied the correlation of sonographic and digital mammographic features with molecular classification of breast cancer. Imaging features from 313 patients with preliminary ultrasound and digital mammogram between November 2017 and May 2020 were compared with histopathology and immunohistochemical analysis for the prediction of molecular classification of breast cancer. We also devised a score called "sono-mammometry" score consisting of few simple imaging features which can easily be performed in outpatient settings.

Management of Acute Kidney Injury in Coronavirus Disease 2019.

Acute kidney injury is a common complication in hospitalized patients with coronavirus disease 2019. Similar to acute kidney injury associated with other conditions such as sepsis and cardiac surgery, morbidity and mortality are much higher in patients with coronavirus disease 2019 who develop acute kidney injury, especially in the intensive care unit. Management of coronavirus disease 2019-associated acute kidney injury with kidney replacement therapy should follow existing recommendations regarding modality, dose, and timing of initiation.

Metabolic Syndrome In Young Rheumatoid Arthritis Patients.

Background: Metabolic Syndrome is strongly associated with Rheumatoid Arthritis, which significantly increases cardiovascular complications and hence morbidity and mortality. Treating Metabolic Syndrome decreases cardiovascular related disease flares and deaths. This study evaluates prevalence of metabolic syndrome in young Rheumatoid Arthritis patients.