Isoniazid and Rifampicin Resistance-Conferring Mutations in Isolates from South Africa.

Tuberculosis (TB), caused by (), remains a significant global health issue, with high morbidity and mortality rates. The emergence of drug-resistant strains, particularly multidrug-resistant TB (MDR-TB), poses difficult challenges to TB control efforts. This comprehensive review and meta-analysis investigated the prevalence of and molecular insights into isoniazid (INH) and rifampicin (RIF) resistance-conferring mutations in isolates from South Africa.