Publications by authors named "Sana Haider"
Article Synopsis
- Early phase clinical trials (EPCTs) are essential for providing new treatments to patients with limited options, but culturally and linguistically diverse (CALD) and socially disadvantaged patients have lower participation rates in these trials.* -
- A 10-year review of 233 patients at Liverpool Hospital showed that 39% were CALD, with a significant percentage living in areas of socioeconomic disadvantage, indicating a disconnect between trial participants and the local population.* -
- The findings highlight the underrepresentation of CALD patients in EPCTs and suggest that their socioeconomic status may influence their access to these clinical trials, calling for strategies to improve participation.*
Carrageenan (CG) and ion exchange resins (IERs) are better metal chelators. Kappa (κ) CG and IERs were synthesized and subjected to copper ion (Cu) adsorption to obtain DMSCH/κ-Cu, DC20H/κ-Cu, and IRP69H/κ-Cu nanocomposites (NCs). The NCs were studied using statistical physics formalism (SPF) at 315-375 K and a multilayer perceptron with five input nodes.
View Article and Find Full Text PDFTo investigate the role of phosphorylation in SARS-CoV-2 infection, potential therapeutic targets and its harmful genetic sequences. Data mining techniques were employed to identify upregulated kinases responsible for proteomic changes induced by SARS-CoV-2. Spike and nucleocapsid proteins' sequences were analyzed using predictive tools, including SNAP2, MutPred2, PhD-SNP, SNPs&Go, MetaSNP, Predict-SNP and PolyPhen-2.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluates different prognostic scoring systems to predict survival in patients participating in early phase clinical trials for advanced cancer at Liverpool Hospital between 2013 and 2023.
- Data from 218 patients revealed an overall median survival of 9.8 months, with a notable 22% experiencing death within 90 days, while 17-34% were classified as high-risk.
- Among the five scoring systems tested, the MD Anderson Cancer Center score showed the best predictive ability, but all systems were similarly effective, suggesting that these scores could enhance patient selection in clinical trials.
Objective: Dental anomalies (DA) can affect paediatric patients' aesthetics, function, and psychological well-being. There is a lack of data about the prevalence of DA in children in Kuwait. This study aimed to investigate the prevalence and distribution of DA amongst schoolchildren aged 8 to 12 years.
View Article and Find Full Text PDFBackground and objectives: COVID-19 patients exhibit a broad range of manifestations, presenting with a flu-like respiratory tract infection that can advance to a systemic and severe disease characterized by pneumonia, pulmonary edema, severe damage to the airways, and acute respiratory distress syndrome (ARDS, causing fatality in 70% of COVID-19 cases). A ‘cytokine storm’ profile is found in most severely influenced COVID-19 patients. The treatment protocol of the disease also includes tocilizumab, which is a humanized monoclonal antibody used to treat autoimmune and inflammatory conditions.
View Article and Find Full Text PDFImmunotherapy (IO), involving the use of immune checkpoint inhibition, achieves improved response-rates and significant disease-free survival for some cancer patients. Despite these beneficial effects, there is poor predictability of response and substantial rates of innate or acquired resistance, resulting in heterogeneous responses among patients. In addition, patients can develop life-threatening adverse events, and while these generally occur in patients that also show a tumor response, these outcomes are not always congruent.
View Article and Find Full Text PDFThe irrational use of antimicrobials has enormously contributed to antimicrobial resistance (AMR) globally and especially in the developing world. To assess the knowledge and perception regarding AMR and antimicrobial stewardship (AMS), a descriptive cross-sectional study was carried out in university students enrolled in pharmacy, veterinary, and biology programs by using an online self-administered questionnaire. The Chi-square and Fisher exact tests (where applicable) were performed to assess the association of the demographics with the students' knowledge and perception regarding AMR and AMS.
View Article and Find Full Text PDFBackground: Patients with advanced malignancy are often on medications for co-morbidities, including those for primary or secondary prevention. The benefit from these medications can be limited and may result in adverse effects, interact with medications used for the malignancy or associated symptoms, increase pill burden and reduce quality of life.
Aims: To evaluate the proportion of patients with advanced malignancy that were continued on low or limited value medications and identify the factors associated with this.