Extraction, Purification, Characterization, and Wound Healing Effects of Novel Prickly Pear ( (L.) Mill.) Heteropolysaccharides.

The present study undertakes the purification of a novel polysaccharide from Tunisian prickly pear (L.) Mill.) rackets (PPPRs) and the determination of its physicochemical properties, structure, antibacterial and antioxidant properties, as well as its in vitro and in vivo wound healing potential.

Extraction, Characterization, and Structure of a Novel Heteropolysaccharide from Lepidium sativum and Its Effects on Wound Healing in Diabetic Rats.

The present study undertakes the extraction of a novel polysaccharide from Lepidium sativum (PLS) and the determination of its physicochemical composition and antioxidant properties, as well as its potential wound healing activity in alloxan-induced diabetic rats. This polysaccharide presented a lighter natural color, whose luminosity (∗), red-green intensity (∗), and blue-yellow intensity (∗) were recorded at 63.26, 5.

A novel probiotic strain, Lactiplantibacillus plantarum LC38, isolated from Tunisian camel milk promoting wound healing in Wistar diabetic rats.

Antimicrobial and probiotic properties were sought in Tunisian raw camel milk. One hundred and forty strains were isolated for this purpose. Initially, a screening based on growth kinetics under gastrointestinal tract (GIT) conditions allowed us to select only one strain that showed good resistance to pH 3 and 5% bovine bile.

Development and Evaluation of the Wound Healing Effect of a Novel Topical Cream Formula Based on Extract on Wounds in Diabetic Rats.

Despite advances in diabetes care, impaired diabetic wound healing remains a significant clinical problem. The present study was aimed at developing a novel cream based on extract and investigating its wound healing effect on full-thickness wounds in diabetic rats. The topical formulated oil-in-water emulsion-based cream contains aqueous extract in an amount of about 1% to 5% as an active agent.

The Effect of Prickly Pear, Pumpkin, and Linseed Oils on Biological Mediators of Acute Inflammation and Oxidative Stress Markers.

Medicinal plants have been used as a source of effective and safe alternative therapeutic agents for various ailments including inflammation. In fact, the aim of this study is to assess the topical anti-inflammatory and antioxidative potential effects of (pumpkin), (linseed), and (prickly pear) oils on acute inflammation using carrageenan-induced paw edema model. The study was conducted on 36 rats splitted in 6 groups: a normal control group and 5 carrageenan-treated groups (1%), each treated with either a normal saline, the reference drug ("Inflocine®" 2 mg/paw), pumpkin, linseed, or prickly pear oils (25 l/paw).

A novel blue crab chitosan/protein composite hydrogel enriched with carotenoids endowed with distinguished wound healing capability: In vitro characterization and in vivo assessment.

This work aimed to the development of chitosan and protein isolate composite hydrogels, for carotenoids-controlled delivery and wound healing. By increasing the concentration of the protein isolate, chitosan hydrogels were more elastic at a protein isolate concentration not exceeding 15% (w/w). Chitosan-protein isolate composite hydrogels revealed low cytotoxicity towards MG-63 osteosarcoma cells.

Falkenbergia rufolanosa polysaccharide - Poly(vinyl alcohol) composite films: A promising wound healing agent against dermal laser burns in rats.

This work was conducted to evaluate the compatibility between physicochemical, antioxidant and morphological properties of polysaccharide (FRP) extracted from red marine alga Falkenbergia rufolanosa reinforced by poly (vinyl alcohol) (PVA) composed films at different ratios of FRP/PVA: F1 (70:30), F2 (50:50), F3 (30:70) and PVA (100% PVA) and the potential wound healing effects. As assessed, FRP/PVA prepared films were heterogeneous, slightly opaque with a rough surface as ascertained by Fourier transform infrared spectroscopy, scanning electron microscopy and colorimetric parameters. Even, X-ray diffraction and glass transition results revealed a semi-crystalline structure of FRP composed films which decreased with increasing PVA ratios.

Novel Sorghum bicolor (L.) seed polysaccharide structure, hemolytic and antioxidant activities, and laser burn wound healing effect.

This work was undertaken to determine the structural characteristics of a novel polysaccharide, Sorghum Water-Soluble Polysaccharide (SWSP), extracted from Sorghum (Sorghum bicolor (L.)) seeds and to assess its in vitro hemolytic and antioxidant activities as well as its in vivo wound healing ability to treat burns induced by fractional CO laser. Results obtained by C, H and HSQC Nuclear magnetic resonance (NMR) indicated that SWSP showed the characteristic bands of polysaccharides.

Syzygium Aromaticum Alleviates Cerium Chloride-Induced Neurotoxic Effect In The Adult Mice.

Previous studies have brought to light the toxic effect of cerium chloride (CeCl) but very little is known about the oxidative brain injury caused by this metal. Medical plants have a well-recognized role in the management of damage caused by pollutants such as CeCl. Syzygium aromaticum, a potent natural source of bioactive compounds and rich in secondary metabolites, has a broad range of biological functions.

Exploring the Leaves Hemostatic and Wound-Healing Potential.

The present paper investigated the efficiency of on hemostatic and wound healing activities. leaf extracts were evaluated for their antibacterial and antioxidant effects as well as their flavonoid and polyphenol content. The hydroethanolic extract (EtOH-HOE), showing the most potent antibacterial and antioxidant activities , thanks to its flavonoid and polyphenol richness, was selected for hemostatic and wound healing evaluation.

Evaluation of dermal wound healing activity and in vitro antibacterial and antioxidant activities of a new exopolysaccharide produced by Lactobacillus sp.Ca.

The present study aimed to evaluate the in vitro antibacterial and antioxidant activities and the in vivo wound healing performance of a noval exopolysaccharides (EPS-Ca) produced by Lactobacillus sp.Ca strain. The results showed that EPS-Ca had a potential antioxidant activity determined through four different assays: DPPH scavenging activity, reducing power, β-carotene bleaching by linoleic acid assay, and Metal chelating activities.

In Vivo Evaluation of the Anti-Inflammatory Effect of Fruit Oil and Its Effects on Oxidative Stress.

In order to find new topical anti-inflammatory agents, we had recourse to a medicinal plant. This work was designed to determine the topical anti-inflammatory effect of fruit oil (PLFO), using carrageenan-induced paw edema rat model, and to evaluate its effects on oxidative stress. The topical anti-inflammatory activity of PLFO was compared to Inflocine® and estimated by measuring the diameter of paw edema, for 5 hours at a 1-hour interval.

Chemical composition, phytochemical constituents, antioxidant and anti-inflammatory activities of Urtica urens L. leaves.

Objective: The aim of this study was to investigate the chemical composition and antioxidant properties of Urtica urens L.(Uu) as well as its anti-inflammatory effect on carrageenan (CARR)-induced paw oedema in rats.

Methods: The leaves were extracted using ethanol (EtOH) and water.

Antioxidant and hemolytic activities, and effects in rat cutaneous wound healing of a novel polysaccharide from fenugreek (Trigonella foenum-graecum) seeds.

The aim of this work was to evaluate the antioxidant and hemolytic activities as well as the in vivo wound healing performance of a novel polysaccharide (FWEP) extracted from fenugreek (Trigonella foenum-graecum) seeds. The antioxidant activity was evaluated in vivo and in vitro using various assays. Results showed that FWEP exhibited strong antioxidant activities but no hemolytic activity was observed towards bovine erythrocytes.

The healing effect of Pistacia lentiscus fruit oil on laser burn.

Context: Since antiquity, Pistacia lentiscus L. (Anacardiaceae) fruit oil (PLFO) has been used as a remedy for primary health care such as burn treatment.

Objective: This study assesses the healing effect of PLFO on CO laser fractional burn in a rat model.

Oil from pumpkin (Cucurbita pepo L.) seeds: evaluation of its functional properties on wound healing in rats.

Background: Increasing natural drug demand for pharmaceutical uses has encouraged scientifics all over the world to explore medicinal plants recognized as efficient remedies. In this context, extracted oil from pumpkin seeds (Cucurbita pepo L.) is an interesting target, as it is composed with prominent pharmacological properties to possible wound healing treatments.

Phoenix dactylifera L. sap enhances wound healing in Wistar rats: Phytochemical and histological assessment.

The sap of the date palm "Lagmi" is a clear liquid, rich in sugars and minerals, with a pleasant flavour. Folk remedies based on the use of "Lagmi" for wound healing are still practiced. However, no studies investigated the relevance of "Lagmi" for wound healing.

The effect of natural extracts on laser burn wound healing.

Background: Despite the achievements in modern medicine, there is no effective natural treatment of second-degree burns till now. Therefore, the purpose of this study was to assess the wound-healing efficiency of three extracted oils, from the prickly pear, pumpkin and linseed on partial-thickness burns induced by fractional CO2 laser (an innovative up-to-date technique) in rats.

Materials And Methods: Thirty rats completing partial-thickness burns by fractional CO2 laser were randomly divided into five groups.

Antioxidant, antibacterial and in vivo dermal wound healing effects of Opuntia flower extracts.

Opuntia ficus-indica flowers are used for various medicinal purposes. The aims of the present investigation were to evaluate biological properties of O. ficus-indica flowers extracts and to investigate its antioxidant and antibacterial activities and its ability to enhance wound healing.

The evaluation of the healing proprieties of pumpkin and linseed oils on deep second-degree burns in rats.

Context: Medicinal plants have been recognized as useful remedies for primary health care. Accordingly, Cucurbita pepo L. (Cucurbitaceae) (pumpkin) and Linum usitatissimum (L.

Microstructure, rheological and wound healing properties of collagen-based gel from cuttlefish skin.

Collagen-based biomaterials are of the utmost importance for tissue engineering and regenerative medicine. The aims of the present investigation were to evaluate structural and rheological properties of collagen-based gel obtained from cuttlefish skin, and to investigate its ability to enhance wound healing. Scanning electron microscopy of resulted gel showed a dense fibrillar microstructure with high interconnection network with a smaller pore size.

Rhelogical, dermal wound healing and in vitro antioxidant properties of exopolysaccharide hydrogel from Pseudomonas stutzeri AS22.

The in vitro antioxidant activity and the in vivo wound healing performance of the exopolysaccharide EPS22, produced by Pseudomonas stutzeri AS22, were investigated. Antioxidant activity was evaluated by three different tests. The scavenging effect on DPPH radicals at a concentration of 1mg/ml was 80±1.

Healing efficiency of oligosaccharides generated from almond gum (Prunus amygdalus) on dermal wounds of adult rats.

Almond gum is a naturally occurring polymer produced by almond trees and shrubs. Its abundance, as well as its low cost production makes it a potential feedstock for use in food and pharmaceuticals. In this regard, almond gum oligosaccharides were enzymatically generated, purified and their monosaccharide composition assessed using gas chromatography-flame ionization detector.