Publications by authors named "San-lin You"
Article Synopsis
- The study examines the relationship between body mass index (BMI) and the risks of developing colorectal cancer (CRC) and dying from it in the Asian population, highlighting rising obesity rates and CRC incidence.
- The research pooled data from 17 cohort studies spanning from 1984 to 2002, with a median follow-up of 15.2 years and included nearly 620,000 participants for CRC incidence and over 650,000 for CRC-related mortality.
- Results indicate that higher BMI significantly increases the risk of incident CRC, with greater risks seen for those classified as obese, especially for colon cancer compared to rectal cancer, and a similar pattern was noted for CRC-related deaths.
Article Synopsis
- Thyroid cancer rates have risen significantly among Taiwanese females, with age-adjusted rates increasing from 7.37 to 20.53 per 100,000 people between 1995-1999 and 2015-2019, respectively.
- The study found younger females showed the highest increase in incidence rates, particularly in the 50-54 age group, with a notable trend linked to later birth cohorts.
- Researchers suggested that overdiagnosis might largely explain this trend, alongside a significant negative correlation between thyroid cancer incidence and fertility rates, highlighting a need for further investigation into these relationships.
Article Synopsis
- Body fatness is highlighted as a potential risk factor for biliary tract cancer (BTC), with established correlations between obesity and cholelithiasis (gallstones).
- A comprehensive analysis of data from over 905,000 participants across 21 studies in Asia found that higher body mass index (BMI) correlates with increased BTC mortality, especially in females.
- The study indicates that while obesity is linked to BTC mortality in women without gallstones, the relationship is less clear in men and when gallstones are present, suggesting complex interactions between BMI, gender, and gallstone presence.
Introduction: Although lung cancer prediction models are widely used to support risk-based screening, their performance outside Western populations remains uncertain. This study aims to evaluate the performance of 11 existing risk prediction models in multiple Asian populations and to refit prediction models for Asians.
Methods: In a pooled analysis of 186,458 Asian ever-smokers from 19 prospective cohorts, we assessed calibration (expected-to-observed ratio) and discrimination (area under the receiver operating characteristic curve [AUC]) for each model.
Article Synopsis
- Taiwan has one of the highest rates of upper tract urothelial cancer (UTUC) in the world, especially among women, but there has been no comprehensive long-term study on this issue.
- A nationwide analysis of UTUC incidence from 1985 to 2019 used data from the Taiwan Cancer Registry, breaking down the population into nine age groups to assess age-specific trends.
- The findings revealed a notable increase in renal pelvis cancer incidence, with women experiencing a higher rise than men, particularly in older age groups and among younger cohorts compared to older ones.
Article Synopsis
- In Taiwan, high rates of cigarette smoking, betel chewing, and alcohol consumption have led to significant cancer deaths, particularly in the oral cavity and throat.
- Analysis from 1980 to 2019 showed strong links between these cancers and lifestyle factors, with a notable period effect from 1990 to 2009 related to betel nut consumption and an ongoing effect from HPV on oropharyngeal cancers.
- Government initiatives to reduce smoking and betel quid usage since the 1990s have successfully stabilized cancer rates, suggesting continued policy impact may lead to further declines in head and neck cancer incidence.
Article Synopsis
- A study analyzed data from 2000-2013 in Taiwan to explore the link between HPV infection and colorectal cancer (CRC), comparing 358 HPV-infected patients to 1432 HPV-uninfected patients.
- The findings showed that the HPV-infected group had a notably higher incidence of CRC, with an adjusted hazard ratio indicating a 63% increased risk of CRC associated with HPV.
- This research provides evidence suggesting a connection between HPV and CRC, highlighting the need for further investigation into HPV's role in the development of colorectal cancer.
Article Synopsis
- * Researchers developed a comprehensive measure that combines these practices, finding significant positive associations with well-being across three diverse global cohorts (California, Hangzhou, and New Taipei), similar to or even stronger than the effects of physical activity.
- * The results suggest that incorporating multiple forms of contemplative practice into daily life could enhance well-being, providing valuable insights for public health recommendations.
Article Synopsis
- Intrahepatic cholangiocarcinoma (ICC) is a rare and aggressive cancer, prompting a study of its trends using Taiwan's national cancer registry database.
- The study found that the incidence of ICC significantly increased in Taiwan from 1993 to 2017, particularly among males, with higher rates in older age groups.
- The data indicates a concerning trend of ICC incidence rising among younger populations, suggesting a need for further investigation into risk factors.
Article Synopsis
- Chronic infections from hepatitis B and C viruses are leading causes of end-stage liver disease (ESLD), and controlling these infections is crucial for reducing ESLD rates.
- A study in Taiwan analyzed the impact of nationwide neonatal hepatitis B vaccinations and antiviral therapy programs on ESLD from 1979 to 2018, including data from nearly 43,604 individuals.
- Results showed significant reductions in chronic liver disease and hepatocellular carcinoma (HCC) mortality and incidence from 2004 to 2018, with an 82% decrease in CLD mortality among those born between 1982 and 2011.
Article Synopsis
- The study investigates how marital status affects overall and specific types of mortality rates in Asian populations by analyzing data from 16 studies in the Asia Cohort Consortium from 1963 to 2015.
- The findings indicate that unmarried individuals have a higher risk of death compared to married individuals, with significant hazards for total mortality and specific causes like cardiovascular diseases and cancer.
- Results show that being single, separated, divorced, or widowed is linked to an increased mortality risk, particularly among men and younger individuals under 65.
Article Synopsis
- A study investigated the link between body mass index (BMI) and oesophageal cancer (OC) mortality among over 842,000 Asians, highlighting notable differences compared to research on Europeans and North Americans.
- The analysis revealed a wide J-shaped association where both underweight individuals (BMI < 18.5) and those with extreme obesity (BMI ≥ 35) faced a significantly higher risk of OC mortality compared to the normal BMI range (23-25).
- Additionally, the research showed that smoking and alcohol consumption further heightened OC mortality risk for underweight participants, indicating a complex relationship between lifestyle factors, BMI, and cancer outcomes.
Article Synopsis
- Gastric cancer is a major cause of cancer deaths in Taiwan, ranking as the sixth leading cause of mortality for both genders, prompting the need for analysis of trends in incidence.
- A study using the Taiwan Cancer Registry found that gastric cancer rates have been decreasing annually for both males (-2.58%) and females (-2.14%), with higher incidence rates observed in older age groups.
- There is a notable correlation between the decrease in gastric cancer rates and the increasing use of antibiotic therapy for infection, suggesting that eradication efforts may be effective.
Background: Women with endometrial cancer (EC) have favorable prognoses, leaving them vulnerable to the development of second primary cancers (SPCs). We investigated the SPC risk and survival outcomes among EC patients treated with surgery alone in order to exclude the impact of adjuvant treatment on the results.
Methods: Data from the Taiwan Cancer Registry from 1995 to 2013 were analyzed.
Article Synopsis
- The study evaluated factors affecting outcomes in patients with platinum-sensitive recurrent epithelial ovarian carcinoma (EOC) using data from the National Health Insurance Research database in Taiwan from 2000 to 2013.
- Among 1038 patients, those treated with the platinum + paclitaxel (PT) regimen showed the best five-year overall survival (OS) rates compared to other treatment groups.
- The analysis indicated that the duration between platinum therapies significantly impacted survival outcomes, suggesting that PT is optimal for patients with a therapy-free interval of 6-12 months, while patients with longer intervals (>12 months) can benefit from either platinum-based or non-platinum chemotherapy options.
Article Synopsis
- The study aims to learn from the experiences of various countries that implemented a "find, test, trace, isolate, support" (FTTIS) approach during the early COVID-19 pandemic.
- A systematic review identified 118 studies, analyzing their objectives, methods, and outcomes to determine effective strategies for controlling disease spread when treatments or vaccines were unavailable.
- Key components of a successful FTTIS system include border controls, comprehensive testing, extended quarantines, digital tools for contact tracing, and support for those in isolation, all integrated through ongoing planning and coordination.
Article Synopsis
- Seven viruses, including EBV, HBV, HCV, KSHV, HIV-1, HTLV-1, and HPV, are classified as Group 1 human carcinogens by the IARC based on epidemiological and mechanistic studies.
- These viruses can directly or indirectly cause various cancers, with some individuals developing cancer while others do not, highlighting the complexity of cancer risk associated with these infections.
- Research has led to the development of risk calculators to predict the likelihood of specific cancers related to these viruses, and effective interventions like vaccination and antiviral therapies have shown a reduction in cancer incidence.
Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study.
Int J Environ Res Public Health
November 2020
Background: Results of studies regarding the potential link between acid suppressant use and dementia risk are inconsistent. This study aimed to evaluate the association of cumulative exposure to histamine 2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) with dementia risk in an Asian older cohort aged ≥65 years.
Methods: Patients initiating H2RA (the H2RA user cohort, = 21,449) or PPI (the PPI user cohort, = 6584) and those without prescription for H2RA (the H2RA non-user cohort, = 21,449) or PPI (the PPI non-user cohort, = 6584) between 1 January 2000 and 31 December 2005 without a prior history of dementia were identified from Taiwan's National Health Insurance Research Database (NHIRD).
Article Synopsis
- - The study aimed to evaluate how well measurements of specific apolipoproteins (apo A-I and apo B) can predict the risk of ischemic stroke, as previous research primarily focused on coronary heart disease.
- - Researchers analyzed data from over 4,200 participants, measuring apo levels in 2002 and then tracking them for an average of 4.61 years to see who experienced a stroke event.
- - Results showed that higher levels of apo B and the apo B/apo A-I ratio were linked to a greater risk of stroke, outperforming traditional lipid measurements like total cholesterol, suggesting that apo measurements are more useful for assessing stroke risk.
Serum Uric Acid Level as a Harbinger of Type 2 Diabetes: A Prospective Observation in Taiwan.
Int J Environ Res Public Health
March 2020
Article Synopsis
- The study investigates the relationship between serum uric acid (SUA) levels and the future risk of developing type 2 diabetes in a cohort of 4,130 participants who were diabetes-free at the start.
- It found a clear trend where higher SUA levels corresponded to increased incidence rates of type 2 diabetes, with statistically significant hazard ratios indicating this risk.
- The results suggest that elevated SUA is an independent risk factor for type 2 diabetes, highlighting its potential role in metabolic syndrome and future diabetes risk.
Article Synopsis
- The study aimed to understand health and well-being from the perspective of individuals, rather than focusing solely on disease prevention and treatment.
- Researchers interviewed 24 Taiwanese adults and identified eight key domains related to health and well-being, noting significant differences in how participants discussed each concept.
- The findings highlighted the importance of family and finances for well-being, while physical health and lifestyle behaviors were crucial for health, suggesting that these interconnected domains should inform public health programs.
The role of atopic dermatitis (AD) in the development of colorectal cancer (CRC) has been a matter of scientific debate with mixed results. We conducted a nationwide cohort study to assess the association between AD and risk of CRC. Drawing on Taiwan's National Health Insurance Research Database, 46,703 patients with AD (the AD cohort) and 186,812 sex, age, and index year-matched patients without AD (the non-AD cohort) were identified in the period between 2000 and 2008.
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- A retrospective cohort study investigated the link between obstructive sleep apnea (OSA) and colorectal cancer (CRC) in Taiwan's population, identifying 4180 patients with OSA and 16,720 matched controls without OSA.
- Results showed that individuals with OSA had a significantly higher risk of developing CRC (adjusted HR of 1.80) compared to those without OSA, with the risk increasing alongside the frequency of OSA medical visits.
- The study concluded that there is an association between OSA and elevated CRC risk, emphasizing the need for further large-scale prospective research to confirm these findings.
Article Synopsis
- A study was conducted to investigate the relationship between kidney transplantation (KT) and the risk of colorectal cancer (CRC) in a large population of hemodialysis patients in Taiwan.
- The research involved comparing 3,739 patients who underwent KT with 42,324 patients who did not undergo KT from 2000 to 2008, using data from the National Health Insurance Research Database.
- Results indicated that patients who received KT had a significantly higher cumulative incidence of CRC compared to those who did not, suggesting a need for ongoing cancer prevention strategies in KT recipients.
Article Synopsis
- Recent studies suggest that using citalopram with proton pump inhibitors like omeprazole may lower the effectiveness of the antidepressant and potentially increase the risk of sudden cardiac arrest (SCA).
- A study in Taiwan examined data from 2000 to 2013, comparing patients using only citalopram, only omeprazole, and both together, revealing higher SCA risks in those taking both drugs.
- Results showed that patients who took both citalopram and omeprazole had a significantly higher incidence of SCA, indicating a notable safety concern with this combination therapy.