Epigenetic regulation of angiogenesis in lung cancer.

Lung cancer is the leading cause of cancer-related deaths worldwide, in which angiogenesis is highly required for lung cancer cell growth and metastasis. Genetic regulation of this multistep process is being studied extensively, however, relatively less is known about the epigenetic regulation of angiogenesis in lung cancer. Several epigenetic alterations contribute to regulating angiogenesis, such as epimodifications of DNA, posttranslational modification of histones, and expression of noncoding RNAs.

Resveratrol Promotes Tumor Microvessel Growth via Endoglin and Extracellular Signal-Regulated Kinase Signaling Pathway and Enhances the Anticancer Efficacy of Gemcitabine against Lung Cancer.

The synergistic anticancer effect of gemcitabine (GEM) and resveratrol (RSVL) has been noted in certain cancer types. However, whether the same phenomenon would occur in lung cancer is unclear. Here, we uncovered the molecular mechanism by which RSVL enhances the anticancer effect of GEM against lung cancer cells both in vitro and in vivo.

Two new triterpenoids from Nauclea officinalis.

Two new triterpenoids and three 27-nor-triterpenoids were isolated from the stems (with bark) of Nauclea officinalis. Their structures were identified to be 2β,3β,19α,23-tetrahydroxy-urs-12-en-28-oic acid (1), 2β,3β,19α,23-tetrahydroxy-urs-12-en-28-O-[β-D-glucopyranosyl (1-2)-β-D-glucopyranosyl] ester (2), pyrocincholic acid 3β-O-α-L-rhamnopyranoside (3), pyrocincholic acid 3β-O-α-L-rhamnopyranosy 1-28-O-β-D-glucopyranosyl ester (4), pyrocincholic acid 3β-O-α-L-rhamnopyranosy1-28-O-β-D-glucopyranosyl-(1-6)-β-D-glucopyranosyl ester (5) by spectroscopic methods including 1D, 2D NMR and HR-MS analyses. The cytotoxic activity of 1-5 against lung cancer A-549 cells was also investigated.

Oldhamianoside II, a new triterpenoid saponin, prevents tumor growth via inducing cell apoptosis and inhibiting angiogenesis.

Oldhamianoside II is a new triterpenoid saponin that was isolated from the roots of Gypsophila oldhamiana. The present study aims to investigate the potential inhibitory activity of oldhamianoside II on tumor growth using an S180 tumor implantation mouse model. Oldhamianoside II at doses of 5.

A new triterpenoid saponin from Sanguisorba officinalis.

A new 19-oxo-18,19-seco-ursane-type triterpenoid saponin, named sanguisoside A (1), along with nine known triterpenoid saponins (2-10), was isolated from the roots of Sanguisorba officinalis. Their structures were determined on the basis of spectroscopic analysis and chemical method. Compounds 2 and 3 showed cytotoxic activity against SGC-7901, SMMC-7721, A549, and DU145 cell lines.

CIP-13F, a novel aminopeptidase N (APN/CD13) inhibitor, inhibits Lewis lung carcinoma growth and metastasis in mice.

Purpose: Aminopeptidase N (APN/CD13) is highly expressed on the surface of cancer cells and is thought to be involved in cancer growth and metastasis. The research of APN/CD13 inhibitors is considered as a strategy of cancer treatment. We aimed to evaluate the efficacy of CIP-13F, a novel APN/CD13 inhibitor, using a Lewis lung carcinoma (LLC) implantation mouse model.

[Pharmacokinetics study on yinhuang compound microenema in rabbits].

Objective: To determine the parameters of pharmacokinetics in rabbits, and to provide a scientific basis for clinical application of Yinhuang compound microenema.

Method: HPLC was used to determine the concentrations of chlorogenic acid and baicalin in the plasma samples of rabbits, then analyze these data by the pharmacokinetics program 3P97 to determine the parameters of pharmacokinetics and the compartmental model of both ingredients in Yinhuang compound microenema.

Result: Baicalin showed two compartment model in rabbits and the main parameters of pharmacokinetics were as follows: t(1/2)alpha of 0.