[Functional state of the frontal cortex and ventromedial hypothalamus during physical overexertion and experimental neurosis in the rabbit].

A change of excitability, pO2 and local cortical blood flow under a long-term maximum physical load and in conditions of experimental neurosis, was investigated in rabbits with electrodes implanted in the frontal cortex and ventromedial hypothalamus. It was found that functional activity of these structures under physical orverstrain rises as the blood flow and pO2 increase, and the excitability also increases. In experimental neurosis, a discoordination in functioning of the cortex and hypothalamus is observed.

[Effect of aminazine and seduxen on the intracentral relations of the formations of the hypothalamus-amygdaloid complex of the brain in experimental neurosis].

It has been shown in experiments on rabbits with electrodes implanted into the brain that at the initial period of experimental neurosis formation chlorpromazine and diazepam produce a depressant action on the reduction of intracentral relations between the structures under study. Chlorpromazine favours the formation of additional positive relations whereas diazepam activates the formations of negative relations. At the final stages of experimental neurosis the drug effects become less appreciable.