Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Triterpenes and Alkaloids from (Cham. & Schltdl.) Wawra.

A phytochemical study of leaves and twigs of resulted in 19 compounds, including five indole alkaloids, ,,-trimethyltryptamine, lyaloside, strictosamide, strictosidine, and 5α-carboxystrictosidine; two flavonolignans, cinchonain Ia and cinchonain Ib; an iridoid, roseoside; a sugar, lawsofructose; a coumarin, scopoletin; a diterpene, phytol; three triterpenes, pomolic acid, spinosic acid, and rotungenic acid; and five steroids, sitosterol, stigmasterol, campesterol, -sitosterol-3---d-glucoside, and -stigmasterol-3---d-glucoside. Some compounds were evaluated for their in vitro activity against and their ability to inhibit NO production by macrophages stimulated by lipopolysaccharide (LPS). The compounds pomolic acid, spinosic acid, strictosidine, and 5α-carboxystrictosidine displayed antimycobacterial activity with minimum inhibitory concentrations ranging from 7.

Two Novel Cycloartane-Type Triterpenes from C. DC. (Meliaceae).

Two new triterpenes cycloartane-type, named 24-methylencycloartan-12-oxo-3β,22α-diol and trichiliol, were isolated from the leaves of C. DC. together with three known triterpenes—24-methylencycloart-3β,22-diol, 22,25-dihydrocycloart-23()-en-3β-ol, and 22()-hydroxycycloart-24-en-3-ol.