Publications by authors named "Samya K Dyer"
The hormones estrogen and progesterone alter physiological functions, including the estrus cycle and relevant neurological and synaptic activity. Here, we determined the extent to which estrus cycle stage interacts with an inflammatory stimulus, lipopolysaccharide (LPS), to alter synaptic mitochondrial respiration in female rats. LPS elevated synaptic mitochondrial respiration of rats in estrus, but not diestrus.
View Article and Find Full Text PDFBackground: Repeated exposures to chronic stress can lead to long lasting negative behavioral and metabolic outcomes. Here, we aim to determine the impact of chronic stress and chronic low-level inflammation on behavior and synaptosomal metabolism.
Methods: Male (n = 31) and female (n = 32) C57Bl/6 mice underwent chronic repeated predation stress or daily handling for two rounds of 15 consecutive days of exposure during the adolescent and early adult timeframes.
Sex modifies the consequences of extended fructose consumption on liver health, motor function, and physiological damage in rats.
Am J Physiol Regul Integr Comp Physiol
December 2019
Article Synopsis
- The study investigates how high-fructose diets affect male and female rats differently, focusing on the long-term impacts of sex hormones and adolescent diet.
- Female rats showed significant weight gain and liver damage linked to nonalcoholic fatty liver disease (NAFLD), while male rats had increased blood glucose and moderate liver fat.
- Both sexes experienced motor deficits related to structural changes, but these were more severe in males, highlighting the need to consider sex differences in treating metabolic syndrome and related issues.