Publications by authors named "Samy Mahjoub"
Background: Decision of performing prostate biopsy in men with Prostate Imaging Reporting and Data System (PI-RADS) 3 findings in prostate magnetic resonance imaging (MRI) is challenging as they have a low but still relevant risk of harboring significant prostate cancer (sPC).
Objective: To identify clinical predictors of sPC in men with PI-RADS 3 lesions in prostate MRI and to analyze the hypothetical effect of incorporating prostate-specific antigen density (PSAD) into biopsy decision.
Design, Setting, And Participants: We analyzed a retrospective multinational cohort from ten academic centers comprising 1476 men who underwent a combined prostate biopsy (MRI targeted plus systematic biopsy) between February 2012 and April 2021 due to a PI-RADS 3 lesion in prostate MRI.
Article Synopsis
- MRI is crucial for detecting prostate lesions before a targeted biopsy, but it's still unclear how many biopsy cores from the lesion are necessary for an accurate diagnosis.
- A study analyzed data from 451 patients who underwent MRI-targeted biopsies, focusing on the number of cores needed and developing a prediction model for diagnosis accuracy.
- The findings revealed that 97% of relevant diagnoses were made after obtaining three biopsy cores, while a prediction model achieved an accuracy of 79%, suggesting that collecting at least three cores is essential for effective identification of significant lesions.
Available tests to detect clinically significant prostate cancer frequently lead to overdiagnosis and overtreatment. Our study assessed the feasibility of combining a urinary biomarker-based risk score (SelectMDx®) and multiparametric MRI outcomes in order to identify patients with prostate cancer on prostate biopsy with increased accuracy and reliability. Samples of 74 men with suspicion of prostate cancer and available multiparametric MRI were analysed in a prospective cross-sectional study design.
View Article and Find Full Text PDFIntroduction: Since the beginning of the pandemic in 2020, COVID-19 has changed the medical landscape. International recommendations for localized prostate cancer (PCa) include deferred treatment and adjusted therapeutic routines.
Materials And Methods: To longitudinally evaluate changes in PCa treatment strategies in urological and radiotherapy departments in Germany, a link to a survey was sent to 134 institutions covering two representative baseline weeks prior to the pandemic and 13 weeks from March 2020 to February 2021.
The definition of oligometastatic prostate cancer (OMPC) includes a heterogenous group of disease states, mostly defined by the number and site of metastases, which seems to be biologically different to widespread tumors. Evidence suggests a substantial survival benefit for this subgroup of limited metastatic burden which is currently seen as a potentially curable disease and therefore with an increasing interest in the scientific community. As there is still no consensus on the definition of OMPC, commonly used criteria are based on the CHAARTED and LATITUDE trials.
View Article and Find Full Text PDFIntroduction: Symptomatic lymphoceles (SLs) represent the most common complication after radical prostatectomy (RP) and pelvic lymph node dissection (PLND). To date, preoperative risk factors are missing.
Methods: Clinical and pathological data of 592 patients who underwent RP and PLND were evaluated.
The purpose of this study is to compare diagnostic performance of Prostate Imaging Reporting and Data System (PI-RADS) version (v) 2.1 and 2.0 for detection of Gleason Score (GS) ≥ 7 prostate cancer on MRI.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate if MRI size cut-offs can effectively identify clinically significant prostate cancer (csPCA), focusing on improving existing criteria in PI-RADS.
- MRIs from 293 patients were analyzed, with tumors measured from different zones and correlated with their Gleason grades; 309 lesions were examined.
- Results indicated that lesion size has a stronger association with clinically significant cancer in the peripheral zone (PZ) than in the transition zone (TZ), suggesting size cut-offs of 14 mm for PZ and 21 mm for TZ to better differentiate between cancer severities.
Objectives: To assess the discriminatory power of lexicon terms used in PI-RADS version 2 to describe MRI features of prostate lesions.
Methods: Four hundred fifty-four patients were included in this retrospective, institutional review board-approved study. Patients received multiparametric (mp) MRI and subsequent prostate biopsy including MRI/transrectal ultrasound fusion biopsy and 10-core systematic biopsy.
Purpose: To investigate the image quality, diagnostic accuracy, and dose reduction potential of a split-bolus protocol(SBP) compared with a multiphasic protocol(MPP) in the detection of recurrent or progressive pancreatic ductal adenocarcinoma(PDAC) or cholangiocarcinoma(CC) using contrast- enhanced computed tomography(CECT).
Materials And Methods: This prospective study included 56 patients who underwent CECT, 28 with our institutional standard MPP(100 ml contrast bolus) and 28 with a novel SBP(110 ml). Radiation exposure was determined in terms of total dose- length product(DLP) and computed tomography dose index(CTDI).