J Biomol Struct Dyn
December 2023
A new pyrimidine derivative Schiff base () [=2-((4-amino-6-chloropyrimidin-2-ylimino)methyl)-4-nitrophenol] has been synthesized using 2,6-diamino-4-chloropyrimidine and 5-nitrosalicylaldehyde. Transition metal complexes of Cu(II) and Zn(II) complexes [CuL(OAc)] (), [ZnL(OAc)] () are prepared with /metal(II) acetate with molar ratio of 1:1. The Schiff base () and the complexes and are evaluated by UV-Visible, 1H-NMR, FT-IR, EI-MS and ESR spectral techniques.
View Article and Find Full Text PDFJ Biomol Struct Dyn
December 2022
In this work, interactions of pyrimidine derivative Schiff base ligand (DMPMM) were studied and its stabilized powder nickel nanoparticles (DMPMM-NiNPs) were synthesized and various biological studies were evaluated. DNA binding studies of CT-DNA with prepared compounds in Tris-HCl/NaCl buffer were carried out by traditional UV-Visible and fluorescence spectroscopic methods, viscosity measurements and cyclic voltammetry. Results showed that the small scale of DMPMM had less activity to interact with biological systems and when it assembled on nickel nanoparticles surface the activity increased.
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