Publications by authors named "Samuele Gardin"
Background: Molnupiravir (MOL) and nirmatrelvir/ritonavir (NIR) decreased mortality and hospital admissions in high-risk patients with mild to moderate COVID-19. Nevertheless, there is a lack of data about the pharmacoeconomic impact of these antivirals in the Omicron era. We conducted a pharmacoeconomic analysis assessing the medical costs of the use of these antivirals compared to those occurred in people who refused the treatment.
View Article and Find Full Text PDFBackground: The introduction of rapid antigen tests revolutionized the approach to SARS-CoV-2 diagnosis, offering prompt and accurate results with high sensitivity and specificity. Although it is more cost- and time-saving than the gold standard, real-time polymerase chain reaction (RT-PCR), the efficacy in general population screening in both hospital- and community-based settings remains unknown. Moreover, rapid antigen testing is limited by qualitative results.
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- Injectable cabotegravir/rilpivirine (ICAB/RPV) has recently become available for HIV treatment, and this study aimed to evaluate its impact on sleep disturbances in patients who switched to this therapy.
- A total of 46 individuals participated, and they were assessed for sleep quality before and 12 weeks after starting ICAB/RPV using various sleep questionnaires; the demographic data and health records were also analyzed.
- Results showed no significant changes in sleep disturbance scores, although 37% reported feeling their sleep quality improved, indicating that switching to ICAB/RPV might have minimal negative effects on sleep despite previous concerns.
Article Synopsis
- Clinical trials showed that dolutegravir and lamivudine (DTG/3TC) are effective and safe for people living with HIV, but there’s a lack of long-term data for individuals aged 65 and older.
- A study involving 112 participants aged 65 and above found that most had multimorbidity, and after switching to DTG/3TC, there were no significant changes in health parameters over a 6-year follow-up.
- The study concluded that DTG/3TC is safe and effective for older adults with HIV, maintaining a high rate of undetectable viral loads and a low rate of treatment discontinuations due to side effects or virological failure.*
Recently, a benefit from administration of a 3-day course of early remdesivir (ER) in the outpatients' setting was reported. However, real-life data on its use is scarce. Therefore, we explored the ER clinical outcome in our outpatients' s cohort, compared to untreated controls.
View Article and Find Full Text PDFBackground: Molnupiravir (MOL) and nirmatrelvir/ritonavir (NIR) were recently approved for the early treatment of COVID-19, but real-life data on tolerability, safety, and adverse events (AEs) are still scarce.
Methods: We conducted a retrospective cohort study including all patients who were prescribed MOL and NIR at the Infectious Diseases Unit of Padua University Hospital, between January and May 2022. Demographic, clinical, and safety variables were recorded.
Article Synopsis
- SARS-CoV-2 can lead to severe illness and long-term health issues, yet there is limited information about the effects on people living with HIV (PLWH), particularly regarding post-acute COVID-19 syndrome (PACS).
- In a study of 123 unvaccinated adult PLWH treated for HIV who contracted SARS-CoV-2, various COVID-19 severities were noted, with polypharmacy being a significant risk factor for severe disease.
- Among the survivors, 26.7% experienced PACS, with fatigue, shortness of breath, and headaches being the most common symptoms; the severity of the initial COVID-19 episode was a strong predictor of PACS outcomes.
Article Synopsis
- Lung ultrasound (LUS) is an effective and convenient imaging tool for assessing COVID-19 pneumonia, allowing for bedside evaluation and ongoing monitoring of patients.
- A study of 96 hospitalized patients revealed that LUS patterns, such as B-lines and consolidations, are linked to disease severity and stage, particularly worsening during the intermediate period of illness (day 7 to 13 post-symptom onset).
- Results indicate that LUS can help differentiate between localized disease (consolidations) and generalized illness (B-lines), providing valuable insights into the patient's condition and related complications.
Background: Since the beginning of SARS-CoV-2 outbreak, a large number of infections have been reported among healthcare workers (HCWs). The aim of this study was to investigate the occurrence of SARS-CoV-2 infection among HCWs involved in the first management of infected patients and to describe the measures adopted to prevent the transmission in the hospital.
Methods: This prospective observational study was conducted between February 21 and April 16, 2020, in the Padua University Hospital (north-east Italy).
We report a facile production of an up-converted surface-emitting DFB laser, performed by exploiting the versatility of sol-gel chemistry, the intriguing properties of well designed graded CdSe-CdS-Cd(0.5)Zn(0.5)S-ZnS colloidal quantum dots, and the scalability of nanoimprinting.
View Article and Find Full Text PDFUV-curable SiO2-TiO2 films for the realization of diffractive optical elements.
J Nanosci Nanotechnol
January 2011
Hybrid SiO2-TiO2 films are prepared starting from tetraisopropoxy titanate and 3-glycidoxipropyltrimethoxysilane, using the sol-gel process. During the sol synthesis titania clusters grow, conferring to the samples a photocatalytic activity. In this paper we exploit this property for the fabrication of surface-relief gratings.
View Article and Find Full Text PDFIn this work, we report on the optical properties and amplified spontaneous emissions (ASE) of polystyrene opals engineered with planar structural defects containing a conjugated polymer emitter. Defects in opals give rise to allowed states inside the photonic stop band, which are probed by transmittance and reflectance spectroscopy. The emission spectrum of the polymer embedded in the defect layer is strongly modified and fingerprints of defect states located inside the stop band are recognized.
View Article and Find Full Text PDFWe present the design, theory and experimental implementation of a low modal volume microlaser based on a line-defect 2D-photonic crystal waveguide. The lateral confinement of low-group velocity modes is controlled by the post-processing of 1 to 3microm wide PMMA strips on top of two dimensional photonic crystal waveguides. Modal volume around 1.
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