Publications by authors named "Samuele Costelli"
Article Synopsis
- * Growth hormone deficiency (GHD) poses challenges due to varied diagnoses, daily treatment requirements, and lack of consistent biological markers, leading to a high potential for patient drop-out.
- * The review discusses GHD in transitioning patients, highlighting diagnostic difficulties, the importance of hormone replacement therapy, and the need for careful follow-up, especially in unique cases like cancer survivors.
Purpose: The discrepancy between the biomarkers of disease's activity in acromegalic patients (GH and IGF-1) is almost frequent representing a challenge for the development of comorbidities in the long term. The aim of this study was to evaluate the prevalence and severity of metabolic comorbidities (diabetes, hypertension, and dyslipidemia) in surgically treated acromegalic patients with disease control and discordant GH and/or IGF-1 levels compared with those with concordant values.
Patients And Methods: Retrospective monocentric observational study on acromegalic surgically treated patients with biochemical remission (group A) or mild discordant GH or IGF-1 levels (group B).