Antifungal Synergy: Mechanistic Insights into the R-1-R Peptide and Extract as Potent Therapeutics against spp. through Proteomics.

Previous reports have demonstrated that the peptide derived from LfcinB, R-1-R, exhibits anti- activity, which is enhanced when combined with an extract from the plant. However, the mechanism of action remains unexplored. In this research, a proteomic study was carried out, followed by a bioinformatic analysis and biological assays in both the SC5314 strain and a fluconazole-resistant isolate of after incubation with R-1-R.