Comparison of Corneal Epithelial and Stromal Thickness between Keratoconic and Normal Eyes in an Asian Population.

Purpose: To assess corneal epithelial and stromal thickness in keratoconic and normal eyes by spectral domain optical coherence tomography (SDOCT) in an Asian population.

Methods: Forty-three keratoconic and 24 normal eyes were studied and examined using SDOCT. Keratoconic eyes with corneal scarring were excluded.

Donor cornea preparation in partial big bubble deep anterior lamellar keratoplasty.

Background: The purpose of this paper is to describe a technique of donor cornea preparation to ensure good graft-host apposition in incomplete big bubble deep anterior lamellar keratoplasty.

Methods: Following a partial-thickness trephination, manual dissection and excision of corneal stroma was performed. Anwar's big-bubble technique involving a deep stromal air injection was then initiated.

Determination of torsade-causing potential of drug candidates using one-class classification and ensemble modelling approaches.

Adverse drug reactions (ADRs) are a main problem faced by drug companies and regulatory authorities. Not only do they contribute heavily to late-phase failure of drug development and withdrawal of drugs from the market, they also pose significant health risks to patients. Rare and severe ADRs are even harder to detect, and sufficient attention has not been paid to them.