Publications by authors named "Samuel Unzek"

Article Synopsis
  • A meta-analysis was conducted to evaluate the benefits of different exercise types for breast cancer patients, focusing on fitness and quality of life outcomes.
  • The analysis included 31 randomized controlled trials, revealing that exercise significantly improved cardiorespiratory fitness and physical function, while showing no significant improvements in muscle strength and fatigue.
  • Notably, exercise was found to enhance health-related quality of life for patients, indicating potential positive effects on their overall well-being.
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Purpose To examine the clinical effect of lead length and lead orientation in patients with cardiac implantable electronic devices (CIEDs) and lead fragments or abandoned leads undergoing 1.5-T MRI. Materials and Methods This Health Insurance Portability and Accountability Act-compliant retrospective study included patients with CIEDs and abandoned leads or lead fragments undergoing 1.

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Pregnancy and the post-partum period are known hypercoagulable states. Mid-cavitary variant Takotsubo cardiomyopathy (TCM) is uncommon and seen in only about 14% of all Takotsubo cases. Left ventricular thrombus (LVT) in the setting of mid-cavitary TCM is extremely rare, occurring in approximately 1% of cases.

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  • Landmark trials show SGLT2 inhibitors (SGLT2-Is) are beneficial for cardiovascular and renal diseases, but research on their effects on metabolic syndrome (MetS) is limited.
  • This study aimed to analyze how SGLT2-Is affect the components of MetS by reviewing various trials and conducting a meta-analysis.
  • Results indicated that SGLT2-Is significantly reduced fasting plasma glucose, systolic blood pressure, and waist circumference, with no notable effect on HDL cholesterol, suggesting their potential in managing MetS.
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In patients with a contraindication to oral anticoagulation, the left atrial appendage occlusion devices are an approved alternative. Device-related thrombus is a recognized complication, but underlying mechanisms are incompletely understood. In this case series, the authors describe potentially the same mechanism of thrombosis with intraoperative images of incomplete endothelialization.

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We report a case of a 57-year-old woman with a history of multiple myeloma (MM) and light chain (AL) amyloidosis who presented due to worsening dyspnea on exertion. Her MM has been refractory to multiple chemotherapy regimens and two autologous bone marrow transplantation. Diagnostic evaluations including serum kappa and lambda chains, echocardiogram, pyrophosphate cardiac scan, and cardiac magnetic resonance were indicative of a progression to AL cardiomyopathy.

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  • Doctors looked at studies to see if new blood thinners called DOACs are safe and work well for cancer patients who have blood clots.
  • They found that DOACs reduce the chances of blood clots coming back compared to other treatments, like LMWH and VKAs.
  • While DOACs may have a bit of a bleeding risk, they are considered safer and better for most patients who have cancer-related blood clots.
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  • Individualized guided selection of antiplatelet therapy, which uses genetic and platelet function testing, has the potential to improve outcomes for patients undergoing percutaneous coronary intervention (PCI) compared to standard therapy.
  • A systematic review pooled data from 11 clinical trials involving 18,465 patients and found that guided therapy significantly reduced major adverse cardiovascular events (MACE), heart attacks (MI), stent thrombosis (ST), strokes, and minor bleeding.
  • The results suggest that implementing genetic and platelet function testing can lead to better antiplatelet therapy choices for patients, ultimately enhancing their overall health outcomes.
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  • Pericardial fluid, about 10-50 ml in volume, is crucial for maintaining heart and pericardial stability, and its abnormal buildup is known as pericardial effusion.
  • Various imaging tools like chest X-rays, echocardiograms, and MRI are used to diagnose pericardial effusion.
  • Once diagnosed, treatment options range from minimally invasive procedures like pericardiocentesis to more invasive ones like sclerosing therapies, with recent studies assessing their effectiveness in clinical settings.
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  • The text discusses a rare case of an elderly patient with multiple giant coronary artery aneurysms caused by Kawasaki disease, which is unusual for this age group.
  • It highlights that these aneurysms predominantly affect the left coronary system, contrasting with the more common right coronary aneurysms.
  • The elderly patient experienced ischemic symptoms, but after undergoing coronary artery bypass grafting, there was significant relief from these symptoms.
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There are limited data on the head-to-head comparison of Tc-pyrophosphate (Tc-PYP) and echocardiographic strain imaging in the assessment of transthyretin (TTR) cardiac amyloidosis. At Mayo Clinic Arizona, patients who had undergone both a Tc-PYP scan and a transthoracic echocardiogram within a 90-d period were retrospectively identified for chart review and strain imaging analysis. Patients were divided into 2 groups according to their Tc-PYP results (PYP-positive [PYP+] or PYP-negative [PYP]) for the comparison.

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  • Heart failure prevalence is rising, affecting about 23 million people worldwide, prompting interest in Sodium-Glucose Cotransporter-2 inhibitors (SGLT2i) for treatment in both diabetic and non-diabetic patients.
  • A review of 864 studies found three randomized controlled trials (RCTs) with nearly 10,000 heart failure patients, demonstrating a significant reduction in adverse outcomes when using SGLT2i.
  • The findings support the safe combination of SGLT2i with ARNI therapy to enhance treatment outcomes for specific heart failure patients.
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Pericardial disease is a recognized manifestation of cardiovascular disease in the end-stage renal disease (ESRD) population, and can manifest as pericardial effusion, though the prognosis of pericardial disease in ESRD patients is unclear. In the modern era of renal replacement therapy, little is known about the prevalence and the implications of pericardial effusion in ESRD patients, its echocardiographic characteristics, and risk factors. We conducted a retrospective chart review on subjects > than 18 years of age with known ESRD who were undergoing outpatient evaluation for renal transplantation at Mayo Clinic Arizona between January 2001 and December 2015 and had baseline echocardiogram completed within 3 months of their initial evaluation.

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Nuclear stress testing is being increasingly justified in the cardiovascular risk stratification of patients. Radiation is an important consideration, and attempts to minimize exposure should be implemented. Efficiency and cost effectiveness are cornerstones in the delivery of quality patient care and should also be considered when implementing change.

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Background: Significant heterogeneity exists in practice patterns and algorithms used for cardiac screening before kidney transplant. Cardiorespiratory fitness, as measured by peak oxygen uptake (VO), is an established validated predictor of future cardiovascular morbidity and mortality in both healthy and diseased populations. The literature supports its use among asymptomatic patients in abrogating the need for further cardiac testing.

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Background: The cardiopulmonary benefits of pectus excavatum repair have been debated. Echocardiographic speckle-tracking strain and strain rate have been used to evaluate and detect subclinical myocardial dysfunction in patients receiving cardiotoxic chemotherapy, and patients with valvular heart disease. This technology was applied to evaluate the effects of pectus excavatum surgery on left ventricular (LV) and right ventricular (RV) function.

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We aimed to determine the effect of short-term right ventricle pacing (RV) on left ventricle (LV) mechanics using speckle tracking analysis. Conventional echocardiography and two-dimensional strain imaging was studied in 38 patients, mean age 81.6 ± 7.

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Whilst the prevalence of aortic valve stenosis (AS) increases with age (1), surgery restores age-corrected survival to near normal. In parallel with senescence, comorbidities are present, one such example being chronic obstructive pulmonary disease (COPD), which causes significant disability and is the third leading cause of death in the United Sates (2). The presence of COPD is associated with increased perioperative complications, and serve as a reason to deny a patient surgical intervention because of the increased surgical risk (3).

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Objectives: We sought the impact of recent recommendations on observer concordance on interpretation of diastolic stage and assessment of filling pressure.

Background: Worsening stages of diastolic dysfunction are associated with worsening outcome. However, the echocardiographic classification of diastolic function is complex, and parameters may be discordant.

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