Publications by authors named "Samuel Sung"
Article Synopsis
- The study examined how different types of immune cells, especially macrophages, respond in cases of muscle damage leading to either regeneration or fibrosis in mice.
- It found that macrophage dysfunction occurs early in the process and is linked to higher levels of inflammation and other immune cells in the affected areas.
- Interestingly, while neutrophils were more common in cases of fibrosis, their removal didn't significantly impact the behavior of macrophages or overall muscle healing, indicating that a broader understanding of immune cell interactions is needed for better muscle repair strategies.
Biomaterial-assisted macrophage cell therapy for regenerative medicine.
Adv Drug Deliv Rev
August 2023
Although most tissue types are capable of some form of self-repair and regeneration, injuries that are larger than a critical threshold or those occurring in the setting of certain diseases can lead to impaired healing and ultimately loss of structure and function. The immune system plays an important role in tissue repair and must be considered in the design of therapies in regenerative medicine. In particular, macrophage cell therapy has emerged as a promising strategy that leverages the reparative roles of these cells.
View Article and Find Full Text PDFLong-acting antiretroviral implants could help protect high-risk individuals from HIV infection. We describe the design and testing of a long-acting reservoir subcutaneous implant capable of releasing cabotegravir for several months. We compressed cabotegravir and excipients into cylindrical pellets and heat-sealed them in tubing composed of hydrophilic poly(ether-urethane) -.
View Article and Find Full Text PDFPurpose: Sexual transmission of HIV has been clinically proven to be preventable with a once-daily oral tablet; however, missed doses dramatically increase the risk of HIV infection. Long-acting subcutaneous implants do not allow the user to miss a dose. A desirable long-acting drug-eluting implant can deliver a constant amount of drug, adjust the delivered dose, and be readily manufactured.
View Article and Find Full Text PDFArticle Synopsis
- This study evaluates a subcutaneous implant that delivers tenofovir alafenamide (TAF) for HIV prevention, showing effective drug delivery for over 90 days.
- It involved testing in New Zealand White rabbits and rhesus macaques, revealing that higher doses led to significant local inflammation and tissue damage around the implants.
- A redesigned implant with a lower release rate achieved effective drug levels but still caused unacceptable inflammation in primates, highlighting challenges in balancing drug efficacy and safety.
Purpose: Design of intravaginal rings (IVRs) for delivery of antiretrovirals is often guided by in vitro release under sink conditions, based on the assumption that in vivo release will follow a similar release profile.
Methods: We conducted a dose-ranging study in the female reproductive tract of pigtail macaques using matrix IVRs containing IQP-0528, a poorly soluble but highly potent antiretroviral drug with an IC of 146 ng/mL. These IVRs consisted of drug-loaded segments, 15.
Background: Reported vaginal and seminal fluid simulants have complex compositions with multiple preparatory steps that contribute to physical instability. We report the design and characterization of stable and simplified buffers that mimic the salient physical/chemical properties of the physiological fluids.
Study Design/methods: Human cervicovaginal and seminal fluid samples were collected and buffering capacity was determined.