Publications by authors named "Samuel Simon-Sanchez"
The endocannabinoid (eCB) system, via the cannabinoid CB receptor, regulates neurodevelopment by controlling neural progenitor proliferation and neurogenesis. CB receptor signalling drives corticofugal deep layer projection neuron development through the regulation of BCL11B and SATB2 transcription factors. Here, we investigated the role of eCB signalling in mouse pluripotent embryonic stem cell-derived neuronal differentiation.
View Article and Find Full Text PDFArticle Synopsis
- Prenatal exposure to THC disrupts the development of key brain cells, impacting adult behavior and neuroplasticity, particularly in male offspring.
- Adult mice exposed to THC in the womb exhibit problems with spatial memory and altered brain activity patterns, highlighting a specific vulnerability in males.
- The study indicates that THC affects CCK-containing interneurons differently in male versus female mice, suggesting a unique mechanism behind the observed cognitive impairments linked to prenatal cannabis use.