Publications by authors named "Samuel R Santos Junior"

Article Synopsis
  • A study highlights the development of two semisynthetic vaccine candidates targeting a fungus that poses serious risks to immunocompromised patients, focusing on its key polysaccharide, glucuronoxylomannan (GXM).
  • The vaccines, containing a synthetic decasaccharide antigen (M2 motif), were conjugated to two proteins and tested in mice, showing specific immune responses and some cross-reactivity to other GXM variants.
  • While one glycoconjugate showed potential for increased survival in mice, further optimizations are needed before it can be considered for a multivalent GXM vaccine.
View Article and Find Full Text PDF

The accumulation of chitin waste from the seafood industry is a serious environmental problem. However, this residue can be degraded by chitinases and its subproducts, such as chitosan, economically exploited. In this study, a chitinase producer bacteria, identified as Paenibacillus illinoisensis, was isolated from the Brazilian coastal city of Terra de Areia - Rio Grande Do Sul (RS) and was immobilized within alginate beads to evaluate its chitinase production.

View Article and Find Full Text PDF

The whole-cell immobilization on chitosan matrix was evaluated. Bacillus sp., as producer of CGTase, was grown in solid-state and batch cultivation using three types of starches (cassava, potato and cornstarch).

View Article and Find Full Text PDF