Publications by authors named "Samuel R Santos Junior"
Article Synopsis
- A study highlights the development of two semisynthetic vaccine candidates targeting a fungus that poses serious risks to immunocompromised patients, focusing on its key polysaccharide, glucuronoxylomannan (GXM).
- The vaccines, containing a synthetic decasaccharide antigen (M2 motif), were conjugated to two proteins and tested in mice, showing specific immune responses and some cross-reactivity to other GXM variants.
- While one glycoconjugate showed potential for increased survival in mice, further optimizations are needed before it can be considered for a multivalent GXM vaccine.
Increased production of chitinase by a Paenibacillus illinoisensis isolated from Brazilian coastal soil when immobilized in alginate beads.
Francenya Kelley Lopes da Silva Artur Ribeiro de Sa Alexandre Ariadine Amorim Casas Maycon Carvalho Ribeiro Keili Maria Cardoso de Souza Samuel Rodrigues Dos Santos Junior
Folia Microbiol (Praha)
December 2022
The accumulation of chitin waste from the seafood industry is a serious environmental problem. However, this residue can be degraded by chitinases and its subproducts, such as chitosan, economically exploited. In this study, a chitinase producer bacteria, identified as Paenibacillus illinoisensis, was isolated from the Brazilian coastal city of Terra de Areia - Rio Grande Do Sul (RS) and was immobilized within alginate beads to evaluate its chitinase production.
View Article and Find Full Text PDFThe whole-cell immobilization on chitosan matrix was evaluated. Bacillus sp., as producer of CGTase, was grown in solid-state and batch cultivation using three types of starches (cassava, potato and cornstarch).
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